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Dr. Binulal Nelson Sathy

Assistant Professor, Amrita Centre for Nanosciences and Molecular Medicine, Kochi

Qualification: Ph.D
binulalns@aims.amrita.edu

Bio Publications
Bio

Ph. D. in Bioengineering (2013) from Amrita Vishwa Vidyapeetham. Experience as Research Assistant at the Institute of Biomedical Sciences, Taiwan, Taipei, as Visiting Scholar at Mikos Lab, Department of Bioengineering, Rice University, USA, as post-doctoral fellow at ACNSMM, Amrita Vishwa Vidyapeetham, and as Postdoctoral Fellow at the Centre for Bioengineering, Trinity College, Dublin, Ireland. Joined Amrita in 2017, as faculty, to pursue research in the area of bioengineering and regenerative medicine. Has over 20 peer-reviewed research publications and two book chapters to his credit. Research interest is in understanding the fundamentals of immunomodulatory and regenerative properties in adult stem cells and bioengineered matrices, for functional tissue regeneration, and is also focussed on the translational aspects of stem cell products and cell-derived matrices for regenerative medicine.

 

Publications

Journal

Year : 2023

Human Adipose-Derived Mesenchymal Stem Cell-Secreted Extracellular Matrix Coating on a Woven Nanotextile Vascular Patch for Improved Endothelial Cell Response

Cite this Research Publication : Gopal, K., Nandakumar, N., Reshmi, C.R., Babu, R., Nair, S. V., Sathy, B.N., Menon, D. Human Adipose-Derived Mesenchymal Stem Cell-Secreted Extracellular Matrix Coating on a Woven Nanotextile Vascular Patch for Improved Endothelial Cell Response (2023) ACS Applied Bio Materials, 6, 3143–3152.

Publisher : ACS Publications

Year : 2023

Development and characterisation of suitably bioengineered microfibrillar matrix-based 3D prostate cancer model for in vitro drug testing

Cite this Research Publication : Thilakan, A.T., Nandakumar, N., Balakrishnan, A.R., Pooleri, G. K., Nair, S.V., Sathy, B.N. Development and characterisation of suitably bioengineered microfibrillar matrix-based 3D prostate cancer model for in vitro drug testing (2023) Biomedical Materials, 18, 065016.

Publisher : IOP Publishing

Year : 2022

Soft hydrogel environments that facilitate cell spreading and aggregation preferentially support chondrogenesis of adult stem cells

Cite this Research Publication : Aprile, P., Whelan, I.T., Sathy, B.N., Carroll, S.F., Kelly, D.J. Soft Hydrogel Environments that Facilitate Cell Spreading and Aggregation Preferentially Support Chondrogenesis of Adult Stem Cells (2022) Macromolecular Bioscience, 22, 2100365.

Publisher : Wiley Online Library

Year : 2022

Bioengineered 3D microfibrous-matrix modulates osteopontin release from MSCs and facilitates the expansion of hematopoietic stem cells

Cite this Research Publication : Nandakumar, N., Mohan, M., Thilakan, A.T., Hridhya K Sidharthan, K. H., Janarthanan, R., Sharma, D., Nair, S.V., Sathy, B.N. Bioengineered 3D Microfibrous-matrix Modulates Osteopontin Release from MSCs and Facilitates the Expansion of Hematopoietic Stem Cells (2022) Biotechnology and Bioengineering, 119, 2964-2978.

Publisher : Wiley Online Library

Year : 2022

Nanofibrous Facemasks with Curcumin for Improved Bacterial/Particulate Filtration and Biocidal Activity

Cite this Research Publication : Chandran R. R., Salim, A., Babu, R., Pal, S., Biswas, R., Nelson, S. B., Nair, S.V., Menon, D. Nanofibrous Facemasks with Curcumin for Improved Bacterial/Particulate Filtration and Biocidal Activity (2022) ACS Applied Polymer Materials, 4, 4839-4849.

Publisher : ACS Publications

Journal Article

Year : 2021

Design, Development and Evaluation of an Interwoven Electrospun Nanotextile Vascular Patch

Cite this Research Publication : Rosebin Babu, Reshmi C. R., Joseph, J., Binulal Nelson Sathy, Shantikumar V Nair, Dr. Praveen Varma, and Dr. Deepthy Menon, “Design, Development, and Evaluation of an Interwoven Electrospun Nanotextile Vascular Patch”, Macromolecular Materials and Engineering (Article in Press), p. 2100359, 2021.

Publisher : Macromolecular Materials and Engineering

Year : 2020

Spatial Presentation of Tissue-Specific Extracellular Matrix Components along Electrospun Scaffolds for Tissue Engineering the Bone-Ligament Interface.

Cite this Research Publication : D. Olvera, Binulal Nelson Sathy, and Kelly, D. J., “Spatial Presentation of Tissue-Specific Extracellular Matrix Components along Electrospun Scaffolds for Tissue Engineering the Bone-Ligament Interface.”, ACS Biomater Sci Eng, vol. 6, no. 9, pp. 5145-5161, 2020.

Publisher : ACS Biomater Sci Eng,

Year : 2019

Electrospinning of Highly Porous yet Mechanically Functional Microfibrillar Scaffolds at the Human Scale for Ligament and Tendon Tissue Engineering

Cite this Research Publication : D. Olvera, Schipani, R., Binulal Nelson Sathy, and Kelly, D. J., “Electrospinning of Highly Porous yet Mechanically Functional Microfibrillar Scaffolds at the Human Scale for Ligament and Tendon Tissue Engineering”, Biomedical Materials , vol. 14, no. 3, p. 035016, 2019.

Publisher : Biomedical Materials

Year : 2019

Hypoxia Mimicking Hydrogels to Regulate the Fate of Transplanted Stem Cells

Cite this Research Publication : Binulal Nelson Sathy, Daly, A., Gonzalez-Fernandez, T., Olvera, D., Cunniffe, G., McCarthy, H. O., Dunne, N., Jeon, O., Alsberg, E., Donahue, T. L. Haut, and Kelly, D. J., “Hypoxia Mimicking Hydrogels to Regulate the Fate of Transplanted Stem Cells”, Acta Biomater, vol. 88, pp. 314-324, 2019.

Publisher : Acta Biomater,

Year : 2018

Engineering Large Cartilage Tissues using Dynamic Bioreactor Culture at Defined Oxygen Conditions

Cite this Research Publication : Binulal Nelson Sathy, Daly, A. C., and Kelly, D. J., “Engineering Large Cartilage Tissues using Dynamic Bioreactor Culture at Defined Oxygen Conditions”, Journal of Tissue Engineering , vol. 9, 2018.

Publisher : Journal of Tissue Engineering .

Year : 2017

Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering.

Cite this Research Publication : G. M. Cunniffe, Gonzalez-Fernandez, T., Daly, A., Binulal Nelson Sathy, Jeon, O., Alsberg, E., and Kelly, D. J., “ Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering.”, Tissue Eng Part A, vol. 23, no. 17-18, pp. 891-900, 2017.

Publisher : Tissue Eng Part A

Year : 2017

Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules.

Cite this Research Publication : S. Pentlavalli, Chambers, P., Binulal Nelson Sathy, O'Doherty, M., Chalanqui, M., Kelly, D. J., Haut-Donahue, T., McCarthy, H. O., and Dunne, N. J., “Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules.”, Macromol Biosci, vol. 17, no. 11, 2017.

Publisher : Macromol Biosci

Year : 2017

Mesenchymal Stem Cell Fate Following Non-viral Gene Transfection Strongly Depends on the Choice of Delivery Vector

Cite this Research Publication : T. Gonzalez-Fernandez, Sathy, B. N., Hobbs, C., Cunniffe, G. M., McCarthy, H. O., Dunne, N. J., Nicolosi, V., O'Brien, F. J., and Kelly, D. J., “Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector.”, Acta Biomater, vol. 55, pp. 226-238, 2017.

Publisher : Acta Biomaterialia, Acta Materialia Inc

Year : 2015

Bone Tissue Engineering with Multilayered Scaffolds—Part II: Combining Vascularization with Bone Formation in Critical-Sized Bone Defect

Cite this Research Publication : Binulal Nelson Sathy, Watson, B. M., Kinard, L. A., Spicer, P. P., Dahlin, R. L., Mikos, A. G., and Shantikumar V Nair, “Bone Tissue Engineering with Multilayered Scaffolds—Part II: Combining Vascularization with Bone Formation in Critical-Sized Bone Defect”, Tissue Engineering Part A, vol. 21, pp. 2495-2503, 2015.

Publisher : Tissue Engineering Part A

Year : 2015

Bone Tissue Engineering with Multilayered Scaffolds-Part I: An Approach for Vascularizing Engineered Constructs In Vivo.

Cite this Research Publication : Binulal Nelson Sathy, Dr. Ullas Mony, Dr. Deepthy Menon, VK, B., AG, M., and Shantikumar V Nair, “Bone Tissue Engineering with Multilayered Scaffolds-Part I: An Approach for Vascularizing Engineered Constructs In Vivo.”, Tissue Eng Part A., pp. 19-20, 2015.

Publisher : Tissue Eng Part A.

Year : 2012

Gelatin nanoparticles loaded poly(€-caprolactone) nanofibrous semi-synthetic scaffolds for bone tissue engineering

Cite this Research Publication : Binulal Nelson Sathy, Natarajan, A., Dr. Deepthy Menon, Bhaskaran, V. K., Dr. Ullas Mony, and Shantikumar V Nair, “Gelatin nanoparticles loaded poly(€-caprolactone) nanofibrous semi-synthetic scaffolds for bone tissue engineering”, Biomedical Materials (Bristol), vol. 7, 2012.

Publisher : Biomedical Materials (Bristol)

Year : 2010

Folate Targeted Polymeric ‘green’ Nanotherapy for Cancer

Cite this Research Publication : S. Narayanan, Binulal Nelson Sathy, Dr. Ullas Mony, Manzoor, K., Shantikumar V Nair, and Dr. Deepthy Menon, “Folate Targeted Polymeric 'green' Nanotherapy for Cancer”, Nanotechnology, vol. 21, 2010.

Publisher : Nanotechnology

Year : 2009

Atomic Force Microscopic Study of Folate Receptors in Live Cells with Functionalized Tips

Cite this Research Publication : Girish C. M., Binulal Nelson Sathy, Anitha, V. C., Nair, S., Dr. Ullas Mony, and Prasanth, R., “Atomic Force Microscopic Study of Folate Receptors in Live Cells with Functionalized Tips”, Applied Physics Letters, vol. 95, 2009.

Publisher : Applied Physics Letters

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