Back close

Paraptosis: a non-apoptotic cell death pathway to target cancer

School: School of Biotechnology

Paraptosis: a non-apoptotic cell death pathway to target cancer

Many cancer cells develop resistance to the apoptotic signals and flourish in the system. We are trying to target these defiant cells by inducing an alternative cell death pathway through natural products. One of the non-apoptotic mode of programmed cell death known as “paraptosis” or cytoplasmic vacuolation mediated cell death is one of our areas of interest.

We screen a large number of natural products and synthetic derivatives for anti-cancer activity in collaboration with Professor Asoke Banerji of School of Biotechnology and try to understand their mode of action with respect to cell death. Along with screening for anticancer compounds, we filter natural products that cause parasitic death. We are using C. elegans as an in vivo model system to study anti-parasitic and anti-cancer death mechanism in collaboration with Dr. Sanjay Pal.

Related Projects

DNA ORIGAMI – Folding of the Vector (pCDH–CMV–MCS–EF1–puro) into a Predefined Shape Using 18, 20mer Staples
DNA ORIGAMI – Folding of the Vector (pCDH–CMV–MCS–EF1–puro) into a Predefined Shape Using 18, 20mer Staples
Matrix Binding microbes and bacteriophages to counter infection
Matrix Binding microbes and bacteriophages to counter infection
Screening for Quorum Sensing Inhibitors from Edible Leaves and Oils
Screening for Quorum Sensing Inhibitors from Edible Leaves and Oils
Synthesis of Intermediate Analogues for Biologically Active Molecules
Synthesis of Intermediate Analogues for Biologically Active Molecules
Use of viral agents, microbial fuel cell and effec tive recycling strategy to improve the economics of human waste disposal
Use of viral agents, microbial fuel cell and effec tive recycling strategy to improve the economics of human waste disposal
Admissions Apply Now