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Dr Hemalatha Sasidharakurup is a Research Associate at the Amrita Mind Brain Center. She has a PhD in Computational Neuroscience from the Amrita School of Biotechnology at Amrita Vishwa Vidyapeetham. Her research focuses on Computational Modelling of Neurological Conditions, integrating principles from systems biology, mathematics, and computational modelling. Her work extends to the detailed analysis of pathway modelling for Alzheimer’s and Parkinson’s diseases, looking into the complexities and commonness of these neurodegenerative conditions. Her research explores the different roles of abnormal protein aggregation, genetic mutations, gut-microbiome connection, oxidative stress, inflammation, and insulin resistance in neurodegeneration. This extends to building disease models for researchers and experimentalists, and also the development of digital patient twins for clinicians and healthcare systems, aiming to facilitate early diagnosis and enhance treatment strategies. 

Educational Background

  • Ph.D. in Computational Neuroscience, School of Biotechnology, Amrita Vishwa Vidyapeetham
  • M.Sc. in Bioinformatics, School of Biotechnology, Amrita Vishwa Vidyapeetham
  • B.Sc. in Biotechnology, School of Biotechnology, Amrita Vishwa Vidyapeetham 

Publications 

Journal Articles 

  • [2021] Sasidharakurup, H., Kumar, G., Nair, B., & Diwakar, S. (2021). Mathematical Modeling of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Network with Cytokine Storm, Oxidative Stress, Thrombosis, Insulin Resistance, and Nitric Oxide Pathways. Omics: a journal of integrative biology. 
  • [2020] Sasidharakurup, H., Diwakar, S. Computational modelling of TNFα related pathways regulated by neuroinflammation, oxidative stress and insulin resistance in neurodegeneration. Appl Netw Sci 5, 72 (2020). 
  • [2017] Hemalatha Sasidharakurup, Nidheesh Melethadathil, Bipin Nair, Shyam Diwakar: A Systems Model of Biological Interactions in Parkinson’s disease Using Biochemical Systems Theory, OMICS: A Journal of Integrative Biology. 
  • [2017] Rajendran A. G, Nutakki C, Sasidharakurup H, Bodda S, Nair B, Diwakar S (2017) Cerebellum in Neurological Disorders: A Review on the Role of Inter-Connected Neural Circuits. J Neurol Stroke 6(2): 00196.  
  • [2016] Diwakar S, Kumar D, Radhamani R, Sasidharakurup H, Nizar N, Achuthan K, Nedungadi P, Raman R, Nair B. Complementing Education via Virtual Labs: Implementation and Deployment of Remote Laboratories and Usage Analysis in South Indian Villages, International Journal of Online Engineering (iJOE), Vol 12, No 3, pp 8-15, 2016. 
  • [2016] Pramod Darvin, Youn Hee Joung, Dong Young Kang, Nipin Sp, Hyo Joo Byun, Tae Sook Hwang, Hema Sasidharakurup, Chi Ho Lee c, Kwang Hyun Cho, Kyung Do Park, Hak Kyo Lee,Young Mok Yang. Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells. Journal of Cellular and Molecular Medicine (2016). 
  • [2015] H. Sasidharakurup, R. Radhamani, D. Kumar, and N. Nizar, “Using Virtual Laboratories as Interactive Textbooks: Studies on Blended Learning in Biotechnology Classrooms,” EAI Endorsed Trans. e-Learning, pp. 1–13, 2015. 

 Book Chapter 

  • [2022] H. Sasidharakurup, D. Pisharody, H. Bose, D. Rajan, and S. Diwakar, “Mathematical Modelling of Glucocerebrosidase Signalling Networks Linked to Neurodegeneration.,” in Research Advances in Network Technologies, 1st ed., CRC Press, Taylor & Francis Group, 2023. 
  • [2014] Shyam Diwakar, Rakhi Radhamani, Gopika Sujatha, Hemalatha Sasidharakurup, Akhila Shekhar, Krishnashree Achuthan, Prema Nedungadi, Raghu Raman and Bipin Nair (2014).  Usage and Diffusion of Biotechnology Virtual Labs for Enhancing University Education in India’s Urban and Rural Areas, E-learning as a Socio-Cultural System: A Multidimensional Analysis, Zuzevičiūtė  V, Butrimė E,  Vitkutė-Adžgauskienė  D, FominVV  and  Kikis-Papadakis K(Ed.) 

Conferences 

  • [2023] Hemalatha Sasidharakurup, Kasi Viswanadh, Divya M Sasidharan, Anu Sasidharan, Arushi Tiwari, Devi Krishna, Giovanni Naldi, Egidio D’Angelo and Shyam Diwakar, Computational Modelling of Glucocerebrosidase Signalling Pathways in Parkinson’s Disease, Fourth International Conference on Advanced Computational and Communication Paradigms, Sikkim, Manipal Institute of Technology, Sikkim, India [2023] 
  • [2021] Hemalatha Sasidharakurup, Dheeraj Pisharody, Haritha Bose, Dijith Rajan and Shyam Diwakar, Mathematical Modelling of Glucocerebrosidase Signalling Networks Linked to Neurodegeneration, International Conference on Advanced Network Technologies and Intelligent Computing (ANTIC 2021), Institute of Science, Banaras Hindu University Varanasi, India, 17-18 December, 2021.  
  • [2021] Hemalatha Sasidharakurup, Anil Menon, Avinash Sreedharan Sabeen and Shyam Diwakar, Mathematical Modeling of Complex Cellular Networks of Autophagy-Lysosomal Pathway in Neurodegeneration, third International Conference on Advanced Computational and Communication Paradigms (ICACCP), Sikkim Manipal Institute of Technology, Sikkim, India, March 22 – 24, 2021.  
  • [2020] Hemalatha Sasidharakurup, Parvathy Devi Babulekshmanan, Sreehari Sathianarayanan and Shyam Diwakar, Modeling Crosstalk of Tau and ROS Implicated in Parkinson’s Disease using Biochemical Systems Theory, Proceedings of the 2nd International Conference on Cybernetics, Cognition and Machine Learning Applications, Goa, India, August 29-30, 2020. 
  • [2019] Hemalatha Sasidharakurup, Lakshmi Nair, Kanishka Bhaskar and Shyam Diwakar, Computational Modelling of TNFα Pathway in Parkinson’s Disease – A Systems Theory Perspective, Proceedings of the 8th international conference on Complex Networks and their Applications, Lisbon, Portugal, Dec 10-12, 2019. 
  • [2019] Sasidharakurup, Namitha Nalarajan, Meera Nair, Shibin Mubarak, Arathy Koranath and Shyam Diwakar, Computational model of convergent mechanisms in Alzheimer’s and Parkinson’s disease with insulin signalling using biochemical systems theory, Proceedings of the Third International Conference on Computing and Network Communications (CoCoNet’19), Trivandrum, Kerala, India, Dec 18-21, 2019. 
  • [2018] Sasidharakurup H., Nutakki C., Rajendran A., Venugopal P., Sumon M., Navaneethkumar L., Madhu H, Nair B., Diwakar S., Spectral Correlations in Speaker-Listener Behavior During a Focused Duo Conversation using EEG, Proceedings of the Seventh International Conference on Advances in Computing, Communications and Informatics (ICACCI-2018), Bangalore, Karnataka, India, Sept 19-22, 2018. 
     
  • [2018] Hemalatha Sasidharakurup, Malavika Pradeep, Maanasa Bhaskaran, Anu Priya, Evelin Pradeep, Shruthi Kadavath, Bipin Nair and Shyam Diwakar, Modeling of Glutamate Pathway in Alzheimer’s Disease using Biochemical Systems Theory, 2018 International Conference on Advances in Computing, Communications, and Informatics (ICACCI). 
  • [2017] Sasidharakurup H., Dash P., Nair B., Diwakar S., Computational Modelling of Apoptosis in Parkinson’s Disease using Biochemical Systems Theory, Proceedings of the Sixth International Conference on Advances in Computing, Communications and Informatics (ICACCI-2017, Manipal University,Karnataka, India, Sept 13-16,2017. 
  • [2016] Sasidharakurup H, Nair B, Diwakar S, Modeling of Biochemical Pathways in Parkinson’s Disease, XXXIV Annual Meeting of Indian Academy of Neurosciences (IAN), National Brain Research Center, Manesar, India, Oct 19-21, 2016. 
  • [2016] Sridharan A, Sasidharakurup H, Kumar D, Nizar N, Nair B, Achuthan K, Diwakar S. Implementing a Web-based Simulator with Explicit Neuron and Synapse Models to aid Experimental Neuroscience and Theoretical Biophysics Education, Proceedings of the International Conference on Signal, Networks, Computing, and Systems (ICSNCS 2016), Ed. Lobiya DK, Mohapatra DP, Nagar AK, Sahoo MN, Springer, 2016. 
  • [2016] Nutakki C, Nair A, Sasidharakurup H, Nair B, Achuthan K, Diwakar S., Low-Cost Robotic Articulator as an Online Education tool: Design, Deployment and Usage, Proceedings of IEEE International Conference on Robotics and Automation for Humanitarian Applications, Amrita University, Kollam, Kerala, Dec 18-20, 2016. 
  • [2015] Shyam Diwakar, Rakhi Radhamani, Hemalatha Sasidharakurp, Dhanush Kumar, Nijin Nizar, Krishnashree Achuthan, Bipin Nair, Assessing Students and Teachers Experience on Simulation and Remote Biotechnology Virtual labs: A Case Study with a Light Microscopy Experiment, Proceedings of 2nd International Conference on e-Learning e-Education and Online Training (eLEOT 2015), Novedrate, Italy, Sept 16-18, 2015. 
  • [2015] Diwakar S, Radhamani R, Sasidharakurup H, Kumar D, Nizar N, Achuthan K, Nair B, Role of ICT enabled Virtual Laboratories in Biotechnology Education: Case studies on blended and remote learning, Proceedings of 18th International Conference on Interactive Collaborative Learning, 2015 World Engineering Education Forum, Florence, Italy, Sept 20-24, 2015. 
  • [2015] Radhamani R., Sasidharakurup H., Kumar D., Nizar N., Achuthan K., Nair B., Diwakar S., Role of Biotechnology Simulation and Remotely Triggered Virtual labs in Complementing University Education, Proceedings of 9th International Conference on Interactive Mobile Communication Technologies and Learning, IMCL2015, Thessaloniki, Greece, 2015. 
  • [2015] Kumar D., Sasidharakurup H., Radhamani R., Nizar N., Achuthan K., Nair B., Diwakar S., Mobile Learning and Biotechnology Education via Remote Labs: Deployment-based study on Real Time-Shared Resources, Proceedings of 9th International Conference on Interactive Mobile Communication Technologies and Learning, IMCL2015, Thessaloniki, Greece, 2015. 
  • [2014] Rakhi Radhamani, Hemalatha Sasidharakurup, Gopika Sujatha, Bipin Nair, Krishnashree Achuthan and Shyam Diwakar. Virtual labs improve student’s performance in a classroom, Proceedings of 1st International Conference on e-Learning e-Education and Online Training, Bethesda, Maryland, United States, September 18–20, 2014. 
  • [2014] Radhamani R., Sasidharakurup H., Kumar D., Nizar N., Nair B., Achuthan K., Diwakar S., Explicit Interactions by Users Form a Critical Element in Virtual Labs Aiding Enhanced Education – A Case Study from Biotechnology Virtual Labs, Proceedings of International Conference on Technology for Education (IEEE T4E 2014), Kerala, December 18-21, 2014. 

Abstracts 

  • [2022] Hemalatha Sasidharakurup, Giovanni Naldi and Shyam Diwakar, Mathematical Modelling of Common Cellular Mechanisms in Parkinson’s and Alzheimer’s Diseases, 18th Annual Conference of the Italian Association of Cognitive Sciences (AISC), 15-17 December 2022, Rovereto, Trento – Italy. 
  • [2022] Hemalatha Sasidharakurup and Shyam Diwakar, Mathematical Modelling of Biochemical Networks in Neurodegenerative Diseases, 8th Annual Conference of Cognitive Science (ACCS8), 20-22 Jan 2022, Amrita Vishwa Vidyapeetham, Kerala. 
  • [2016] Sasidharakurup H, Nair B, Diwakar S, Modeling of Biochemical Pathways in Parkinson’s Disease, XXXIV Annual Meeting of Indian Academy of Neurosciences (IAN), Oct 19-21, 2016, National Brain Research Center, Manesar, India.  
  • [2014] Sasidharakurup H., Radhamani R., Nizar N., Achuthan K., Nair B., Diwakar S., Neuroscience Virtual Lab decreases teaching time and improves students’ perception in blended learning environment, Proceedings of the International symposium on Translational Neuroscience & XXXII Annual Conference of the Indian Academy of Neurosciences, Nov 1-Nov 3,2014, NIMHANS, Bangalore, India. 
  • [2013] Hemalatha Sasidharakurup, Akhila Shekhar, Bipin Nair, Krishnashree Achuthan, Shyam Diwakar. Testing the Role of Bioinformatics in University Education, in Amrtia BIOQUEST, Elsevier publications, Amrita University, Amritapuri, 2013. 
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