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Dr. Prasanna Ramani

Professor, Department of Chemistry, School of Physical Sciences, Coimbatore

Qualification: MSc, Ph.D
r_prasanna1@cb.amrita.edu
Google Scholar Profile
Research Interest: Combinatorial Chemistry, Drug Delivery, Medicinal Chemistry, Natural Product Chemistry, Peptide Chemistry

Bio

Dr. Prasanna Ramani is the Head of Dhanvanthri laboratory and Professor at the Department of Chemistry, Amrita School of Physical Sciences, Coimbatore campus.

He holds a doctoral degree in Chemical Sciences from University of Milano, Italy and has worked as Postdoctoral Researcher at Center for bio-molecular Interdisciplinary Studies and Industrial applications (CISI), University of Milan, Italy. His postdoctoral research was supported by UNESCO grant from University of Trieste, Italy. Prior his postdoctoral research, he worked as a Research Assistant at University of Milano for a year. Before his doctoral studies, he worked for Orchid Chemicals and Pharmaceuticals Ltd., Chennai, India for three years.
Dr. Ramani is also guiding a number of undergraduate & postgraduate student projects and Ph. D. research scholars. He currently researches on synthesis of biologically interesting molecules and natural product chemistry.

Publications

Journal Article

Year : 2023

Exploration of N-Tetra-Substituted Imidazoles as Effective Agents To Counteract Gastric Cancer Cell Viability: Synthesis and Biological Evaluation

Cite this Research Publication : Bharathi Hassan Ganesh, Dr. Baladhandapani Aruchamy, Dr. Prasanna Ramani, Prof. Susi Zara, Prof. Simone Carradori, Dr. Silvia D'Agostino, Prof. Bijo Mathew, Exploration of N-Tetra-Substituted Imidazoles as Effective Agents To Counteract Gastric Cancer Cell Viability: Synthesis and Biological Evaluation, https://doi.org/10.1002/slct.202302768 (First published: 21 December 2023)

Year : 2023

Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure-Activity Relationship

Cite this Research Publication : Bharathi Hassan Ganesh, Anirudh G. Raj, Dr. Baladhandapani Aruchamy, Dr. Pandurangan Nanjan*, Dr. Carmelo Drago, Dr. Prasanna Ramani*, Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure-Activity Relationship, https://doi.org/10.1002/cmdc.202300447 (First published: 05 November 2023 )

Year : 2023

Design, Synthesis, and Anti-Breast Cancer Potential of Imidazole–Pyridine Hybrid Molecules In Vitro and Ehrlich Ascites Carcinoma Growth Inhibitory Activity Assessment In Vivo

Cite this Research Publication : Baladhandapani Aruchamy, Mahadevaswamy G. Kuruburu, Venugopal R. Bovilla, SubbaRao V. Madhunapantula, Carmelo Drago, Sonu Benny, Aneesh Thankappan Presanna, and Prasanna Ramani, Design, Synthesis, and Anti-Breast Cancer Potential of Imidazole–Pyridine Hybrid Molecules In Vitro and Ehrlich Ascites Carcinoma Growth Inhibitory Activity Assessment In Vivo, ACS Omega 2023, 8, 43, 40287–40298, https://doi.org/10.1021/acsomega.3c04384 (Publication Date: October 19 2023)

Publisher : ACS

Year : 2023

Sulfonated Polyether Ketone Membranes Embedded with Nalidixic Acid—An Emerging Controlled Drug Releaser

Cite this Research Publication : Padinjarathil, Himabindu, Vidya Vilasini, Rajalakshmi Balasubramanian, Carmelo Drago, Sandro Dattilo, and Prasanna Ramani. 2023. "Sulfonated Polyether Ketone Membranes Embedded with Nalidixic Acid—An Emerging Controlled Drug Releaser" Polymers 15, no. 17: 3631. (Published: 1 September 2023)

Year : 2023

Development of new cobalt, copper, and zinc complexes of Schiff-base ligands as prospective chemotherapeutic agents

Cite this Research Publication : Vigneswari Sankara Narayanan, Archana Rajendran, Srikrishna Mudradi, Soven Dhawa, Sreeja Rajendran, Kondapa Naidu Bobba, Jeya Rajendran, Prasanna Ramani, Development of new cobalt, copper, and zinc complexes of Schiff-base ligands as prospective chemotherapeutic agents, Polyhedron, Volume 245, 2023, 116622, ISSN 0277-5387 , 2.6 Impact Factor

Year : 2023

Evolution and clinical advances of platelet-rich fibrin in musculoskeletal regeneration

Cite this Research Publication : Ragunanthan Narayanaswamy, Bishnu Prasad Patro, Naveen Jeyaraman, Prakash Gangadaran, Ramya Lakshmi Rajendran, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Prasanna Ramani, Byeong-Cheol Ahn, "Evolution and clinical advances of platelet-rich fibrin in musculoskeletal regeneration", Bioengineering Volume 10 Issue 1 Pages 58, 2023

Publisher : MDPI

Year : 2023

Imidazole-pyridine hybrids as potent anti-cancer agents

Cite this Research Publication : Baladhandapani Aruchamy, Carmelo Drago, Venera Russo, Giovanni Mario Pitari, Prasanna Ramani, TP Aneesh, Sonu Benny, VR Vishnu, "Imidazole-pyridine hybrids as potent anti-cancer agents", European Journal of Pharmaceutical Sciences Volume 180 Pages 106323, 2023

Publisher : Elsevier

Year : 2023

Enhancement of physicochemical properties, antioxidant, antitumor, and anticoagulant activities via acetylation of Hypsizygus ulmarius polysaccharide

Cite this Research Publication : Alamelu Thimmaraju, Sudha Govindan, Archana Rajendran, Prasanna Ramani, Mirian Pateiro, José M Lorenzo, "Enhancement of physicochemical properties, antioxidant, antitumor, and anticoagulant activities via acetylation of Hypsizygus ulmarius polysaccharide", International Journal of Food Science & Technology, 2023

Publisher : International Journal of Food Science & Technology

Year : 2023

Design of an Antibiotic-Releasing Polymer: Physicochemical Characterization and Drug Release Patterns

Cite this Research Publication : Himabindu Padinjarathil, Srikrishna Mudradi, Rajalakshmi Balasubramanian, Carmelo Drago, Sandro Dattilo, Nikhil K Kothurkar, Prasanna Ramani, "Design of an Antibiotic-Releasing Polymer: Physicochemical Characterization and Drug Release Patterns", Membranes Volume 13 Issue 1 Pages 102, 2023

Publisher : MDPI

Year : 2023

Antidiabetic activity of polysaccharide from Hypsizygus ulmarius in streptozotocin-nicotinamide induced diabetic rats

Cite this Research Publication : Sudha Govindan, Jayasakthi Shanmugam, Gayathri Rajendran, Prasanna Ramani, Devaki Unni, Bharathiraja Venkatachalam, Amal Janardhanan, Kathir Aswini, Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn, "Antidiabetic activity of polysaccharide from Hypsizygus ulmarius in streptozotocin-nicotinamide induced diabetic rats", Bioactive Carbohydrates and Dietary Fibre Volume 29 Pages 100350, 2023

Publisher : Elsevier

Year : 2023

Protective effect of aqueous extract of Pleurotus eous against Dalton’s lymphoma ascites tumor in mice

Cite this Research Publication : Vadivukkarasi Sasikumar, Sudha Govindan, Gayathri Rajendran, Archana Rajendran, Prasanna Ramani, Mirian Pateiro, José M Lorenzo, "Protective effect of aqueous extract of Pleurotus eous against Dalton's lymphoma ascites tumor in mice", Journal of Agriculture and Food Research Volume 13 Pages 100638, 2023

Publisher : Elsevier

Year : 2022

Sulfated modification, characterization and bioactivities of an acidic polysaccharide fraction from an edible mushroom Pleurotus eous (Berk.) Sacc.

Cite this Research Publication : Sasikala Gunasekaran, Sudha Govindan, Prasanna Ramani, "Sulfated modification, characterization and bioactivities of an acidic polysaccharide fraction from an edible mushroom Pleurotus eous (Berk.) Sacc.", Heliyon Volume 7 Issue 1, 2022

Publisher : Elsevier

Year : 2022

Prebiotic Potential and Value-Added Products Derived from Spirulina laxissima SV001—A Step towards Healthy Living. BioTech 2022, 11, 13

Cite this Research Publication : V Sankarapandian, K Nitharsan, K Parangusadoss, P Gangadaran, P Ramani, BA Venmathi Maran, MP Jogalekar, "Prebiotic Potential and Value-Added Products Derived from Spirulina laxissima SV001—A Step towards Healthy Living. BioTech 2022, 11, 13", 2022

Publisher : s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil-iations.

Year : 2022

Minireview Highlight article

Cite this Research Publication : Prakash Gangadaran, Himabindu Padinjarathil, Shri Hari Subhashri Rajendran, Manasi P Jogalekar, Chae Moon Hong, Baladhandapani Aruchamy, Uma Maheswari Rajendran, Sridharan Gurunagarajan, Anand Krishnan, Prasanna Ramani, Kavimani Subramanian, "Minireview Highlight article", Experimental Biology and Medicine Volume 247 Pages 1330-1334, 2022

Year : 2022

Prebiotic Potential and Value-Added Products Derived from Spirulina laxissima SV001—A Step towards Healthy Living

Cite this Research Publication : Vidya Sankarapandian, Kirubakaran Nitharsan, Kavitha Parangusadoss, Prakash Gangadaran, Prasanna Ramani, Balu Alagar Venmathi Maran, Manasi P Jogalekar, "Prebiotic Potential and Value-Added Products Derived from Spirulina laxissima SV001—A Step towards Healthy Living", BioTech Volume 11 Issue 2 Pages 13, 2022

Publisher : MDPI

Year : 2022

Convalescent serum-derived exosomes: attractive niche as COVID-19 diagnostic tool and vehicle for mRNA delivery

Cite this Research Publication : Anand Krishnan, Prakash Gangadaran, Vivek P Chavda, Manasi P Jogalekar, Ramesh Muthusamy, Disha Valu, Chithravel Vadivalagan, Prasanna Ramani, Alexey Laishevtcev, Naresh Kumar Katari, Byeong-Cheol Ahn, "Convalescent serum-derived exosomes: attractive niche as COVID-19 diagnostic tool and vehicle for mRNA delivery", Experimental Biology and Medicine Volume 247 Issue 14 Pages 1244-1252, 2022

Publisher : SAGE Publications

Year : 2022

COVID-19 and diabetes: What do we know so far?

Cite this Research Publication : Prakash Gangadaran, Himabindu Padinjarathil, Shri Hari Subhashri Rajendran, Manasi P Jogalekar, Chae Moon Hong, Baladhandapani Aruchamy, Uma Maheswari Rajendran, Sridharan Gurunagarajan, Anand Krishnan, Prasanna Ramani, Kavimani Subramanian, "COVID-19 and diabetes: What do we know so far?", Experimental Biology and Medicine Volume 247 Issue 15 Pages 1330-1334, 2022

Publisher : SAGE Publications

Year : 2022

Antioxidant, Anti-Tumour, and Anticoagulant Activities of Polysaccharide from Calocybe indica (APK2)

Cite this Research Publication : Ambika Nataraj, Sudha Govindan, Prasanna Ramani, Krishnamoorthy Akkana Subbaiah, S Sathianarayanan, Baskar Venkidasamy, Muthu Thiruvengadam, Maksim Rebezov, Mohammad Ali Shariati, José M Lorenzo, Mirian Pateiro, "Antioxidant, Anti-Tumour, and Anticoagulant Activities of Polysaccharide from Calocybe indica (APK2)", Antioxidants Volume 11 Issue 9 Pages 1694, 2022

Publisher : MDPI

Year : 2022

Chalcone: A promising bioactive scaffold in medicinal chemistry

Cite this Research Publication : Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn, "Chalcone: A promising bioactive scaffold in medicinal chemistry", Pharmaceuticals Volume 15 Issue 10 Pages 1250, 2022

Publisher : MDPI

Year : 2022

Effects of Carboxymethyl Modification on the Acidic Polysaccharides from Calocybe indica: Physicochemical Properties, Antioxidant, Antitumor and Anticoagulant Activities

Cite this Research Publication : Ambika Nataraj, Sudha Govindan, Archana Rajendran, Prasanna Ramani, Krishnamoorthy Akkana Subbaiah, Paulo ES Munekata, Mirian Pateiro, José M Lorenzo, "Effects of Carboxymethyl Modification on the Acidic Polysaccharides from Calocybe indica: Physicochemical Properties, Antioxidant, Antitumor and Anticoagulant Activities", Antioxidants Volume 12 Issue 1 Pages 105, 2022

Publisher : MDPI

Year : 2021

Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats

Cite this Research Publication : Sudha Govindan, Angu Jayabal, Jayasakthi Shanmugam, Prasanna Ramani, "Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats", Food Science and Human Wellness Volume 10 Issue 4 Pages 523-535, 2021

Publisher : Elsevier

Year : 2021

Investigation of chemical and biological properties of an acidic polysaccharide fraction from Pleurotus eous (Berk.) Sacc.

Cite this Research Publication : Sasikala Gunasekaran, Sudha Govindan, Prasanna Ramani, "Investigation of chemical and biological properties of an acidic polysaccharide fraction from Pleurotus eous (Berk.) Sacc.", Food Bioscience Volume 42 Pages 101209, 2021

Publisher : Elsevier

Year : 2020

Antioxidant and cytotoxic activities of Indian caper (Capparis brevispina DC (Capparaceae)) leaf extracts

Cite this Research Publication : S. Kumar Subramanian and Ramani, P., “Antioxidant and cytotoxic activities of Indian caper (Capparis brevispina DC (Capparaceae)) leaf extracts”, European Journal of Integrative Medicine, vol. 33, p. 101038, 2020.

Publisher : European Journal of Integrative Medicine

Year : 2019

One-pot synthesis of modified 4-aryl-4H-chromenes and their preliminary anti-cancer studies

Cite this Research Publication : Archana D Nair, CK Athira, Priyadharshini Manikandan, Prasanna Ramani, "One-pot synthesis of modified 4-aryl-4H-chromenes and their preliminary anti-cancer studies", J. Indian Chem. Soc Volume 96 Pages 19-22, 2019

Year : 2019

Biological Evaluation of Dipteracanthus Prostratus (Poir) Nees Leaves From Southern India

Cite this Research Publication : Rosemol Jose, EM Akshaya, CF Sowmya, Prasanna Ramani, "Biological Evaluation of Dipteracanthus Prostratus (Poir) Nees Leaves From Southern India", Materials Today: Proceedings Volume 18 Pages 1575-1580, 2019

Publisher : Elsevier

Year : 2018

Synthesis of Peptide Nucleic Acid Monomers via N‐Alkylation of Nosyl‐protected Amino Acids with N‐Boc Bromoethyl Amine

Cite this Research Publication : Sudhakar Reddy Malamgari, Priyadharshini Manikandan, Prasanna Ramani, Vishweshwar Rao Katta, "Synthesis of Peptide Nucleic Acid Monomers via N‐Alkylation of Nosyl‐protected Amino Acids with N‐Boc Bromoethyl Amine", ChemistrySelect Volume 3 Issue 14 Pages 3948-3951, 2018

Year : 2018

Synthesis of luminescent 2,3-diphenylmaleimide-labelled peptide nucleic acid oligomers

Cite this Research Publication : Prasanna Ramani, Silvia Cauteruccio, Emanuela Licandro, Clara Baldoli, "Synthesis of luminescent 2, 3-diphenylmaleimide-labelled peptide nucleic acid oligomers", Tetrahedron Letters Volume 59 Issue 23 Pages 2229-2231, 2018

Publisher : Tetrahedron Letters

Year : 2018

Invitro anti-inflammatory activity of Kleinia Grandiflora leaves

Cite this Research Publication : S Selvakumar, KS Vaishav Raj, S Vignesh, Prasanna Ramani, "Invitro anti-inflammatory activity of Kleinia Grandiflora leaves", Materials Today: Proceedings Volume 5 Issue 8 Pages 16539-16542, 2018

Publisher : Materials Today: Proceedings

Year : 2017

Physico-chemical Studies of Amoxycillin Loaded Sulfonated Polymer

Cite this Research Publication : Sindhu S., ,, Suresh, S., and Ramani, P., “Physico-chemical Studies of Amoxycillin Loaded Sulfonated Polymer”, Materials Today Proceedings , 2017.

Publisher : Materials Today Proceedings

Year : 2016

4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies

Cite this Research Publication : Na Thomas, Dr. Subin Mary Zachariah, and Dr. Prasanna Ramani, “4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies”, Journal of Heterocyclic Chemistry, vol. 53, no. 6, pp. 1778-1782, 2016.

Publisher : HeteroCorporation

Year : 2015

Applications of Fluorescent Makers

Publisher : J. Environ. Nanotechnol

Year : 2013

Design of Novel Drug Molecules for the Treatment of Breast Cancer

Publisher : International Journal of Pharmaceutical Sciences Review and Research

Year : 2008

A new synthetic approach to 7-hydroxynitidine

Cite this Research Publication : Dr. Prasanna Ramani and Fontana, G., “A new synthetic approach to 7-hydroxynitidine”, Tetrahedron Letters, vol. 49, pp. 5262 - 5264, 2008.

Publisher : Tetrahedron Letters

Year : 2007

Ferrocene derivatives supported on poly (N-vinylpyrrolidin-2-one)(PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules

Cite this Research Publication : Clara Baldoli, Claudio Oldani, Emanuela Licandro, Prasanna Ramani, Antonio Valerio, Paolo Ferruti, Luigi Falciola, Patrizia Mussini, "Ferrocene derivatives supported on poly (N-vinylpyrrolidin-2-one)(PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules", Journal of organometallic chemistry Volume 692 Issue 6 Pages 1363-1371, 2007

Publisher : Elsevier

Year : 2007

Synthesis of new water soluble electrochemically active probes for biomolecules

Publisher : 2007.

Year : 2007

Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules

Cite this Research Publication : C. Baldoli, Oldani, C., Licandro, E., Dr. Prasanna Ramani, Valerio, A., Ferruti, P., Falciola, L., and Mussini, P., “Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules”, Journal of Organometallic Chemistry, vol. 692, pp. 1363 - 1371, 2007.

Publisher : Journal of Organometallic Chemistry

Year : 2006

Erratum Erratum to “A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties” [J. Organomet. Chem. 689 (25) (2004) 4791]

Cite this Research Publication : Clara Baldoli, Luigi Falciola, Emanuela Licandro, Stefano Maiorana, Patrizia Mussini, Prasanna Ramani, Clara Rigamonti, Giovanna Zinzalla, "Erratum to “A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties”[J. Organomet. Chem. 689 (25)(2004) 4791]", Journal of Organometallic Chemistry Volume 3 Issue 691 Pages 539, 2006

Year : 2005

Synthesis and electrochemical studies studies of new ferrocene conjugated PNA monomers

Cite this Research Publication : Synthesis and electrochemical studies studies of new ferrocene conjugated PNA monomers / C. Rigamonti, C. Baldoli, E. Licandro, S. Maiorana, S. Dall'Angelo, P. Ramani, D. Resemini, L. Falciola, P.R. Mussini. ((Intervento presentato al convegno ISOC tenutosi a Riccione nel 2005.

Year : 2005

Synthesis of electrochemical and fluorescent probes for peptide nucleic acid (PNA) monomers

Cite this Research Publication : Synthesis of electrochemical and fluorescent probes for peptide nucleic acid (PNA) monomers / P. Ramani, C. Baldoli, E. Licandro, S. Maiorana, C. Rigamonti, C. Oldani, D. Resemini, L. Falciola, P. Mussini, F. Tessore. ((Intervento presentato al convegno ISOC-Riccione 2005 tenutosi a Riccione nel 2005.

Year : 2004

A new ferrocene Conjugated of a tyrosine PNA monomer synthesis and electrochemical properties

Cite this Research Publication : Dr. Prasanna Ramani, Baldoli, C., Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Rigamonti, C., and Zinzalla, G., “A new ferrocene Conjugated of a tyrosine PNA monomer synthesis and electrochemical properties”, Journal of Organometallic Chemistry, 2004.

Publisher : Journal of Organometallic Chemistry

Year : 2004

A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties

Cite this Research Publication : C. Baldoli, Falciola, L., Licandro, E., Maiorana, S., Mussini, P., Dr. Prasanna Ramani, Rigamonti, C., and Zinzalla, G., “A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties”, Journal of Organometallic Chemistry, vol. 689, pp. 4791 - 4802, 2004.

Publisher : Journal of Organometallic Chemistry

Conference Paper

Year : 2018

Polymer-iron tungstate-reduced graphene oxide nanocomposites for microwave absorption

Cite this Research Publication : S. Krishna Muralidharan, Balaji, S., Raj, G., Pravin, P., Kumar, S., Kothurkar, N., Ramani, P., Narayanan, B., and Moorthy, A., “Polymer-iron tungstate-reduced graphene oxide nanocomposites for microwave absorption”, in IOP Conference Series: Materials Science and Engineering (IConAMMA 2018), 2018.

Publisher : IOP Conference Series: Materials Science and Engineering (IConAMMA 2018).

Year : 2018

Synthesis, Antioxidant and Anti-inflammatory Studies of Substituted Chromene – A Preliminary Anti-Cancer study

Cite this Research Publication : cited By 0; Conference of 2016 International Conference on Advanced Materials, SCICON 2016 ; Conference Date: 19 December 2016 Through 21 December 2016; Conference Code:138807

Publisher : Elsevier Ltd

Year : 2018

Phthalimido protected peptide nucleic acid monomer – Synthesis and Characterization

Cite this Research Publication : S. Sivakumar, Ramani, P., and Shilpa, G. S., “Phthalimido protected peptide nucleic acid monomer - Synthesis and Characterization”, in Materials Today: Proceedings, 2018, vol. 5, pp. 16580-16584.

Publisher : Materials Today: Proceedings

Year : 2018

An alternate method to synthesize zeolites for biological applications

Cite this Research Publication : E. R. Pavithra, Arun, M., Swaminathan, R. A., Vishwanath, S. M. M., and Ramani, P., “An alternate method to synthesize zeolites for biological applications”, in Materials Today: Proceedings, 2018, vol. 5, pp. 16461-16465.

Publisher : Materials Today: Proceedings

Year : 2006

Synthesis of new organometallic probes for peptide nucleic acid

Cite this Research Publication : FRANCESCA TESSORE, PRASANNA RAMANI, STEFANO MAIORANA, EMANUELA LICANDRO, ANTONELLA VALERIO, ANNA DAGHETTI, "Synthesis of new organometallic probes for peptide nucleic acid", ISBOMC06: International Symposium on Bioorganometallic Chemistry, 2006

Conference Proceedings

Year : 2019

Ionic liquid mediated synthesis of labelled peptide nucleic acid monomer

Cite this Research Publication : C. K. Athira, Manikandan, P., Dr. Elango K., and Ramani, P., “Ionic liquid mediated synthesis of labelled peptide nucleic acid monomer”, Materials Today: Proceedings, vol. 18. pp. 1735-1739, 2019.

Publisher : Materials Today: Proceedings

Year : 2015

Role of pyrrole in biological systems

Publisher : Recent trends in Medicinal Chemistry

Year : 2015

Applications Of Markers

Publisher : Recent trends in Medicinal Chemistry

Year : 2014

Synthesis of zeolites using polyethylene glycol as binder for biological applications

Publisher : Emerging Trends in Drug Discovery – AICADD 2014

Year : 2014

Synthesis and Analysis of Efficient Drug Delivery System using Sulphonated-Polyetheretherketone

Publisher : 2nd International Conference on Emerging Trends in Chemical and Pharmaceutical Sciences

Book Chapter

Year : 2011

Peptide Nucleic Acids and Markers

Cite this Research Publication : Dr. Prasanna Ramani, “Peptide Nucleic Acids and Markers”, in Academic Publishers, 2011.

Publisher : Academic Publishers

Patents

Year : 2019

Peptide Nucleic Acid monomers and a preparation method

Cite this Research Publication : P. Ramani, “Peptide Nucleic Acid monomers and a preparation method”, 2019.

Year : 2017

Peptide Nucleic Acid monomers and a preparation method thereof

Cite this Research Publication : P. Ramani, “Peptide Nucleic Acid monomers and a preparation method thereof”, U.S. Patent 2017410201932017.

Publisher : Indian Patent application, Filed, Number 201741020193 (2017)

Year : 2017

An Improved Process To Prepare Malonic Acid Derivatives Using Meldrum’s Acid

Cite this Research Publication : P. Ramani and Nair, B., “An Improved Process To Prepare Malonic Acid Derivatives Using Meldrum’s Acid”, U.S. Patent 2017410189172017.

Publisher : Indian Patent application, Filed, Number 201741018917

Year : 2015

Methods and Formulations for Screening and Treatment of Prostate Cancer

Publisher : U.S. Patent

Academic Qualifications
Degree University
Doctoral Degree Research Supervisors: Prof. Stefano Maiorana and Dr.ClaraBaldoli University of Milano, Italy December 2006
Post-graduate Degree Bharathidasan University, Trichy, India August 2000
Professional Appointments
Position Held Institute/University
Associate Professor Department of Sciences, Amrita Vishwa Vidyapeetham July 2015 – Present
Assistant Professor (SG) Department of Sciences, Amrita Vishwa Vidyapeetham March 2009 – June 2015
Research Associate Project Supervisor: Dr. Clara Baldoli University of Milano, Italy. Sep 2006– Feb 2007
Post-Doctoral fellow Project Supervisor: Prof. Carlo Scolastico Centre for bio-molecular Interdisciplinary Studies and Industrial applications (CISI), University of Milan, Italy Feb 2007 –Feb 2009
Research Chemist Orchid Chemicals and Pharmaceuticals Ltd., Chennai I was involved in collaborating with a team of scientists to develop a synthetic process from lab scale to plant scale for many pharmaceutical intermediates including biotin. Sep 2000 – June 2003
Sponsored Projects
Years Funding Agency Title of Project Amount of Grant (INR) Status
2013- 2019 MHRD Center of Excellence in Advanced Materials & Green Technologies 2.5 Crores Completed
2013- 2016 DST-SERB Design, synthesis and characterization of modified peptide nucleic acids having electrochemical/fluorescent markers 26 lakhs Completed
2013- 2016 Heurtey Petrochemical Pvt. Ltd Total Synthesis of modified Berberines – A preliminary anticancer study 1.5 lakhs Completed
2013- 2015 Aventis Pharmaceuticals Pvt. Ltd Synthesis of intermediates for biologically active molecules 0.5 lakhs Completed
Research

The research team at Dhanvanthri Laboratory targets the synthesis of new molecules that can target cancer. Cancer results from the mutation of certain genes that allow the cells to begin their uncontrolled growth. These mutations are inherited or acquired. The group members intend to find a possible solution to a cancer-free world. The following are our Research interests:

Peptide Nucleic Acids
The remarkable binding properties of ‘Peptide Nucleic Acids’ (PNA), the so-called artificial DNAs, have spawned a rapidly expanding new field of research and their applications as therapeutics, DNA diagnostics, tools in biotechnology and much more. PNA is linked to various scientific disciplines, a few including medicinal chemistry, biochemistry, molecular biology, immunology and drug development. Our focus is to improve the solubility and sensitivity to detect complementary natural nucleobases.

Medicinal Chemistry
Endangered Plants
Herbal medicines are assumed to be of great importance in the primary health care of individuals and communities. The World Health Organization has estimated that 80% of the population of developing countries still relies on traditional medicines, mostly plant drugs, for primary health care needs. The high degree of efficacy and safety of herbal medicines make them more acceptable compared to other therapeutic inventions. Plant-based traditional knowledge has become a recognized tool in the search for new sources of drugs and nutraceuticals. Our basic aim is to identify the plants which are on the verge of extinction and find the medicinal value of that plant, which can be used in our day-to-day life.

Anti-Cancer molecules
Alkaloids are a class of naturally occurring organic nitrogen containing compounds. Typical alkaloids are derived from plant sources, they are basic, they contain one or more nitrogen atoms (usually in a heterocyclic ring) and they usually have a marked physiological action on man or other animals. Alkaloids have potent anticancer activity against various cancers. Our intentions are to synthesis some alkaloids and study their biological properties.

Heterocyclic Chemistry
Organic heterocycles, such as substituted chromenes, pyrroles, imidazole and pyridine, are molecules, whose biological activity has been established over time, with extensive research. The group focuses on the application of this statement, by trying to synthesize new molecules, based on one scaffold, and synthesize molecules with other biologically active units, and study their anti-cancer activity.

Sustained Drug Release
Sustained Drug Delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the human system as needed to safely achieve its desired therapeutic effect. This can be attained by maintaining a constant drug concentration for a specific period with the minimum side effects. Most pharmaceutical drugs in the market are encapsulated with gelatin, which is manufactured from the collagen of animal skin or bone. The target in this research is to find an alternative means of encapsulating those drugs for sustained release.

Reviewer – Journals
  • Various journals in MDPI
  • Tetrahedron Letters – Elsevier, awarded as Recognized reviewer
  • Bio-organic and medicinal chemistry – Elsevier,
  • Journal of heterocyclic chemistry – Springer,
  • Journal of Advanced Pharmaceutical Technology and Research – Medknow.
  • The Journal of Organic Chemistry – ACS
Other Academic/Non-Academic Activities
  1. Member, Board of Studies, B.Sc-B.Ed Four-year Integrated Programme, Department of Sciences, Amrita Vishwa Vidyapeetham (2018-till now).
  2. Member, Board of Studies, Chemistry, Department of Sciences, Amrita Vishwa Vidyapeetham (2019-till now)
Honors/Awards/Recognition
  • Member of Research Advisory Committee at JSS school of Pharmacy, Ooty, India (2022)
  • Amrita Innovations and Research Awards – 2021
  • Awarded “Recognized reviewer Status” from Elsevier (2015-2016)
  • Young scientist award received from Department of Science and Technology, India (2013).
  • Recipient of UNESCO grant in collaboration with ICTP to pursue Post-doctoral research at CISI, Univ. of Milan, Italy (Feb 07 – Feb 09).
  • Recipient of grant to work as a “Research Associate” from University of Bari, Italy (Sep06—Feb07)
  • Young researcher award at ―XXX “A. Corbella” Summer School held at Gargnano, Italy (June 2005)
  • Italian Chemical Society (SCI) grant to participate at the ―First Austrian—German— Italian meeting of Organic Chemistry held at Vienna, Austria (April 2005)
  • Member of Italian Chemical Society (SCI) since 2003
  • Awarded financial assistantship in Non-EU category by University of Milan, Italy, for pursuing Doctoral research (2003—2006).
Membership in Professional Bodies
  • Italian Chemical Society (SCI) since 2003
Scientific Lectures Delivered

International

  1. Applications of NMR in biological systems, international distance eduction programme conducted by JSS Ooty, India. (25th June 2021)
  2. Use of Microwave irradiation in Organic synthesis, in ‘Chimica ad altaapplicazione’, CISI Open day, University of Milan, Italy (24th June 2008).
  3. Synthesis of Electrochemical and Fluorescent Probes for Peptide Nucleic Acid (PNA) Monomers, at XXXI summer school, Gargnano, Italy (June 19th—23rd 2006).

National

  1. Introductionabout IPR, Karpagam school of pharmacy, Coimbatore, India (July 2022)
  2. Technology readiness level and research in academic sectors, Karpagam school of pharmacy, Coimbatore, India (Feb 2022)
  3. “Peptide Nucleic Acids and Alternate Form Of Life”, JSS College of Pharmacy, Ooty, India (March 2019).
  4. “Peptides and Artificial Life”, at International Conference on Expanding Horizons in Health, Disease and Pharmaceutics – E(H)²DP 2019, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, India (Feb 2019).
  5. “Biomaterials for life”, Sri Ramakrishna Institute of Technology, Coimbatore, India (Feb 2018).
  6. “Biomaterials and Nucleic acids”, Coimbatore Institute of Technology, Coimbatore, India (Nov 2017)
  7. “Peptide Nucleic Acids and its applications”, Sree Narayana Mangalam College, Maliyankara, Kerala, India (Dec 2015)
  8. “Peptide Nucleic Acids – An Alternate Form of Life”, Nirmala College for Women, Coimbatore, India (Feb 2012)
  9. Seeing the invisible by NMR spectroscopy, School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, India (Mar 2010)
  10. Microwave heating in modern organic synthesis, Avinashilingam University, Coimbatore, India (Mar 2010)
Research Guidance

Doctoral Students

  • “Modified Arecoline Derivatives: Synthesis and Preliminary Anti-Cancer Studies”, Baladhandapani A. Ongoing
  • “Identification, extraction, purification and biological analysis of medicinal plants”, Selvakumar. Ongoing
  • “Synthesis, characterization and biological studies of pyrrole based imidazole scaffolds.”, Bharathi H. G, Ongoing
  • “Development of biocompatible drug embedded polymer membrane for pre-clinical model”, Himabindu P. Ongoing
  • “Fluorescently labelled Peptide Nucleic acids for DNA recognition” Shashikumar. Ongoing
  • “Chalcones and bio-applications” Gayathri Rajendran (Ongoing)
  • “Synthesis of Fluorescent sensors for the detection of various gas” Archana Rajendran (Ongoing)
Collaborations

Within Amrita

  1. Department of Chemical Engineering and Material Sciences (Coimbatore campus)
  2. School of Pharmacy (Kochi Campus)

Outside Amrita

  • Dr. Camelo Drago, Consiglio Nazionale delleRicerche (CNR) – Catania, Italy.
  • Vera Salus RicercaSrl, Catania, Italy
  • Dr. Sandro Dattilo, ICB, CNR, Italy
  • Dr. MirianPaitero Spain
  • Dr. Jose M Lorenzo, Spain
  • Dr. Maheswaran S, IIT- Mumbai, India
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