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Dr. Pankaj Kumar Jha

Associate Professor, Amrita Research Center, Amrita Vishwa Vidyapeetham, Faridabad

Bio

Dr. Pankaj Kumar Jha is an accomplished Associate Professor at Amrita Institute of Medical Sciences, specializing in clinical genetics and genomic analysis. His expertise lies in identifying genetic variants associated with rare and complex diseases, and he has led projects focusing on genotype-phenotype correlations and pathophysiological changes at the cellular level. Previously, Dr. Kumar held prominent roles at MedGenome Labs, AIIMS Jodhpur, CSIR-IGIB, NIH (USA), and the Chinese Academy of Sciences. He has a PhD in Biotechnology and has received several fellowships, including from NIH and the Chinese Academy. He has published extensively, with 26 research papers primarily focused on genetics, genomics, and metabolic diseases. Dr. Kumar possesses advanced skills in genomic data analysis, bioinformatics, machine learning, and statistical software, along with hands-on experience in experimental and computational genomics.

Publications

Journal Article

Year : 2022

Landscape of Variability in Chemosensory Genes Associated With Dietary Preferences in Indian Population: Analysis of 1029 Indian Genomes

Cite this Research Publication : P. Prakrithi, Pankaj Jha, Jushta Jaiswal, Disha Sharma, Rahul C. Bhoyar, Abhinav Jain, Mohamed Imran, Vigneshwar Senthilvel, Mohit Kumar Divakar, Anushree Mishra, Jaspal Sabharwal, Vinod Scaria, Sridhar Sivasubbu, Mitali Mukerji, Landscape of variability in chemosensory genes associated with dietary preferences in Indian population: Analysis of 1029 Indian genomes, Front Genet, 2022 Jul 12;13:878134.

Year : 2021

Mutational Spectrum of CAPN3 with Genotype-Phenotype Correlations in Limb Girdle Muscular Dystrophy Type 2A/R1 (LGMD2A/LGMDR1) Patients in India

Cite this Research Publication : Pankaj Pathak, Mehar Chand Sharma, Pankaj Jha, Chitra Sarkar, Mohammed Faruq, Prerana Jha, Vaishali Suri, Rohit Bhatia, Sumit Singh, Sheffali Gulati, Mohammad Husain, Mutational spectrum of CAPN3 with genotype-phenotype correlations in Limb Girdle Muscular Dystrophy Type 2A/R1 (LGMD2A/LGMDR1) patients in India, J Neuromuscul Dis. 2021

Year : 2021

Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity

Cite this Research Publication : Samantha E. Day, Michael Traurig, Pankaj Kumar, Paolo Piaggi, Cigdem Koroglu, Sayuko Kobes, Robert L. Hanson, Clifton Bogardus, Leslie J. Baier, Functional Variants in Cytochrome B5 Type A (CYB5A) are Enriched in Southwest American Indians and Associate with Obesity, Obesity, 2021

Year : 2020

Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians

Cite this Research Publication : Paolo Piaggi, Çiğdem Köroğlu, Anup Nair, Jeff Sutherland, Yunhua Li Muller, Pankaj Kumar, Wen-Chi Hsueh, Sayuko Kobes, Alan Shuldiner, Hye In Kim, Nehal Gosalia, Christopher Van Hout, Marcus Jone, William Knowler, Jonathan Krakoff, Robert Hanson, Clifton Bogardus, Leslie J Baier, Exome sequencing identifies a nonsense variant in DAO associated with reduced energy expenditure in American Indians, J Clin Endocrinol Metab, 2020.

Year : 2019

Identification and functional validation of genetic variants in potential miRNA target sites of established BMI genes

Cite this Research Publication : Pankaj Kumar, Michael Traurig, and Leslie J. Baier, Identification and Functional Validation of Genetic Variants in Potential miRNA Target Sites of Established BMI Genes, Int J Obes (Lond). 2019. 44(5):1191-1195.

Year : 2016

Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND)

Cite this Research Publication : Williams RC, Elston RC, Kumar P, Knowler WC, Abboud HE, Adler S, Bowden DW, Divers J, Freedman B, Igo RP Jr, Ipp E, Iyengar SK, Kimmel PL, Klag MJ, Kohn O, Langefeld CD, Leehey DJ, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Rotter JI, Schelling JR, Sedor JR, Shah VO, Smith MW, Taylor KD, Thameem F, Thornley-Brown D, Winkler CA, Guo X, Zager P, Hanson RL, FIND Research Group. Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND), BMC Genomics, 2016

Year : 2015

Interferon-γ (IFNG) microsatellite repeat and single nucleotide polymorphism haplotypes of IFN-α receptor (IFNAR1) associated with enhanced malaria susceptibility in Indian populations

Cite this Research Publication : Kanchan K, Jha P, Pati SS, Mohanty S, Mishra SK, Sharma SK, Awasthi S, Venkatesh V, Habib S. Interferon-γ (IFNG) microsatellite repeat and single nucleotide polymorphism haplotypes of IFN-α receptor (IFNAR1) associated with enhanced malaria susceptibility in Indian populations, Infect Genet Evol, 2015

Year : 2015

Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity

Cite this Research Publication : Pankaj Jha, Dongsheng Lu, Yuan Yuan, Shuhua Xu, Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity, Mol Genet Genomics, 2015

Year : 2015

Natural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing Data

Cite this Research Publication : Pankaj Jha, Dongsheng Lu, Shuhua Xu, Natural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing Data, Natural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing Data, PLoS One, 2015

Year : 2014

Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins

Cite this Research Publication : Kaurani L, Vishal M, Kumar D, Sharma A, Mehani B, Sharma C, Chakraborty S, Jha P, Ray J, Sen A, Dash D, Ray K, Mukhopadhyay A, Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins, Invest Ophthalmol Vis Sci, 2014

Year : 2014

Extensive copy number variations in admixed Indian population of African ancestry: potential involvement in adaptation

Cite this Research Publication : Narang A, Jha P, Kumar D, Kutum R, Mondal AK; Indian Genome Variation Consortium, Dash D, Mukerji M, Extensive copy number variations in admixed Indian population of African ancestry: potential involvement in adaptation, Genome Biol Evol, 2014

Year : 2013

Comparative study of IDH1 mutations in gliomas by high resolution melting analysis, immunohistochemistry and direct DNA sequencing

Cite this Research Publication : Agarwal S, Sharma MC, Jha P, Pathak P, Suri V, Sarkar C, Chosdol K, Suri A, Kale SS, Mahapatra AK, Jha P. Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing, Neuro Oncol, 2013

Year : 2012

Footprints of genetic susceptibility to pulmonary tuberculosis: cytokine gene variants in north Indians

Cite this Research Publication : Abhimanyu, Bose M, Jha P, Indian Genome Variation Consortium. Footprints of genetic susceptibility to pulmonary tuberculosis: Cytokine gene variants in north Indians, Indian J Med Res., 2012

Year : 2012

Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria

Cite this Research Publication : Jha P, Swapnil Sinha, Kanika Kanchan, Tabish Qidwai, Ankita Narang, Prashant Kumar Singh, Sudhanshu S. Pati, Sanjib Mohanty, Saroj K. Mishra, Surya K. Sharma, Shally Awasthi, Vimala Venkatesh, Sanjeev Jain, Analabha Basu, Shuhua Xu, Indian Genome Variation Consortium, Mitali Mukerji, Saman Habib, Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria, Infect Genet Evol. 2012.

Year : 2011

TP53 polymorphisms in gliomas from Indian patients: Study of codon 72 genotype, rs1642785, rs1800370 and 16 base pair insertion in intron-3

Cite this Research Publication : Jha P, Pathak P, Chosdol K, Suri V, Sharma MC, Kumar G, Singh M, Mahapatra AK, Sarkar C, TP53 polymorphisms in gliomas from Indian patients: Study of codon 72 genotype, rs1642785, rs1800370 and 16 base pair insertion in intron-3, Exp Mol Pathol, 2011

Year : 2011

Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis

Cite this Research Publication : Abhimanyu, Mangangcha IR, Jha P, Arora K, Mukerji M, Banavaliker JN, Consortium IG, Brahmachari V, Bose M,Differential serum cytokine levels are associated with cytokine gene polymorphisms in North Indians with active pulmonary tuberculosis, Infect Genet Evol, 2011

Year : 2011

Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians

Cite this Research Publication : Abhimanyu, Jha P, Jain A, Arora K, Bose M, Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians,Hum Immunol, 2011

Year : 2011

IDH1 mutations in gliomas: first series from a tertiary care centre in India with comprehensive review of literature

Cite this Research Publication : Jha P, Suri V, Sharma V, Singh G, Sharma MC, Pathak P, Chosdol K, Jha P, Suri A, Mahapatra AK, Kale SS, Sarkar C, IDH1 mutations in gliomas: First series from a tertiary care centre in India with comprehensive review of literature, Exp Mol Pathol, 2011

Year : 2011

Recent admixture in an Indian population of African ancestry

Cite this Research Publication : Ankita Narang, Jha P, Vimal Rawat, Arijit Mukhopadhayay, Debasis Dash, Analabha Basu, Mitali Mukerji, Recent admixture in an Indian population of African ancestry, Am. J. Hum. Genet, 2011

Year : 2011

Spectrum of large copy number variations in 26 diverse Indian populations: potential involvement in phenotypic diversity

Cite this Research Publication : Gautam P, Jha P, Kumar D, Tyagi S, Varma B, Dash D, Mukhopadhyay A, Indian Genome Variation Consortium, Mukerji M. Spectrum of large copy number variations in 26 diverse Indian populations: potential involvement in phenotypic diversity, Hum Genet, 2011

Year : 2011

A 54 Mb 11qter duplication and 0.9 Mb 1q44 deletion in a child with laryngomalacia and agenesis of corpus callosum

Cite this Research Publication : Lall M, Thakur S, Puri R, Verma I, Mukerji M, Jha P, A 54 Mb 11qter duplication and 0.9 Mb 1q44 deletion in a child with laryngomalacia and agenesis of corpus callosum, Mol Cytogenet, 2011

Year : 2011

A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family

Cite this Research Publication : Shalini Datta, Abhijit Chowdhury, Malay Ghosh, Kaushik Das, Jha P, Roshan Colah, Mitali Mukerji, Partha P. Majumder, A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family, Annals of Human Genetics, 2011

Year : 2010

EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda

Cite this Research Publication : Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A; Indian Genome Variation Consortium, Prasher B, Mukerji M, EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda, Proc Natl Acad Sci U S A, 2010

Year : 2010

O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment

Cite this Research Publication : Jha P, Suri V, Jain A, Sharma MC, Pathak P, Jha P, Srivastava A, Suri A, Gupta D, Chosdol K, Chattopadhyay P, Sarkar C, O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment. Neurosurgery, 2010

Year : 2009

Mapping human genetic diversity in Asia

Cite this Research Publication : HUGO Pan-Asian SNP Consortium; Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak,Pankaj Kumar Jha, Mapping human genetic diversity in Asia, Science,2009

Year : 2008

Genetic landscape of the people of India: a canvas for disease gene exploration

Cite this Research Publication : Pankaj Kumar Jha, Indian Genome Variation Consortium. Genetic landscape of the people of India: a canvas for disease gene exploration, J Genet, 2008

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