Back close

Proteasome inhibitors from natural products

School: School of Biotechnology

Project Incharge:Dr. Nandita Mishra
Proteasome inhibitors from natural products

The ubiquitin-proteasome system (UPS) plays an essential role in many cellular processes, including cell cycle progression, proliferation, apoptosis and angiogenesis. Proteasome inhibitors like Bortezomib (Velcade, PS-341), has been successfully used as anticancer drug. Several natural compounds, including the green tea polyphenols, microbial metabolite lactacystin and many triterpenes have been shown to be potent proteasome inhibitors. One of our ongoing project is to screen novel proteasomal inhibitors from natural products that induce cell death in cancer cells.

Related Projects

Furfuryl Derivatives of Meldrum’s Acid: Synthesis, Characterisation and Biological Studies
Furfuryl Derivatives of Meldrum’s Acid: Synthesis, Characterisation and Biological Studies
Regulation of Inflammation by Natural Product extracts: Role in osteoclastogenesis
Regulation of Inflammation by Natural Product extracts: Role in osteoclastogenesis
Paraptosis: a non-apoptotic cell death pathway to target cancer
Paraptosis: a non-apoptotic cell death pathway to target cancer
Antimicrobial Activity of Different Plant Parts and Their Combinatorial Effects with Antibiotics
Antimicrobial Activity of Different Plant Parts and Their Combinatorial Effects with Antibiotics
Seabuckthorn – A Repository of Bioactive Phytochemicals
Seabuckthorn – A Repository of Bioactive Phytochemicals
Admissions Apply Now