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A Molecular Docking and Pharmacokinetic Prediction of Thiazolidine-2, 4-dione Derivatives: Toward Novel Therapeutic Targets for Type-2 Diabetes Mellitus

Publication Type : Journal Article

Publisher : IJCB

Source : International. Journal for Computational Biology (IJCB) 2019, 8 (1).

Url : https://www.researchgate.net/profile/Sonal-Gupta-18/publication/340645152_A_Molecular_Docking_and_Pharmacokinetic_Prediction_of_Thiazolidine-2_4-dione_Derivatives_Toward_Novel_Therapeutic_Targets_for_Type-2_Diabetes_Mellitus/links/5e969c0a4585150839de71ff/A-Molecular-Docking-and-Pharmacokinetic-Prediction-of-Thiazolidine-2-4-dione-Derivatives-Toward-Novel-Therapeutic-Targets-for-Type-2-Diabetes-Mellitus.pdf

Campus : Amritapuri

School : School of Biotechnology

Department : Chemistry

Year : 2019

Abstract : Type 2 diabetes mellitus (T2DM) is a leading endocrine disorder that affects millions of people worldwide. It is characterized by hyperglycemia and high insulin resistance. The commonly prescribed oral therapeutic for insulin resistance in T2DM is Thiazolidine-2, 4-diones (TZDs). TZDs are a class of oral hypoglycemic agents that act on Peroxisome proliferator activating receptor-γ (PPAR-γ) receptors and are mainly expressed in the adipose tissues. In this work, we derive novel classes of TZDs and predict the nature of Keyword: structural affinity using docking studies against the PPAR-γ

Cite this Research Publication : Tiwari, P.; Suravajhala, R.; Gupta, S.; Chaturvedi, P.; Mathur, S. K.; Solanki, P. S.; Malik,B. A Molecular Docking and Pharmacokinetic Prediction of Thiazolidine-2, 4-Dione Derivatives: Toward Novel Therapeutic Targets for Type-2 Diabetes Mellitus. International. Journal for Computational Biology (IJCB) 2019, 8 (1).

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