Publication

Abstract : Micro RNA (miRNA) is a non-coding RNA (ncRNA) which was discovered in 1993. It consists of 19-25 nucleotides and it regulates the expression of around 30% of protein coding mRNAs in humans. Recent studies on miRNAs suggest the fact that it has a vital role in the post-transcriptional gene regulation of skin development and in future it can also be used for treating skin diseases. Certain number of novel miRNAs has been identified in skin and various studies were done on the functional roles of miRNAs in psoriasis. In this manuscript, we review the profiling and characterization of miRNAs in the psoriatic skin of humans and discuss its implication in various biological activities and we also share our views on the application of Bioinformatics in predicting novel miRNAs along with the nanotechnology based miRNA delivery to understand the disease pathology of Psoriasis which is followed by treatment. There is a broader scope for addressing the challenges in miRNA based drug delivery in future.