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Dr. Siby Gopinath

Professor, Department of Neurology, School of Medicine, Kochi

Qualification: DNB, MD, MNAMS
sibygopinath@aims.amrita.edu

Bio

Dr. Siby Gopinath is a Professor in the Department of Neurology, School of Medicine, Kochi. She completed her neurology residency from Amrita Institute of Medical Sciences, Kochi. Her special interest is in epilepsy sub-specialty, neuroelectrophysiology and sleep medicine. She underwent a specialised overseas training in epilepsy in Cleveland Clinic, Ohio and Toronto West Hospital, Canada. With this background she developed state-of-the-art Amrita Advanced Centre for Epilepsy (AACE) and Sleep Medicine, which subsequently became the largest epilepsy monitoring centre in the country and the first centre in the country to start a stereo-EEG program. It remains a centre with the highest number of stereo-EEGs done in the country. Stereo EEG is a minimally invasive technique (meaning not requiring open brain surgery) for recoding electrical activity from the brain and also for mapping the seizure and brain functions. She is currently Professor of Neurology and the director of Adult division of Epilepsy unit, at Amrita Advanced Centre for Epilepsy and Sleep medicine. She treats patients with epilepsy and has expertise in the management of patients with medically refractory epilepsy. Epilepsy surgery remains the mainstay of treatment for this difficult to treat group of epilepsy patients. She plays an integral role in the surgical treatment of epilepsy. Apart from the medical and surgical management, she is also experienced in treating epilepsy with dietary modifications (ketogenic diet), Deep Brain Stiumulation and minimally invasive surgical technique like radiofrequency ablation (a technique similar to Laser therapy).

Publications

Journal Article

Year : 2022

Outcome following surgery for insulo – opercular epilepsies

Cite this Research Publication : Jayapaul, Pushkaran, Siby Gopinath, and Ashok Pillai. "Outcome following surgery for insulo-opercular epilepsies", Journal of Neurosurgery 137, 5 (2022): 1226-1236

Year : 2022

Asymmetry index in anatomically symmetrized FDG PET improves epileptogenic focus detection in pharmacoresistant epilepsy

Cite this Research Publication : Aslam S, Damodaran N, Rajeshkannan R, Sarma M, Gopinath S, Pillai A., "Asymmetry index in anatomically symmetrized FDG PET improves epileptogenic focus detection in pharmacoresistant epilepsy," Journal of Neurosurgery, 2022 Aug 5;1-9.
doi: 10.3171/2022.6.JNS22717.

Year : 2022

Localizing epileptogenic network from SEEG using non-linear correlation, mutual information and graph theory analysis.

Cite this Research Publication : Devisetty R, Amsitha MB, Jyothirmai S, Ajai R, Pillai A, Kumar A, Gopinath S and Parasuram H, "Localizing epileptogenic network from SEEG using non-linear correlation, mutual information and graph theory analysis," Journal of Engineering in Medicine, 8 Nov 2022, 236(12):1783-1796, DOI: 10.1177/09544119221134991

Year : 2022

Retrospective analysis of autonomic dysfunction in epilepsy patients from neurophysiological recordings

Cite this Research Publication : A Shridharani,H. Parasuram, B. Mrudula,R.Bhaskaran, A. Kumar & S.Gopinath, "Retrospective analysis of autonomic dysfunction in epilepsy patients from neurophysiological recordings," Neurology Asia, Vol. 27 No. 3 (2022). DOI: https://doi.org/10.54029/2022mpp

Year : 2021

Predicting Autonomic Dysfunction in Anxiety Disorder from ECG and Respiratory Signals Using Machine LearningModels

Cite this Research Publication : AS George, AV Kurup, P Balachandran, M Nair, S Gopinath, A Kumar and H Parasuram, Predicting Autonomic Dysfunction in Anxiety Disorder from ECG and Respiratory Signals Using Machine LearningModels. International Journal of Online & Biomedical Engineering 17 (7), 2021

Publisher : International Journal of Online & Biomedical Engineering

Year : 2021

Current practices in epilepsy monitoring units (EMU) in India

Cite this Research Publication : Baheti N., Rathore C., Bansal A. R., Kannan L., Gopinath S., Pillai A., Jagtap S., Patil S., Jabeen S. A., Suryaprabha T., Jayalakshmi S., "Current practices in epilepsy monitoring units (EMU) in India," Seizure, 2021 Dec 1;93:13-9, DOI: 10.1016/j.seizure.2021.10.004

Year : 2021

Reiterating the role of corpus callosum in generalization of interictal and ictal epileptiform discharges: a case report with post-callosotomy intracranial electroencephalography in Lennox–Gastaut syndrome

Cite this Research Publication : Gopinath S., Pillai A., Diwan A.G., Pattisapu J.V., Radhakrishnan K., "Reiterating the role of corpus callosum in generalization of interictal and ictal epileptiform discharges: a case report with post-callosotomy intracranial electroencephalography in Lennox–Gastaut syndrome," Epilepsy and paroxysmal conditions. 2021;13(3):249-253. https://doi.org/10.17749/2077-8333/epi.par.con.2021.086

Year : 2021

Predicting Autonomic Dysfunction in Anxiety Disorder from ECG and Respiratory Signals Using Machine Learning Models

Cite this Research Publication : Abhilash Saj George, Arjun Vijayanatha Kurup, Parthasarathy Balachandran, Manjusha Nair, Siby Gopinath, Anand Kumar, Harilal Parasuram Parasuram. Predicting Autonomic Dysfunction in Anxiety Disorder from ECG and Respiratory Signals Using Machine Learning Models, International Journal of Online & Biomedical Engineering, 17 (7), 2021, DOI: https://doi.org/10.3991/ijoe.v17i07.22581

Year : 2021

Quantification of epileptogenic network from Stereo EEG recordings using Epileptogenicity Ranking method

Cite this Research Publication : Parasuram H, Gopinath S, Pillai A, Diwakar S, Kumar A., Quantification of epileptogenic network from Stereo EEG recordings using Epileptogenicity Ranking method, Front. Neurol., 03 November 2021, https://doi.org/10.3389/fneur.2021.738111

Publisher : Frontiers in Neurology

Year : 2021

Impact of COVID-19 pandemic on epilepsy practice in India: A tripartite survey

Cite this Research Publication : C. Rathore, Baheti, N., Bansal, A. Ram, Jabeen, S. Afshan, Siby Gopinath, Jagtap, S., Patil, S., Suryaprabha, T., Jayalakshmi, S., Ravat, S., Nayak, D. S., Prakash, S., Rana, K., Jaiswal, S. K., Khan, F. R., Murthy, J. Mk, and Radhakrishnan, K., “Impact of COVID-19 pandemic on epilepsy practice in India: A tripartite survey.”, Seizure, vol. 86, pp. 60-67, 2021.

Year : 2020

Epileptic nystagmus due to a large parieto‐temporo‐occipital multilobar dysplasia

Cite this Research Publication : Jayakumar H, Gopinath S, Pillai A, Kumar A., "Epileptic nystagmus due to a large parieto‐temporo‐occipital multilobar dysplasia," Epileptic Disorders, 2020 Oct; 22(5):691-2.

Year : 2019

Comparison of clinical and electrophysiological characteristics of ictal asystole and cardiac asystole encountered during video-electroencephalographic monitoring

Cite this Research Publication : Sankaranarayanan, Muthukani; Makhija, Prashant; Gopinath, Siby; Mathew, Navin; Radhakrishnan, Kurupath, "Comparison of clinical and electrophysiological characteristics of ictal asystole and cardiac asystole encountered during video-electroencephalographic monitoring," Epileptic Disord, 2019 Aug 1;21(4):337-346. doi: 10.1684/epd.2019.1085.

Year : 2018

Use of cutaneous silent period parameters as a diagnostic indicator in patients with restless legs syndrome-a study in south Indian population

Cite this Research Publication : Alexander R., Saraswathy L, Gopinath S., "Use of cutaneous silent period parameters as a diagnostic indicator in patients with restless legs syndrome-a study in south Indian population," International Journal of Medical Research and Review, February, 2018/ Vol 6/Issue 02, DOI: https://doi.org/10.17511/ijmrr.2018.i02.07

Year : 2018

Expanding spectrum of contactin-associated protein 2 (CASPR2) autoimmunity-syndrome of parkinsonism and ataxia.

Cite this Research Publication : S. Kannoth, Nambiar, V., Gopinath, S., Anandakuttan, A., Mathai, A., and Rajan, P. Kanjiraman, “Expanding spectrum of contactin-associated protein 2 (CASPR2) autoimmunity-syndrome of parkinsonism and ataxia.”, Neurological Sciences, vol. 39, no. 3, pp. 455-460, 2018.

Publisher : Neurol Sci

Year : 2017

A Cross-sectional, Multicenter Study to Determine the Socio Expanding spectrum of contactin-associated protein 2 (CASPR2) autoimmunity-syndrome of parkinsonism and ataxia

Cite this Research Publication : Kannoth S, Nambiar V, Gopinath S, Anandakuttan A, Mathai A, Rajan PK, "A Cross-sectional, Multicenter Study to Determine the Socio Expanding spectrum of contactin-associated protein 2 (CASPR2) autoimmunity-syndrome of parkinsonism and ataxia", Neurological Sciences, 2018 Mar;39(3):455-460. doi: 10.1007/s10072-017-3222-0. Epub 2017 Dec 20.

Year : 2017

Role of magnetoencephalography and stereo-electroencephalography in the presurgical evaluation in patients with drug-resistant epilepsy

Cite this Research Publication : V Jayabal, Ashok Pillai, S Sinha, N Mariyappa, P Satishchandra, S Gopinath, Kurupath Radhakrishnan, "Role of magnetoencephalography and stereo-electroencephalography in the presurgical evaluation in patients with drug-resistant epilepsy," Neurology India, March 2017: 65(S1): 34-44, DOI: 10.4103/0028-3886.201680.

Year : 2017

Delayed orthostatic hypotension: A pilot study from India

Cite this Research Publication : Arun Grace Roy, Siby Gopinath, Suresh Kumar, Sudheeran Kannoth, Anand Kumar, "Delayed orthostatic hypotension: A pilot study from India," Annals of Indian Accademy of Neurology 2017/ 20/3/248-251, doi: 10.4103/aian.AIAN_498_16

Year : 2017

A case of post-leptospirosis autoimmune epilepsy presenting with sleep-related hypermotor seizures.

Cite this Research Publication : P. Makhija, Gopinath, S., Kannoth, S., and Radhakrishnan, K., “A case of post-leptospirosis autoimmune epilepsy presenting with sleep-related hypermotor seizures.”, Epileptic Disord, vol. 19, no. 4, pp. 456-460, 2017, DOI: 10.1684/epd.2017.0941

Year : 2016

Seizure outcome following primary motor cortex-sparing resective surgery for perirolandic focal cortical dysplasia.

Cite this Research Publication : S. Gopinath, Roy, A. Grace, Vinayan, K. Puthenveet, Kumar, A., Sarma, M., Rajeshkannan, R., and Pillai, A., “Seizure outcome following primary motor cortex-sparing resective surgery for perirolandic focal cortical dysplasia.”, Int J Surg, vol. 36, no. Pt B, pp. 466-476, 2016.

Year : 2015

Clinical Profile of Narcolepsy in Children in India

Cite this Research Publication : Roy Arun Grace, Gopinath Siby, Kumar Suresh, Singh Dinesh, Nampoodiri Sheela, Vinayan KP, Kumar Anand, Einen MaliA, Mignot Emmanuel, "Clinical profile of narcolepsy in children in India," Indian Journal of Sleep Medicine 2015/Vol 10/ 2/74-78, DOI No:10.5958/0974-0155.2015.00011.X

Year : 2015

Efficacy of custom made oral appliance for treatment of obstructive sleep apnea

Cite this Research Publication : Va Cilil, K., S. Varma N., Siby Gopinath, and V., A. V., “Efficacy of custom made oral appliance for treatment of obstructive sleep apnea”, Contemporary Clinical Dentistry, vol. 6, pp. 341-347, 2015.

Publisher : Medknow Publications

Year : 2015

Effect of rapid maxillary expansion on sleep characteristics in children

Cite this Research Publication : Navya Ashok, Sapna Varma N. K., Ajith V. V., Siby Gopinath, "Effect of rapid maxillary expansion on sleep characteristics in children," Contemporary Clinical Dentistry 2014: Vol5/ issue 4: Pages 489-494.

Publisher : Medknow Publications

Year : 2012

A rare case of chronic hyperventilation due to brain stem tumour

Cite this Research Publication : , Siby Gopinath, V, R., and KS, K. Indira, “A rare case of chronic hyperventilation due to brain stem tumour”, Pulmon , 2012.


Year : 2011

A comprehensive approach to the management of birth injuries of the brachial plexus

Cite this Research Publication : Pillai A, Vijayaraghavan S, Kishore P, Gopinath S, Roy AG, Surendran K, Ranjit TC., "A comprehensive approach to the management of birth injuries of the brachial plexus," (Abstract published), Childs Nervous System (2011) 27:1766-67.

Year : 2011

Infectious psychosis: Cryptococcal meningitis presenting as a neuropsychiatry disorder

Cite this Research Publication : Anil Kumar, Siby Gopinath, Kavitha R Dinesh, Shamsul Karim , "Infectious psychosis: Cryptococcal meningitis presenting as a neuropsychiatry disorder," Neurology India 2011: Vol: 59: Issue 6: Page 909-911.

Year : 2009

Isomorphic and Isotopic phenomenon occurring simultaneously in a case of granuloma annulare

Cite this Research Publication : Feroze Kaliyadan, Siby Gopinath, MG Jayasree, Chirag Parmar, "Isomorphic and Isotopic phenomenon occurring simultaneously in a case of granuloma annulare;" Indian Journal of Dermatology Venereology and Leprology; 2009;75;307-309.

Year : 2007

Nasal cure for myopathy – A neuroendocrine puzzle

Cite this Research Publication : Siby Gopinath, Syam UK, "Nasal cure for myopathy - A neuroendocrine puzzle?", Amrita Journal of Medicine; 2007.

Conference Paper

Year : 2018

Localization of Epileptogenic Zone: A Graph Theoretical Approach

Publisher : Proceedings of International Conference on Vision, Image and Signal Processing (ICVISP)

Qualification
  • Training in epilepsy
    Cleveland Clinic Ohio Toronto
  • Training in epilepsy
    West Hospital, Canada
  • Training in high-density EEG
    University Hospital, Geneva under Dr. Margitta Seeck
  • DNB
  • MD
Work Experience
  • 16 years of expertise in the field of epilepsy and neurology
Area of Expertise
  • Epilepsy
  • Neuroelectrophysiology
  • Sleep medicine
  • Electroencephalography
  • Stereo-EEG (intracranial EEG)
  • Functional brain mapping including seizure mapping, functional mapping, neurostimulation techniques
  • Narcolepsy and sleep apnea.
  • She has successfully established the intra-operative neurophysiology program
Awards and Recognition
  • World’s Best Epileptologist.
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