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Dr. Krishnakumar Menon

Professor, Amrita School of Nanosciences and Molecular Medicine, Kochi

Qualification: Ph.D
krishnakumarmenon@aims.amrita.edu

Bio

Dr. Krishnakumar Menon is a Professor at Amrita Centre for Nanosciences and Molecular Medicine (ACNSMM) and currently heads the Clinical Proteomics and Translational Research Laboratory. Dr. Menon obtained M. Sc. in Biochemistry from Department of Biochemistry, M. S. University of Baroda, India and M. Sc.-Ph. D. on a scholarship equivalent to commonwealth research grant from National Multiple Sclerosis (MS) Society of Australia at Monash-La Trobe University, Australia. He is a recipient of student honor from La Trobe University and the prestigious JSPS fellowship from Japanese government to carry out oligosaccharide changes associated with myelin forming cells at the National Institute for Physiological Sciences, Japan. Subsequently, he was a fellow at the University of Connecticut Health Center, USA, as Research Investigator and Assistant Research Scientist at the University of Iowa hospitals, USA and the Monash Immunology and Stem Cell Laboratories at Monash University, Australia before joining as an Associate Professor at ACNSMM.  Dr. Menon’s main objective is to diagnose MS early and develop therapies for treating MS. In this respect, Dr. Menon developed different techniques for identifying novel biomarkers of diagnostic, prognostic and therapeutic significance in MS. His laboratory is supported by different grants from ICMR, DBT including Indo- Australian and Novartis global research grants. Currently, the lab’s focus is to take their research findings to the clinic for the benefit of patients.

Publications

Journal Article

Year : 2021

Significance of monitoring vascular endothelial growth factor, monocyte chemoattractant protein-1 and Interleukin-8 in diabetic macular edema towards early identification of nonresponders to ranibizumab therapy.

Cite this Research Publication : Tessy Xavier, Swetha Pallikara, Neha Saji, Natasha Radhakrishnan, Krishnakumar N. Menon, and Gopal S. Pillai, “Significance of monitoring vascular endothelial growth factor, monocyte chemoattractant protein-1 and Interleukin-8 in diabetic macular edema towards early identification of nonresponders to ranibizumab therapy.”, Indian Journal of Ophthalmology, vol. 69, no. 6, pp. 1475-1481, 2021.

Publisher : Indian Journal of Ophthalmology

Year : 2020

Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis

Cite this Research Publication : J. J. Vattathara, Prakash, O., Subhramanian, S., Satheeshkumar, M. K., Xavier, T., Anil, M., Pillai, G. S., Anandakuttan, A., Radhakrishnan, S., Sivanarayanan, T. B., Unni, A. K. K., Dr. Gopi Mohan C., and Krishnakumar N. Menon, “Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis”, Scientific Reports, vol. 10, no. 1, p. 3790, 2020.

Publisher : Scientific Reports

Year : 2020

Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis

Cite this Research Publication : J. J. Vattathara, Prakash, O., Subhramanian, S., Satheeshkumar, M. K., Xavier, T., Anil, M., Pillai, G. S., Anandakuttan, A., Radhakrishnan, S., Sivanarayanan, T. B., Unni, A. K. K., Dr. Gopi Mohan C., and Krishnakumar N. Menon, “Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis”, Scientific Reports, vol. 10, no. 1, p. 3790, 2020.

Publisher : Scientific Reports

Year : 2019

Generation of Humanized Single-chain Fragment Variable Immunotherapeutic against EGFR Variant III using Baculovirus Expression System and in vitro validation.

Cite this Research Publication : Serene Xavier, Dr. Gopi Mohan C., Shantikumar V Nair, Krishnakumar N. Menon, and Dr. Lakshmi Sumitra, “Generation of Humanized Single-chain Fragment Variable Immunotherapeutic against EGFR Variant III using Baculovirus Expression System and in vitro validation.”, Int J Biol Macromol, vol. 124, pp. 17-24, 2019.

Publisher : Int J Biol Macromol,

Year : 2019

Nanotechnology Approaches for Enhanced CNS Delivery in Treating Alzheimer’s Disease

Cite this Research Publication : M. A. Arya, Maneesha Kalappurackal, Dr. Sabitha M., Krishnakumar N. Menon, and Sreeja C. Nair, “Nanotechnology Approaches for Enhanced CNS Delivery in Treating Alzheimer's Disease”, Journal of Drug Delivery Science and Technology, vol. 51, pp. 297 - 309, 2019.

Publisher : Journal of Drug Delivery Science and Technology

Year : 2018

Significance of Elevated Prohibitin 1 levels in Multiple Sclerosis Patients Lymphocytes towards the Assessment of Subclinical Disease Activity and its role in the Central Nervous System Pathology of Disease.

Cite this Research Publication : M. Kumaran Sa Kumar, Nair, S., Dr. Ullas Mony, Kalingavarman, S., Venkat, R., Sivanarayanan, T. Balakrishn, Unni, A. Kodakara K., Rajeshkannan, R., Anandakuttan, A., Radhakrishnan, S., and Krishnakumar N. Menon, “Significance of Elevated Prohibitin 1 levels in Multiple Sclerosis Patients Lymphocytes towards the Assessment of Subclinical Disease Activity and its role in the Central Nervous System Pathology of Disease.”, International Journal of Biological Macromolecules, vol. 110, pp. 573-581, 2018.

Publisher : International Journal of Biological Macromolecules

Year : 2018

Molecular Analysis of Oncogene Expressions in Different Grades of Gliomas

Cite this Research Publication : Serene Xavier, Karimassery Ramaiyer Sundaram, Lalitha Biswas, Dilip Panikar, Bindhu Mangalath Rajamma, Nair, S., Krishnakumar N. Menon, and Dr. Lakshmi Sumitra, “Molecular Analysis of Oncogene Expressions in Different Grades of Gliomas”, Journal of Integrated OMICS, vol. 8, pp. 66-73, 2018.

Publisher : Journal of Integrated OMICS

Year : 2018

Fibronectin protein expression in renal cell carcinoma in correlation with clinical stage of tumour.

Cite this Research Publication : Sandeep Kondisetty, Krishnakumar N. Menon, and Ginil Kumar Pooleri, “Fibronectin protein expression in renal cell carcinoma in correlation with clinical stage of tumour.”, Biomark Res, vol. 6, p. 23, 2018.

Publisher : Biomark Res

Year : 2018

Expression and Purification of Quinine Dihydro Pteridine Reductase from astrocytes and its significance in the astrocyte pathology

Cite this Research Publication : S. Chandrashekaran, Karthikeyan, S., Balakrishnan, A., Nair, S., Kumar, M. Kumaran Sa, Vattathara, J. Jose, Krishnakumar N. Menon, and Shantikumar V Nair, “Expression and Purification of Quinine Dihydro Pteridine Reductase from Astrocytes and its Significance in the Astrocyte Pathology”, International Journal of Biological Macromolecules, vol. 110, pp. 567-572, 2018.

Publisher : International Journal of Biological Macromolecules

Year : 2018

Exploring the Role of Defective Fibronectin Matrix Assembly in the VHL-Associated CNS Hemangioblastoma.

Cite this Research Publication : N. Vikkath, Ariyannur, P., Krishnakumar N. Menon, Mr, B., and Pillai, A., “Exploring the Role of Defective Fibronectin Matrix Assembly in the VHL-Associated CNS Hemangioblastoma.”, Drug Metab Pers Ther, vol. 33, no. 3, pp. 127-134, 2018.

Publisher : Drug Metab Pers Ther

Year : 2017

Understanding the Adhesion Mechanism of Mucin Binding domain from Lactobacillus fermentum and its Role in Enteropathogen Exclusion.

Cite this Research Publication : M. Chatterjee, Pushkaran, A. Choorakott, Vasudevan, A. Kumar, Krishnakumar N. Menon, Dr. Raja Biswas, and Dr. Gopi Mohan C., “Understanding the Adhesion Mechanism of Mucin Binding domain from Lactobacillus fermentum and its Role in Enteropathogen Exclusion.”, Int J Biol Macromol, vol. 110, pp. 598-607, 2017.

Publisher : Int J Biol Macromol

Year : 2017

Recombinant Expression of Extracellular Domain of Mutant Epidermal Growth Factor Receptor in Prokaryotic and Baculovirus Expression Systems

Cite this Research Publication : S. K. Vettath, Shivashankar, G., Krishnakumar N. Menon, and Dr. Lakshmi Sumitra, “Recombinant Expression of Extracellular Domain of Mutant Epidermal Growth Factor Receptor in Prokaryotic and Baculovirus Expression Systems”, International Journal of Biological Macromolecules, 2017.

Publisher : International Journal of Biological Macromolecules

Year : 2016

Integration of Common Feature Pharmacophore Modeling and in Vitro Study to Identify Potent AChE Inhibitors

Cite this Research Publication : S. Patil, Tyagi, A., Jose., J., Krishnakumar N. Menon, and Dr. Gopi Mohan C., “Integration of Common Feature Pharmacophore Modeling and in Vitro Study to Identify Potent AChE Inhibitors”, Medicinal Chemistry Research, vol. 25, pp. 2965–2975, 2016.

Publisher : Medicinal Chemistry Research.

Year : 2015

Genotype–phenotype analysis of von Hippel–Lindau syndrome in fifteen Indian families

Cite this Research Publication : N. Vikkath, Valiyaveedan, S., Nampoothiri, S., Radhakrishnan, N., Pillai, G. S., Nair, V., Ginil Kumar Pooleri, Mathew, G., Krishnakumar N. Menon, Ariyannur, P. S., and Pillai, A. B., “Genotype–phenotype analysis of von Hippel–Lindau syndrome in fifteen Indian families”, Familial Cancer, vol. 14, pp. 585–594, 2015.

Publisher : Familial Cancer

Year : 2015

Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells

Cite this Research Publication : M. G. Sangeet Nair, Dr. Ullas Mony, Dr. Deepthy Menon, Dr. Manzoor K., Sidharthan, N., Pavithran, K., Shantikumar V Nair, and Krishnakumar N. Menon, “Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells”, International journal of nanomedicine, 2015.

Publisher : International journal of nanomedicine

Year : 2013

Neuroproteomics: Are We Biased in Our Representation of Molecular Targets Associated with Specific Domains? Implications in Biomarker Discovery

Cite this Research Publication : Krishnakumar N. Menon, Haridasan, A., Xavier, T., Kundargi, R., and Nair, S., “Neuroproteomics: Are We Biased in Our Representation of Molecular Targets Associated with Specific Domains? Implications in Biomarker Discovery”, Current Proteomics, vol. 10, pp. 56-66, 2013.

Publisher : Current Proteomics

Year : 2013

Analysis of Gene Mutations among South Indian Patients with Maple Syrup Urine Disease: Identification of Four Novel Mutations

Cite this Research Publication : M. P. Narayanan, Dr. Damodaran Vasudevan, and Krishnakumar N. Menon, “Analysis of Gene Mutations among South Indian Patients with Maple Syrup Urine Disease: Identification of Four Novel Mutations”, Indian Journal of Geo-Marine Sciences, vol. 50, pp. 442-446, 2013.

Publisher : Indian Journal of Geo-Marine Sciences, National Institute of Science Communication and Information Resources (NISCAIR),

Year : 2012

Rationally Designed Aberrant Kinase-Targeted Endogenous Protein Nanomedicine Against Oncogene Mutated/Amplified Refractory Chronic Myeloid Leukemia

Cite this Research Publication : A. P. Retnakumari, Hanumanthu, P. L., Malarvizhi, G. L., Prabhu, R., Sidharthan, N., Thampi, M. V., Dr. Deepthy Menon, Mony, U., Krishnakumar N. Menon, Keechilat, P., Nair, S., and Dr. Manzoor K., “Rationally Designed Aberrant Kinase-Targeted Endogenous Protein Nanomedicine Against Oncogene Mutated/Amplified Refractory Chronic Myeloid Leukemia”, Molecular Pharmaceutics, vol. 9, pp. 3062-3078, 2012.

Publisher : Molecular Pharmaceutics

Year : 2011

A Novel Unbiased Proteomic Approach to Detect the Reactivity of Cerebrospinal Fluid in Neurological Diseases

Cite this Research Publication : Krishnakumar N. Menon, Steer, D. L., Short, M., Petratos, S., Smith, I., and Bernard, C. C. A., “A Novel Unbiased Proteomic Approach to Detect the Reactivity of Cerebrospinal Fluid in Neurological Diseases”, Molecular and Cellular Proteomics, vol. 10, 2011.

Publisher : Molecular and Cellular Proteomics

Year : 2011

Exploitation of Detergent Thermodynamics in the Direct Solubilization of Myelin Membrane Proteins for Two-dimensional Gel Electrophoresis for Proteomic Analysis

Cite this Research Publication : S. Nair, Xavier, T., Kumar, M. K. Satheesh, Saha, S., and Krishnakumar N. Menon, “Exploitation of Detergent Thermodynamics in the Direct Solubilization of Myelin Membrane Proteins for Two-dimensional Gel Electrophoresis for Proteomic Analysis”, Electrophoresis, vol. 32, pp. 3621-3629, 2011.

Publisher : Electrophoresis

Year : 2010

A Simple and Efficient Method for Processing of Cell Lysates for Two-dimensional Gel Electrophoresis

Cite this Research Publication : T. Xavier, ,, Ganesan, T. S., and Krishnakumar N. Menon, “A Simple and Efficient Method for Processing of Cell Lysates for Two-dimensional Gel Electrophoresis”, Electrophoresis, vol. 31, pp. 2429-2435, 2010.

Publisher : Electrophoresis

Year : 2010

Role of Probiotic Lactobacillus Plantarum in Inhibiting the Growth and Adhesion of Enteric and Food Borne Pathogens

Cite this Research Publication : Krishnakumar N. Menon, Varma, P., Dinesh, K. R., and Raja Biswas, “Role of Probiotic Lactobacillus Plantarum in Inhibiting the Growth and Adhesion of Enteric and Food Borne Pathogens”, J. Food Science, vol. 10, pp. 1750-3841, 2010.

Publisher : J. Food Science

Patents

Year : 2019

Differential cerebrospinal fluid reactivity to pfdn5-alpha for detection of b-cell acute lymphoblastic leukemia

Cite this Research Publication : K. Kumar N. . Menon, Xavier, T., and HARIDASAN, A., “Differential cerebrospinal fluid reactivity to pfdn5-alpha for detection of b-cell acute lymphoblastic leukemia”, U.S. Patent 15 / 314 , 4912019.

Publisher : Volume US 10 ,261,086 B2, Number 15 / 314 , 491

Year : 2018

Composition and Method for Treatment of Diseases Associated with Central Nervous System Inflammation

Cite this Research Publication : Krishnakumar N. Menon, .Mohan, G., and V., J. Jose, “Composition and Method for Treatment of Diseases Associated with Central Nervous System Inflammation”, U.S. Patent TEMP/E-1/12295/2018-CHE (Patent Filed)2018.

Publisher : U.S. Patent

Year : 2017

Prognostic Bio-Marker for Multiple Sclerosis and a Subclinical Assessment of Disease Therewith

Cite this Research Publication : Krishnakumar N. Menon, Kumaran, S., and Kuma, S., “Prognostic Bio-Marker for Multiple Sclerosis and a Subclinical Assessment of Disease Therewith ”, U.S. Patent TEMP/E-1/22385/2017-CHE. (Patent Filed)2017.

Publisher : U.S. Patent

Year : 2017

Compositions and Methods for Autoimmune Disease Treatment Inventors

Cite this Research Publication : Bernard, C. C. A., Krishnakumar N. Menon, Sadanandan, P., Payne, N. L., and Shantikumar V Nair, “Compositions and Methods for Autoimmune Disease Treatment Inventors”, U.S. Patent Australian Provisional Patent Application no: 2016903294 (Patent Filed)2017.

Publisher : U.S. Patent Australian Provisional Patent Application

Year : 2014

Differential Cerebrospinal Fluid Reactivity to pfdn5-alpha for Detection of B-cell Acute Lymphoblastic Central Nervous System Leukemia

Cite this Research Publication : Krishnakumar N. Menon, Xavier, T., and HARIDASAN, A., “Differential Cerebrospinal Fluid Reactivity to pfdn5-alpha for Detection of B-cell Acute Lymphoblastic Central Nervous System Leukemia”, U.S. Patent PCT/IB2014/058167 Patent Filed2014.

Publisher : U.S. Patent PCT/IB2014/058167 Patent Filed2014.

Year : 2013

THE ART,METHOD, MANNER, PROCEES OF USE OF DIFFERENTIAL CEREBROSPINAL FLUID REACTIVITY TO PREFOLDIN-5 ALPHA AS A PROGNOSTIC MARKER FOR B CELL ACUTE LYMPHOBLASTIC- CENTRAL NERVOUS SYSTEM LEUKEMIA RELAPSES

Cite this Research Publication : K. Kumar N. Menon, Xavier, T., and Haridasan, A., “THE ART,METHOD, MANNER, PROCEES OF USE OF DIFFERENTIAL CEREBROSPINAL FLUID REACTIVITY TO PREFOLDIN-5 ALPHA AS A PROGNOSTIC MARKER FOR B CELL ACUTE LYMPHOBLASTIC- CENTRAL NERVOUS SYSTEM LEUKEMIA RELAPSES”, U.S. Patent 155/CHE/20132013.

Publisher : Number 155/CHE/2013, India

Journal

Year : 2022

Interactome based identification and validation of prefoldin 5-α for prognosing CNS leukemia in B-ALL patients

Cite this Research Publication : Xavier, T., Vijayachandran, L.S., Chandran, R., Mony, U., Augustine, A., Sidharthan, N., Ganapathy, R., Keechilat, P., Sundaram, K.R., Menon, K.N. Interactome based identification and validation of prefoldin 5-α for prognosing CNS leukemia in B-ALL patients (2022) Scientific Reports, 12,15491.

Year : 2022

Translational Significance of GMF-β Inhibition by Indazole-4-yl-methanol in Enteric Glial Cells for Treating Multiple Sclerosis

Cite this Research Publication : Subhramanian, S., Ariyath, A., Sabhi, R., Xavier, T., Anandakuttan, A., Kannoth, S., Thennavan, A., Sreekumar, K.P., Unni, A.K.K., Mohan, C.G., Menon, K.N. Translational Significance of GMF-β Inhibition by Indazole-4-yl-methanol in Enteric Glial Cells for Treating Multiple Sclerosis (2023) ACS Chemical Neuroscience, 14, 72-86.

Publisher : ACS Publications

Invited Lectures
  1. “Biochemical dissection of myelin-axolemmal complexes” Biochemistry and Molecular biology symposium, University of Connecticut, USA. 2002.
  2. “Mechanisms in Immune mediated demyelination” Department of Neurology, University of Iowa, Iowa, USA. 2007.
  3. “Biochemical Mechanisms in Demyelination” Department of Biochemistry, Karnataka University, Dharwad, Karnataka, India. 2007.
  4. “”Molecular Mechanisms Involved in the Breakdown of Myelin: Implication for Neurodegenerative Diseases”. Raman Imaging Workshop, National Center for Biological Sciences, Bangalore, India. 2007.
  5. “Molecular Mechanisms in Immune-mediated Demyelination”. National Brain Research Center, Gurgaon, New Delhi, India. 2007.
  6. “Role of Immune factors in Breakdown of Myelin” Monash Immunology and Stem cell Laboratories, Monash University, Melbourne, Australia. 2008.
  7. “Biochemistry of Myelinolysis” Neural Information Laboratory, National Institute for Physiological Sciences, Okazaki, Japan. 2008.
  8. ” Biochemistry behind demyelination and its implications” (2012). Amrita Institute of Medical Sciences, Kochi.
  9. “Identification of novel molecules of clinical significance in neurodegenerative disease using far-western clinical proteomics”. Bioquest International conference (2013). India.
  10. “Far-western clinical proteomics to identify molecules of importance in different autoimmune diseases”. (2014). National Symposium on Trends in Biochemical Sciences. M.S. University of Baroda. India.
  11. “Identification of prognostic marker for central nervous system leukemia and its significance in leukemia pathogenesis” (2015). Next Gen NextGen Genomics, Biology, Bioinformatics and Technology (NGBT) conference, 1-3rd October, HICC, Hyderabad, India
  12. Invited speaker in Amrita samyogam conference on integrative Ayurveda, held at Amrita Institute of Medical Sciences, Kochi. 6-7, August 2017.
  13. Invited speaker in Biological application on Nanoparticles held at IIT Chennai in Dec 4 and 5th 2017. 14. Invited speaker in ICRIMS held at Kochi in July 2018.
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