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Dr. Prasanna Ramani

Associate Professor

Dr. Prasanna Ramani currently serves as Associate Professor in Chemistry, Department of Sciences, School of Engineering, Coimbatore. His areas of research include Medicinal Chemistry, Combinatorial Chemistry, Peptide Chemistry, Natural Product Chemistry, Organometallic Chemistry.

Qualification: MSc, Ph.D
r_prasanna1@cb.amrita.edu
Research Interest: Combinatorial Chemistry, Drug Delivery, Medicinal Chemistry, Natural Product Chemistry, Peptide Chemistry

Bio

Dr. Prasanna Ramani did his master’s degree in Chemistry from Bharathidasan University, India and Ph. D. in Chemical Sciences from University of Milan, Italy.

His doctoral thesis work was focused on Synthesis/labeling of Modified Peptide Nucleic Acids (artificial DNA) and their Analytical Properties. Dr. Ramani worked on polymer chemistry, total synthesis of natural products and functionalization of CNTs during his tenure as a postdoctoral researcher at Center for bio-molecular Interdisciplinary Studies and Industrial applications (CISI), University of Milan, Italy. His postdoctoral research was supported by UNESCO grant from University of Trieste, Italy.

Before his doctoral studies, Dr. Ramani worked for three years as Senior Chemist at Orchid Chemicals and Pharmaceuticals Ltd., Chennai, India. He has organized, participated and presented in various meetings and workshops around India and Europe.

Dr. Ramani is also guiding a number of undergraduate & postgraduate student projects and Ph. D. research scholars. He currently researches on synthesis of biologically interesting molecules and natural product chemistry.

EDUCATION

YEAR DEGREE/PROGRAM INSTITUTION
December 2006 Doctoral Degree University of Milano, Italy
August 2000 Postgraduate Degree Bishop Heber College, Bharathidasan University, Trichy
July 1998 Undergraduate Degree Bishop Heber College, Bharathidasan University, Trichy

EXPERIENCE

YEAR AFFILIATION
March 2009 – Present Assistant Professor (SG),   Department of Sciences, Amrita Vishwa Vidyapeetham
Sep 2006– Feb 2007 Research Associate, University of Milano, Italy.
Feb 2007 –Feb 2009 Post-doctoral fellow, Centre for bio-molecular Interdisciplinary Studies and Industrial applications (CISI), University of Milan, Italy
Sep 2000 – June 2003 Research Chemist, Orchid Chemicals and Pharmaceuticals Ltd., Chennai

Research

The research team targets on the synthesis of new molecules that can target cancer. Cancer results from mutation of certain genes that allow the cells to begin their uncontrolled growth. These mutations are inherited or acquired. The group members intend to find a possible solution towards cancer free world. The following are our Research interests:

  • Peptide Nucleic Acids:

The remarkable binding properties of ‘Peptide Nucleic Acids’ (PNA), the so called artificial DNAs, have spawned a rapidly expanding new field of research and their applications as therapeutics, DNA diagnostics, tools in biotechnology and much more. PNA is linked to various scientific disciplines, few includes medicinal chemistry, biochemistry, molecular biology, immunology and drug development. Our focus is to improve the solubility and sensitivity to detect complementary natural nucleobases.

  • Medicinal Chemistry:

Endangered Plants:

Herbal medicines are assumed to be of great importance in the primary health care of individual and communities. The World Health Organization has estimated that 80% of the population of developing countries still relies on traditional medicines, mostly plant drugs, for the primary health care needs. The high degree of efficacy and safety with herbal medicines make them more acceptable compared to other therapeutic invention. Plant-based traditional knowledge has become a recognized tool in search for new sources of drugs and neutraceuticals. Our basic aim is to identify the plants which are on the verge of extinction and find the medicinal value of that plant, which can be used by us in our day today life.

Anti-Cancer molecules:

Alkaloids are a class of naturally occurring organic nitrogen containing compounds. Typical alkaloids are derived from plant sources, they are basic, they contain one or more nitrogen atoms (usually in a heterocyclic ring) and they usually have a marked physiological action on man or other animals. Alkaloids have potent anticancer activity against various cancers. Our intentions are to synthesis some alkaloids and study their biological properties.

  • Combinatorial chemistry:

In this, our research has been focused on the design and synthesis of small molecules towards human carcinoma. This work is in collaboration with Dr. Krishnan Namboori of Computational Chemistry Group. Molecules generated through computer-assisted molecular design will be screened for synthetic feasibility. Selected molecules will be synthesized in our laboratory and subjected to biological evaluation.

  • Drug Delivery:

Sustained Drug Delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in human system as needed to safely achieve its desired therapeutic effect. This can be attained by maintaining a constant drug concentration for a specific period of time with minimum side effect. Most pharmaceutical drugs in the market are encapsulated with gelatin, which is manufactured from the collagen of animal skin or bone. The target in this research is to find an alternative means of encapsulating those drugs for sustained release.

Projects

Peer Reviewed International Journals (Under Review)

  1. Sathianarayanan, S., Amrutha B Chittethu, Asha Jose, Ranganathan, B., Saranya, T.S, Asha Asokan, M., Ramani. P., “Design And Synthesis Of Isatin Semicarbazone Derivatives Against Mammary Carcinoma Cells”, Medicinal Chemistry Research (Under Review); IF: (1.6)
  2. Nancy Thomas, Subin Mary Zachariah, Ramani. P., “4-Aryl-4H-chromene-3-carbonitrile derivates: Synthesis and preliminary anti-breast cancer studies”, Journal of Heterocyclic Chemistry, (Accepted); IF: (0.8)
  3. Athira Rajan K.V, Shilpa G. S, Ramani. P., “ Biological Importance Of Pyrrole”, Journal of Environmental Nanotechnology (Accepted); IF: (0.6)
  4. Silpa K, Ramani. P., Shilpa G.S., “Applications Of Fluorescent Makers”, Journal of Environmental Nanotechnology (Accepted); IF: (0.6)
  5. Pavithra E.R, Arun M, Anirudh Swaminathan R, Muthubalaji Vishwanath S.M, Murali Rangarajan, Nikhil Kothurkar, Ramani. P., “Synthesis of zeolites using polyethylene glycol as binder for biological applications”, Procedia Chemistry, (Accepted);
  6. Nancy Thomas, Subin Mary Zachariah, Ramani. P., “Synthesis, Anti-Oxidant and Anti-Inflammatory Studies Of Substituted Chromene – A Preliminary Anti-Cancer Study”, Procedia Chemistry, (Accepted)

Reviewer – Journals

  • Tetrahedron Letters – Elsevier,
  • Bio-organic and medicinal chemistry – Elsevier,
  • Journal of heterocyclic chemistry – Springer,
  • Journal of Advanced Pharmaceutical Technology and Research – Medknow,

Other Academic/Non-Academic Activities

  1. Member, Board of Studies, Five-year Integrated M.Sc Chemistry, Department of Sciences, Amrita Vishwa Vidyapeetham.

Honors

  1. Awarded “Recognized reviewer Status” from Elsevier
  2. Young scientist award received from Department of Science and Technology, India (2013).
  3. Recipient of UNESCO grant in collaboration with ICTP to pursue Post-doctoral research at CISI, Univ. of Milan, Italy (Feb 07 – Feb 09).
  4. Recipient of grant to work as a “Research Associate” from University of Bari, Italy (Sep06—Feb07)
  5. Young researcher award at ―XXX “A. Corbella” Summer School held at Gargnano, Italy (June 2005)
  6. Italian Chemical Society (SCI) grant to participate at the ―First Austrian—German— Italian meeting of Organic Chemistry held at Vienna, Austria (April 2005)
  7. Member of Italian Chemical Society (SCI) since 2003
  8. Awarded financial assistantship in Non-EU category by University of Milan, Italy, for pursuing Doctoral research (2003—2006).

Membership in Professional Bodies

  1. Italian Chemical Society (SCI) since 2003

Teaching (PG/PhD Courses)

  • PG Course 3
  • PhD Course 3

Student Guidance

Doctoral Students

  1. Development of Modified and Labeled Peptide Nucleic Acid Oligomers for DNA Recognition”, Shilpa G.S. Ongoing  
  2. Modified Arecoline Derivatives: Synthesis and Preliminary Anti-Cancer Studies”, Baladhandapani A. Ongoing

Master’s Students

  1. Design, Synthesis and Biological Evaluation of Anti-Prostate Cancer Agents”, Harikrishnan K. V (M.Pharm), 2013.
  2. Fragment Based Drug Design, Synthesis and Evaluation of Anti-Cancer Drugs Targeted on Breast Cancer Proteins”, Vijith V.S (M.Pharm), 2013.
  3. “Synthesis of 3-isopropyl-2-methoxymethyl pyrrole for anti-pancreatic cancer”, Athira Rajan K.V (M.Sc), 2015
  4. “Synthesis of Labeled Peptide Nucleic Acid Monomers and its analytical studies”  Silpa K (M.Sc), 2015

Bachelor’s Students (B.Tech)

  1. “Design, Synthesis and Biological Analysis of modified Arecoline”, Kirti G Pillai, Varun S K, Department of Chemical Engineering and Material Sciences, 2014.
  2. “Continuous Pyrolysis of Plastic in a Catalytic Fixed Bed Reactor”, Anirudh S., Arun M., Muthubalaji Vishwanath S.M., Pavithra E.R., 2014 (Dr. Murali Rangarajan, Dr. Nikhil Kothurkar, Dr. Udaya Baskar Reddy Ragula).
  3. “Novel Pathway To Synthesise Key Intermediate To Benzophenanthridines: Photoreduction Of Nitro Naphthalenes”, Atulya Varma, Himanshu Goyal, Manoj Sundar C. A., Department of Chemical Engineering and Material Sciences, 2012.
  4. Synthesis and modelling of Labelled Peptide Nucleic Acids”, Sharmila S, Sindhura Reddy N, Sre Vinojaa T, Nandhini M, Department of Chemical Engineering and Material Sciences, 2011.

Conferences/Seminar/Guest Lecture

  • Participated as a Resource Person in a One Day National Seminar on Spectral Analysis in Pharmaceutical Research was organized at Amrita School of Pharmacy on March 22, 2010.
  • Given a Lecture on Overview of NMR Spectroscopy and Interpretation, at Amrita School of Pharmacy on Feb 22-23, 2010.
  • Lecture on Microwave in Organic Synthesis given at Avinashilingam University, Coimbatore.

Workshop Attended

  • Participated in an International Workshop on Solid State NMR, Organized by TIFR- RAC- Ooty during Jan 4- 8, 2010.
Publications

Journal Article

Year : 2020

Antioxidant and cytotoxic activities of Indian caper (Capparis brevispina DC (Capparaceae)) leaf extracts

Authors : Dr. Prasanna Ramani, Selva Kumar Subramanian;

Publisher : European Journal of Integrative Medicine

S. Kumar Subramanian and Ramani, P., “Antioxidant and cytotoxic activities of Indian caper (Capparis brevispina DC (Capparaceae)) leaf extracts”, European Journal of Integrative Medicine, vol. 33, p. 101038, 2020.

Year : 2016

4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies

Authors : Dr. Prasanna Ramani, Dr. Subin Mary Zachariah, Na Thomas

Publisher : HeteroCorporation

Na Thomas, Dr. Subin Mary Zachariah, and Dr. Prasanna Ramani, “4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies”, Journal of Heterocyclic Chemistry, vol. 53, no. 6, pp. 1778-1782, 2016.

Year : 2015

Applications of Fluorescent Makers

Authors : Dr. Prasanna Ramani, K. Silpa, and Shilpa, G. S.

Publisher : J. Environ. Nanotechnol

Year : 2013

Design of Novel Drug Molecules for the Treatment of Breast Cancer

Authors : Dr. Prasanna Ramani, Vijith, V. S., Harikrishnan, K. V., Krishnapriya, S., Varma, V., Jose, A., Kumar, E. P., and P.K., K. Namboori

Publisher : International Journal of Pharmaceutical Sciences Review and Research

Year : 2008

A new synthetic approach to 7-hydroxynitidine

Authors : Dr. Prasanna Ramani, Fontana, G.

Publisher : Tetrahedron Letters

Dr. Prasanna Ramani and Fontana, G., “A new synthetic approach to 7-hydroxynitidine”, Tetrahedron Letters, vol. 49, pp. 5262 - 5264, 2008.

Year : 2007

Synthesis of new water soluble electrochemically active probes for biomolecules

Authors : Dr. Prasanna Ramani, C. Baldoli, Oldani, C., Licandro, E., Valerio, A., Ferruti, P., Falciola, L., and Mussini, P.

Publisher : 2007.

Year : 2007

Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules

Authors : Dr. Prasanna Ramani, C. Baldoli, Oldani, C., Licandro, E., Valerio, A., Ferruti, P., Falciola, L., and Mussini, P

Publisher : Journal of Organometallic Chemistry

C. Baldoli, Oldani, C., Licandro, E., Dr. Prasanna Ramani, Valerio, A., Ferruti, P., Falciola, L., and Mussini, P., “Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules”, Journal of Organometallic Chemistry, vol. 692, pp. 1363 - 1371, 2007.

Year : 2004

A new ferrocene Conjugated of a tyrosine PNA monomer synthesis and electrochemical properties

Authors : Dr. Prasanna Ramani, Baldoli, C., Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Rigamonti, C., and Zinzalla, G.

Publisher : Journal of Organometallic Chemistry

Dr. Prasanna Ramani, Baldoli, C., Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Rigamonti, C., and Zinzalla, G., “A new ferrocene Conjugated of a tyrosine PNA monomer synthesis and electrochemical properties”, Journal of Organometallic Chemistry, 2004.

Year : 2004

A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties

Authors : Dr. Prasanna Ramani, C. Baldoli, Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Rigamonti, C., and Zinzalla, G.

Publisher : Journal of Organometallic Chemistry

C. Baldoli, Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Dr. Prasanna Ramani, Rigamonti, C., and Zinzalla, G., “A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties”, Journal of Organometallic Chemistry, vol. 689, pp. 4791 - 4802, 2004.

Conference Paper

Year : 2018

Synthesis, Antioxidant and Anti-inflammatory Studies of Substituted Chromene – A Preliminary Anti-Cancer study

Authors : Dr. Subin Mary Zachariah, Dr. Prasanna Ramani, Thomas, N

Publisher : Elsevier Ltd

cited By 0; Conference of 2016 International Conference on Advanced Materials, SCICON 2016 ; Conference Date: 19 December 2016 Through 21 December 2016; Conference Code:138807

Conference Proceedings

Year : 2015

Role of pyrrole in biological systems

Authors : Dr. Prasanna Ramani, A. Rajan K.V, and S, S. G.

Publisher : Recent trends in Medicinal Chemistry

Year : 2015

Applications Of Markers

Authors : Dr. Prasanna Ramani, S. K, and G.S, S.

Publisher : Recent trends in Medicinal Chemistry

Year : 2014

Synthesis of zeolites using polyethylene glycol as binder for biological applications

Authors : Dr. Prasanna Ramani, P. E.R, Arun M, R, A. Swaminatha, S.M, M. Vishwanath, Rangarajan, M., and Kothurkar, N.

Publisher : Emerging Trends in Drug Discovery – AICADD 2014

Year : 2014

Synthesis and Analysis of Efficient Drug Delivery System using Sulphonated-Polyetheretherketone

Authors : Dr. Prasanna Ramani, K, P., S, S., K, R., and S, G.

Publisher : 2nd International Conference on Emerging Trends in Chemical and Pharmaceutical Sciences

Book Chapter

Year : 2011

Peptide Nucleic Acids and Markers

Authors : Dr. Prasanna Ramani

Publisher : Academic Publishers

Dr. Prasanna Ramani, “Peptide Nucleic Acids and Markers”, in Academic Publishers, 2011.

Patents

Year : 2019

Peptide Nucleic Acid monomers and a preparation method

Authors : Dr. Prasanna Ramani

P. Ramani, “Peptide Nucleic Acid monomers and a preparation method”, 2019.

Year : 2017

Peptide Nucleic Acid monomers and a preparation method thereof

Authors : Dr. Prasanna Ramani

Publisher : Indian Patent application, Filed, Number 201741020193 (2017)

P. Ramani, “Peptide Nucleic Acid monomers and a preparation method thereof”, U.S. Patent 2017410201932017.

Year : 2017

An Improved Process To Prepare Malonic Acid Derivatives Using Meldrum’s Acid

Authors : Dr. Prasanna Ramani, Prof. Bipin Nair

Publisher : Indian Patent application, Filed, Number 201741018917

P. Ramani and Nair, B., “An Improved Process To Prepare Malonic Acid Derivatives Using Meldrum’s Acid”, U.S. Patent 2017410189172017.

Year : 2015

Methods and Formulations for Screening and Treatment of Prostate Cancer

Authors : Dr. Prasanna Ramani, PK, K. Namboori

Publisher : U.S. Patent

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