Publication Type : Journal Article
Publisher : Chem Commun (Camb)
Source : Chem Commun (Camb). 2017 Aug 11; 53(62):8802-8805. doi: 10.1039/c7cc05339h. ISSN: 1359-7345
Url : http://dx.doi.org/10.1039/C7CC05339H
Campus : Amritapuri, Coimbatore
School : School of Biotechnology, School of Engineering
Center : Center for Industrial Research and Innovation (ACIRI)
Department : biotechnology
Year : 2017
Abstract : We report the application of a chemodosimeter {'}turn on{'} fluorescent probe for detecting endogenous H2S formation in cancer cells. Mito-HS showed a bathochromic shift in the UV-vis-absorption spectrum from 355 nm to 395 nm in the presence of H2S. Furthermore{,} it showed an [similar]43-fold fluorescence enhancement at [small lambda]em = 450 nm in the presence of H2S (200 [small mu ]M). The cancer cell-specific fluorescence imaging reveals that Mito-HS has the ability to distinguish cancer cells from normal cells based on the level of endogenous H2S formation. In due course{,} Mito-HS would be a powerful cancer biomarker based on its ability to estimate endogenous H2S formation in living cells.
Cite this Research Publication :
N. Velusamy, Anupama Binoy, Bobba, K. Naidu, Divya Nedungadi, Dr. Nandita Mishra, and Bhuniya, S., “A bioorthogonal fluorescent probe for mitochondrial hydrogen sulfide: new strategy for cancer cell labeling”, Chem Commun (Camb)., vol. 53, no. 62, pp. 8802-8805, 2017.