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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Nanomedicine: Nanotechnology, Biology, and Medicine
Source : Nanomedicine: Nanotechnology, Biology, and Medicine (2013)
Campus : Kochi
School : Center for Nanosciences
Center : Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2013
Abstract : pA multifunctional core-shell nanomedicine capable of inhibiting the migratory capacity of metastatic cancer cells followed by imparting cytotoxic stress by photodynamic action is reported. Based on in silico design, we have developed a core-shell nanomedicine comprising of nbsp; 80 nm size poly(lactic-co-glycolic acid) (PLGA) nano-core encapsulating photosensitizer, m-tetra(hydroxyphenyl)chlorin (mTHPC), and nbsp; 20 nm size albumin nano-shell encapsulating tyrosine kinase inhibitor, Dasatinib, which impair cancer migration. This system was prepared by a sequential process involving electrospray of polymer core and coacervation of protein shell. Cell studies using metastatic breast cancer cells demonstrated disruption of Src kinase involved in the cancer migration by albumin-dasatinib nano-shell and generation of photoactivated oxidative stress by mTHPC-PLGA nano-core. This unique combinatorial photo-chemo nanotherapy resulted synergistic cytotoxicity in nbsp; 99% of the motility-impaired metastatic cells. This approach of blocking cancer migration followed by photodynamic killing using rationally designed nanomedicine is a promising new strategy against cancer metastasis. © 2013./p
Cite this Research Publication : G. L. Malarvizhi, Chandran, P., Retnakumari, A. P., Ramachandran, R., Gupta, N., Nair, S., and Koyakutty, M., “A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing”, Nanomedicine: Nanotechnology, Biology, and Medicine, 2013.