Back close

Proteasome inhibitors from natural products

School: School of Biotechnology

Project Incharge:Dr. Nandita Mishra
Proteasome inhibitors from natural products

The ubiquitin-proteasome system (UPS) plays an essential role in many cellular processes, including cell cycle progression, proliferation, apoptosis and angiogenesis. Proteasome inhibitors like Bortezomib (Velcade, PS-341), has been successfully used as anticancer drug. Several natural compounds, including the green tea polyphenols, microbial metabolite lactacystin and many triterpenes have been shown to be potent proteasome inhibitors. One of our ongoing project is to screen novel proteasomal inhibitors from natural products that induce cell death in cancer cells.

Related Projects

Theoretical and Empirical Investigations on the Interaction of Asymmetric Migration and Intrinsic Growth Rate on the Dynamics of Laboratory Metapopulations of Drosophila Melanogaster
Theoretical and Empirical Investigations on the Interaction of Asymmetric Migration and Intrinsic Growth Rate on the Dynamics of Laboratory Metapopulations of Drosophila Melanogaster
Production, Optimization and Characterization of Chitinase Enzyme Produced By Aspergillus Sp
Production, Optimization and Characterization of Chitinase Enzyme Produced By Aspergillus Sp
MIMIC – A Unique approach to wound healing assays
MIMIC – A Unique approach to wound healing assays
Production, Purification and Application of Naringinase from soil isolates of Aspergillus Sp
Production, Purification and Application of Naringinase from soil isolates of Aspergillus Sp
Development of chromatographic separation and detection techniques for natural products, as plant extracts, peptides, proteins and carbohydrates
Development of chromatographic separation and detection techniques for natural products, as plant extracts, peptides, proteins and carbohydrates
Admissions Apply Now