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Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which originate from the intrinsic nature of the enzymes. This project aims at developing a commercially viable non-enzymatic glucose sensor strip and a glucometer. Electrode surface modified with transition metal and metal oxide nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. These sensors are found to have excellent performance in relation to mass transport, catalysis, good biocompatibility and control over the electrode microenvironment. Therefore, their use is an important strategy in the construction of non-enzymatic glucose sensors. Keeping this in mind, a metal oxide based nonenzymatic glucose sensor is being explored for mass production and commercial viability.