Publication

Abstract : In the past two decades, significant research has been conducted to make artificial bone with the use of metals, ceramics, and polymers. Composite of biopolymer (chitosan) and bioceramic (nanohydroxyapatite—nHA) is a promising approach and these are widely studied biomaterials for bone-graft substitution. In the present review, we discussed the preparative method, mechanical properties, cell proliferation, alkaline phosphatase activity, mineralization effect and innbsp;vivo study of chitosan–nHA composite for bone-tissue regeneration. Chitosan–nHA composites containing third-component systems (synthetic polymers, growth factors, and stem cells) were discussed for better bone formation. Hence, the composite of chitosan–nHA will be a promising biomaterial for bone-tissue engineering .