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Dr. Manish Kumar Jeengar

Assistant Professor, Department of Pharmacology, School of Pharmacy, Kochi

Qualification: MS, Ph.D
Research Interest: Cancer Research, Molecular Biology, Nanotechnology, Pharmacological Evaluation of Drug Candidate, Regulatory Toxicology

Bio

Dr. Manish Kumar Jeengar is an Assistant Professor at the Department of Pharmacology, Amrita School of Pharmacy, Kochi, India. He completed his B. Pharm in the year 2009 from Department of Pharmacy, Mohan Lal Sukhadia University (MLSU), Udaipur, Rajasthan. He obtained MS (Pharm.) in Regulatory Toxicology from National Institute of Pharmaceutical Education & Research (NIPER), Mohali in 2011 and Ph.D. in Pharmacology & Toxicology from National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad in 2016.His research training was diverse and highly interdisciplinary. His primary areas of interest are chronicinflammatory and autoimmunedisorders,anticancer drug research, molecular pharmacology and toxicology.

During his postdoctoral research (2016-17) at Linköping University, Sweden he was involved in the pharmacological evaluation of pyrimidine derivatives in DSS induced Colitis and antigen induced arthritis model. He has also worked as a research associate at one of prestigious research institute of India ICMR-National Institute of Virology, (NIV) Pune where he worked on a research project related to delivery of siRNA for gene silencing in Chikungunya virus (in vitro and in vivo)He has published total 29 papers in International Journals [ h-index = 20;i10-index = 22; the number of citations: 1038 in Google scholar (July 2021)].

Publications

Journal Article

Year : 2021

Antiviral Activity of Stearylamine against Chikungunya Virus

Cite this Research Publication : Dr. Manish Kumar Jeengar, Kurakula, M., Patil, P., More, A., Sistla, R., and Parashar, D., “Antiviral Activity of Stearylamine against Chikungunya Virus”, Chemistry and Physics of Lipids, vol. 23, p. 10504, 2021.

Publisher : Chemistry and Physics of Lipids

Year : 2021

In Vitro and in vivo Studies reveal α-Mangostin, a xanthonoid from Garcinia Mangostana

Cite this Research Publication : Dr. Manish Kumar Jeengar, Patil P, Agrawal M, Almelkar S, Alagarasu K, Kumar NV, Mainkar PS, Parashar D, and Cherian S, “In Vitro and in vivo Studies reveal α-Mangostin, a xanthonoid from Garcinia Mangostana”, Virol J, vol. 18, pp. 1-12, 2021.

Publisher : Virol J

Year : 2020

Local Administration of 4-Thiouridine, a Novel Molecule with Potent Anti-Inflammatory Properties, Protects Against Experimental Colitis and Arthritis

Cite this Research Publication : Dr. Manish Kumar Jeengar, Narendra, S. Chenna, Thummuri, D., Magnusson, M., V.G.M. Naidu, and Uppugunduri, S., “Local Administration of 4-Thiouridine, a Novel Molecule with Potent Anti-Inflammatory Properties, Protects Against Experimental Colitis and Arthritis”, International Immunopharmacology, vol. 85, p. 106598, 2020.


Publisher : International Immunopharmacology

Year : 2017

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

Cite this Research Publication : Dr. Manish Kumar Jeengar, Thummuri D, Uppugunduri S, Magnusson M, and Naidu V.G.M, “Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice”, Sci Rep, vol. 7, p. 3924, 2017.

Publisher : Sci Rep

Year : 2017

Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial–mesenchymal transition

Cite this Research Publication : S. Shrivastava, Dr. Manish Kumar Jeengar, Thummuri, D., Koval, A., Katanaev, V. L., Marepally, S., and Naidu, V. G. M., “Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial–mesenchymal transition”, BioFactors, vol. 43, pp. 152-169, 2017.

Publisher : BioFactors

Year : 2016

Emu oil based Nano-emulgel for Topical Delivery of Curcumin

Cite this Research Publication : Dr. Manish Kumar Jeengar, Rompicharla, S. Vishnu Kir, Shrivastava, S., Chella, N., Shastri, N. R., V.G.M. Naidu, and Sistla, R., “Emu oil based Nano-emulgel for Topical Delivery of Curcumin”, International Journal of Pharmaceutics, vol. 506, pp. 222-236, 2016.

Publisher : International Journal of Pharmaceutics

Year : 2016

Lactoferrin Bioconjugated solid Lipid Nanoparticles: A New Drug Delivery System for Potential Brain Targeting

Cite this Research Publication : I. Singh, Swami, R., Pooja, D., Dr. Manish Kumar Jeengar, Khan, W., and Sistla, R., “Lactoferrin Bioconjugated solid Lipid Nanoparticles: A New Drug Delivery System for Potential Brain Targeting”, Journal of Drug Targeting, vol. 24, pp. 212-223, 2016.

Publisher : Taylor & Francis

Year : 2016

Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil

Cite this Research Publication : Dr. Manish Kumar Jeengar, Shrivastava, S., S. Veeravalli, C. Mouli, V.G.M. Naidu, and Sistla, R., “Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil”, Nutrition, vol. 32, pp. 955-964, 2016.

Publisher : Nutrition

Year : 2016

Synthesis and Biological Evaluation of Oxindole linked indolyl-pyrimidine Derivatives as Potential Cytotoxic Agents

Cite this Research Publication : S. Kumar Prajapti, Nagarsenkar, A., Guggilapu, S. Devi, Gupta, K. Kumar, Allakonda, L., Dr. Manish Kumar Jeengar, V.G.M. Naidu, and Babu, B. Nagendra, “Synthesis and Biological Evaluation of Oxindole linked indolyl-pyrimidine Derivatives as Potential Cytotoxic Agents”, Bioorganic & Medicinal Chemistry Letters, vol. 26, pp. 3024-3028, 2016.

Publisher : Bioorganic & Medicinal Chemistry Letters

Year : 2015

H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation

Cite this Research Publication : P. Sharma, Senwar, K. Ram, Dr. Manish Kumar Jeengar, T. Reddy, S., V.G.M. Naidu, Kamal, A., and Shankaraiah, N., “H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation”, European Journal of Medicinal Chemistry, vol. 104, pp. 11-24, 2015.

Publisher : European Journal of Medicinal Chemistry

Year : 2015

p-Hydroxy Benzoic Acid-conjugated Dendrimer Nanotherapeutics as Potential Carriers for Targeted Drug Delivery to Brain: An in Vitro and in vivo Evaluation

Cite this Research Publication : Dr. Manish Kumar Jeengar, Swami R, Kulhari H, Singh I, Khan W, and Sistla R, “p-Hydroxy Benzoic Acid-conjugated Dendrimer Nanotherapeutics as Potential Carriers for Targeted Drug Delivery to Brain: An in Vitro and in vivo Evaluation”, J Nanoparticle Res, vol. 17, pp. 1-11, 2015.

Publisher : J Nanoparticle Res

Year : 2015

Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling

Cite this Research Publication : D. Thummuri, Dr. Manish Kumar Jeengar, Shrivastava, S., Nemani, H., Ramavat, R. Naik, Chaudhari, P., and V.G.M. Naidu, “Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling”, Pharmacological Research, vol. 99, pp. 63-73, 2015.

Publisher : Pharmacological Research

Year : 2015

Anticancer effect of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways

Cite this Research Publication : S. Shrivastava, Dr. Manish Kumar Jeengar, V. Reddy, S., G. Reddy, B., and V.G.M. Naidu, “Anticancer effect of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways”, Experimental and Molecular Pathology, vol. 98, pp. 313-327, 2015.

Publisher : Experimental and Molecular Pathology

Year : 2015

Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting

Cite this Research Publication : R. Swami, Singh, I., Dr. Manish Kumar Jeengar, V.G.M. Naidu, Khan, W., and Sistla, R., “Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting”, International Journal of Pharmaceutics, vol. 486, pp. 287-296, 2015.

Publisher : International Journal of Pharmaceutics

Patents

Year : 2018

Dry Emulsifying Composition Comprising Curcuminoid and Emu Oil

Cite this Research Publication : Dr. Manish Kumar Jeengar and NAIDU, “Dry Emulsifying Composition Comprising Curcuminoid and Emu Oil”, U.S. Patent Indian Patent Application No. 201741010074.2018.

Publisher : U.S. Patent Indian Patent

Education
  • 2011-2016 PhD in Pharmacology & Toxicology
    Laboratory for Molecular Pharmacology, Dept. of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India
    Title: “Evaluation of Emu oil in Combination with Curcumin as a Therapeutic Intervention forChronic Inflammatory Disorders” Under the supervision of Dr. Sistla Ramakrishna, Dr. VGM Naidu
  • 2009-2011 M.S. (Pharm.) in Regulatory Toxicology
    Laboratory of Epigenetics and Diseases, Department of Pharmacology & Toxicology, NIPER-Mohali, (Punjab), India.
    Title: “Pulmonary toxicity studies of inhaled zinc oxide nanoparticles in male SD rats exposed through directed flow nose only exposure system” Under the supervision Prof. K. B. Tikoo
Areas of Interest
  • Inflammation& Immunology (Preclinical research on IBD, Arthritis, Psoriasis)
  • Cancer Research
  • Pharmacological evaluation of drug candidate
  • Molecular biology
  • Nanotechnology
  • Regulatory Toxicology
Awards and Fellowships
  1. International travel award from DST (ITS/1224/2015) to attend 1st Nature Immunology- Cellular & Molecular Immunology Joint Conference, Hefei, China, June, 2015.
  2. NIPER Fellowship for PhD in Pharmacology & Toxicology by Department if Chemical and fertilizers, Govt. Of India, New Delhi (2011-2015)
  3. NIPER Fellowship for MS (Pharm.) by Department of Chemical and fertilizers, Govt. Of India, New Delhi (2011-2015)

Editorial Board Member

Journal CPQ Cancer

Presentations in National and International Conferences
No. Title Year and Venue
1. Rectal Administration of Uridine Alleviates Experimental Colitis in Male C57BL/6 Mice Oct. 2016 – KiiM (Karolinska Institute Inflammation and Immunology network) retreat – 2016, organized by SWIMM, Swedish Society for Immunology, Stockholm, Sweden.
2. Ameliorative effect of carnosic acid on adjuvant induced arthritis via inhibition of microsmal prostaglandin E2 synthase-1 (mPGE2S-1) Dec. 2015 – Tata Institute of Fundamental Research, Centre for Interdisciplinary Sciences, Hyderabad, India, Dec. 2015.
3. Emu Oil based nano-gel for topical delivery of curcumin to Treat adjuvant induced arthritis model and its Mechanistic evaluation June, 2015 – 1st Nature Immunology – Cellular & Molecular Immunology Joint Conference, Hefei, China.
4. Synergistic effect of emu oil-curcumin combination in ameliorating freund’s complete adjuvant induced arthritis in male SD rats 2013 – 46th Annual Conference of the Indian Pharmacological Society IPSCON-Bangalore.
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