Back close

Dr. Bhargab Kalita

Assistant Professor , Amrita Research Center, Amrita Vishwa Vidyapeetham, Faridabad

Qualification: MSc, Ph.D
bhargabk@acnsmm.aims.amrita.edu

Bio

Dr. Bhargab Kalita is an Assistant Professor at the Amrita Research Centre Faridabad, Amrita Vishwa Vidyapeetham. Dr. Kalita obtained his M.Sc. in Biotechnology (2013) from St. Anthony’s College under the North-Eastern Hill University, Shillong and Ph.D. in Molecular Biology and Biotechnology (2019) from Tezpur University, Assam. His Ph.D. thesis revealed intriguing variation in snake venom proteome composition due to disparities in geographic locations and its subsequent impact on antivenom therapy. Subsequently, he joined as a DBT-Research Associate at the Proteomics Lab of National Centre for Cell Science, Pune. His postdoctoral work was focussed on unveiling the mechanistic insights of oncogenic F-box proteins in cancer and difference in proteomic signatures in haematological malignancies. His current research interests include cancer biology and development of biotherapeutics for cancer therapy from various natural and synthetic sources. His laboratory focuses on development of cancer biotherapeutics and its viable production using different cellular expression systems. In addition, his lab is exploring the diverse molecular and biochemical changes in cancer cells in response to biotherapeutics so as to better understand the efficacy of these molecules in restraining cancer growth.

Publications

Journal Article

Year : 2024

The prowess of metabolomics in cancer research: current trends, challenges and future perspectives

Cite this Research Publication : Khushman Taunk, Saikiran Jajula, Praneeta Pradip Bhavsar, Mahima Choudhari, Sadanand Bhanuse, Anup Tamhankar, Tufan Naiya, Bhargab Kalita, Srikanth Rapole, The prowess of metabolomics in cancer research: current trends, challenges and future perspectives. Molecular and Cellular Biochemistry, pp.1-28, 2024.

Publisher : Springer

Year : 2024

Integrative proteome analysis of bone marrow interstitial fluid and serum reveals candidate signature for acute myeloid leukemia

Cite this Research Publication : Jajula S, Naik V, Kalita B, Yanamandra U, Sharma S, Chatterjee T, Bhanuse S, Bhavsar P.P, Taunk K, Rapole S, Integrative proteome analysis of bone marrow interstitial fluid and serum reveals candidate signature for acute myeloid leukemia, Journal of Proteomics, p.105224, 2024.

Publisher : Elsevier

Year : 2024

Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of Indian Big Four and Naja kaouthia snake venoms

Cite this Research Publication : Chanda A, Salvi N.C, Shelke P.V, Kalita B, Patra A, Puzari U, Khadilkar M.V, Mukherjee A.K, Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of Indian Big Four and Naja kaouthia snake venoms, Toxicon: X,2024

Publisher : Elsevier

Year : 2023

A retrospective analysis of epidemiology, clinical features of envenomation, and in-patient management of snakebites in a model secondary hospital of Assam, North-east India

Cite this Research Publication : Kakati, H., Giri, S., Patra, A., Taye, S.J., Agarwalla, D., Baruah, H., Choudhary, G., Kalita, B. and Mukherjee, A.K., A retrospective analysis of epidemiology, clinical features of envenomation, and in-patient management of snakebites in a model secondary hospital of Assam, North-east India, Toxicon, p.107175,2023.

Year : 2023

Ubiquitination in Cancer Metastasis: Emerging Functions, Underlying Mechanisms, and Clinical Implications

Cite this Research Publication : Barik G.K, Sahay O, Islam S, Ghate N.B, Kalita B, Alam A, Ubiquitination in Cancer Metastasis: Emerging Functions, Underlying Mechanisms, and Clinical Implications, Technology in Cancer Research & Treatment, 22, p.15330338231210720, 2023.

Year : 2022

A comparison of two different analytical workflows to determine the venom proteome composition of Naja kaouthia from North-East India and immunological profiling of venom against commercial antivenoms

Cite this Research Publication : Kakati H, Patra A, Kalita B, Chanda A, Rapole S,Mukherjee A.K, A comparison of two different analytical workflows to determine the venom proteome composition of Naja kaouthia from North-East India and immunological profiling of venom against commercial antivenoms, International Journal of Biological Macromolecules, 208, 275-287,2022

Publisher : Elsevier

Year : 2022

Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy

Cite this Research Publication : Kalita B, Utki, Y.N, Mukherjee A.K, Current insights in the mechanisms of cobra venom cytotoxins and their complexes in inducing toxicity: Implications in antivenom therapy, Toxins, 14(12), 839,2022

Year : 2021

From venom to drugs: a review and critical analysis of Indian snake venom toxins envisaged as anticancer drug prototypes

Cite this Research Publication : Kalita B, Saviola A. J, Mukherjee A. K, From venom to drugs: a review and critical analysis of Indian snake venom toxins envisaged as anticancer drug prototypes, Drug Discovery Today, 26(4), 993-1005,2021

Publisher : Elsevier

Year : 2021

Keep your eyes peeled for long noncoding RNAs: Explaining their boundless role in cancer metastasis, drug resistance, and clinical application

Cite this Research Publication : Barik G.K, Sahay O, Behera A, Naik D,Kalita B, Keep your eyes peeled for long noncoding RNAs: Explaining their boundless role in cancer metastasis, drug resistance, and clinical application, Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(2), 188612,2021

Publisher : Elsevier

Year : 2021

Assessment of quality and pre-clinical efficacy of a newly developed polyvalent antivenom against the medically important snakes of Sri Lanka

Cite this Research Publication : Patra A, Kalita B, Khadilkar M.V, Salvi N.C, Shelke P.V, Mukherjee A.K, Assessment of quality and pre-clinical efficacy of a newly developed polyvalent antivenom against the medically important snakes of Sri Lanka, Nature Scientific Reports, 11(1), 1-17,2021

Year : 2021

State-of-the-art review – A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?

Cite this Research Publication : Kalita B, Saviola A.J, Samuel S.P, Mukherjee, A.K, State-of-the-art review-A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?,  International Journal of Biological Macromolecules, 192, 1040-1057, 2021.

Publisher : Elsevier

Year : 2020

Application of mass spectrometry based proteomics to understand diabetes: A special focus on interactomics

Cite this Research Publication : Kalita B, Bano S, Vavachan V. M, Taunk K, Seshadri V,Rapolea S, Application of mass spectrometry based proteomics to understand diabetes: A special focus on interactomics, Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1868(10), 140469, 2020.

Publisher : Elsevier

Year : 2020

The development and clinical applications of proteomics: an Indian perspective

Cite this Research Publication : Taunk K, Kalita B, Kale V, Chanukuppa V, Naiya T, Zingde S. M, Rapole S, The development and clinical applications of proteomics: an Indian perspective, Expert Review of Proteomics, 17(5), 1-19,2020

Year : 2020

Transcriptomic, proteomic, and biochemical analyses reveal a novel neuritogenesis mechanism of Naja naja venom α-elapitoxin post binding to TrkA receptor of rat pheochromocytoma cells

Cite this Research Publication : Islam T, Majumder M, Kalita B, Bhattacharjee A, Mukhopadhyay R, Mukherjee A. K, Transcriptomic, proteomic and biochemical analyses reveal a novel neuritogenesis mechanism of Naja naja venom α‐elapitoxin post binding to TrkA receptor of rat pheochromocytoma cells, Journal of Neurochemistry, 155(6), 612-637,2020

Year : 2019

Proteomic analysis and antivenomics study of Western India Naja naja venom: correlation between venom composition and clinical manifestations of cobra bite in this region

Cite this Research Publication : Chanda A, Kalita B, Patra A, Senevirathne W.D.S.T, Mukherjee A.K, Proteomic analysis and antivenomics study of Western India Naja naja venom: Correlation between venom composition and clinical manifestations of cobra bite in this region, Expert Review of Proteomics, 16(2), 171-184, 2019

Year : 2019

Recent advances in snake venom proteomics research in India: a new horizon to decipher the geographical variation in venom proteome composition and exploration of candidate drug prototypes

Cite this Research Publication : Kalita, B, Mukherjee A. K, Recent advances in snake venom proteomics research in India: a new horizon to decipher the geographical variation in venom proteome composition and exploration of candidate drug prototypes, Journal of Proteins and Proteomics, 10(2), 149-164, 2019

Publisher : Springer

Year : 2019

RGD-independent binding of Russell’s Viper venom Kunitz-type protease inhibitors to platelet GPIIb/IIIa receptor

Cite this Research Publication : Kalita B, Dutta S, Mukherjee A. K, RGD-independent binding of Russell’s Viper venom Kunitz-type protease inhibitors to platelet GPIIb/IIIa receptor, Nature Scientific Reports, 9(1), 8316, 2019.

Year : 2018

Anticoagulant mechanism, pharmacological activity, and assessment of preclinical safety of a novel fibrin(ogen)olytic serine protease from leaves of Leucas indica

Cite this Research Publication : Gogoi D., Arora N., Kalita B., Sarma R., Islam T., Ghosh S. S., Devi R., Mukherjee A. K, Anticoagulant mechanism, pharmacological activity, and assessment of preclinical safety of a novel fibrin(ogen)olytic serine protease from leaves of Leucas indica, Nature Scientific Reports, 8(1), 6210, 2018.

Year : 2018

Assessment of quality, safety, and pre-clinical toxicity of an equine polyvalent anti-snake venom (Pan Africa): Determination of immunological cross-reactivity of antivenom against venom samples of Elapidae and Viperidae snakes of Africa

Cite this Research Publication : Patra, A., Kalita B., Mukherjee A. K, Assessment of quality, safety, and pre-clinical toxicity of an equine polyvalent anti-snake venom (Pan Africa): Determination of immunological cross-reactivity of antivenom against venom samples of Elapidae and Viperidae snakes of Africa, Toxicon, 153, 120-127, 2018.

Publisher : Elsevier

Year : 2018

Proteomics analysis to compare the venom composition between Naja naja and Naja kaouthia from the same geographical location of eastern India: Correlation with pathophysiology of envenomation and immunological cross-reactivity towards commercial polyantivenom

Cite this Research Publication : Chanda A., Patra A., Kalita B.,Mukherjee A. K, Proteomics analysis to compare the venom composition between Naja naja and Naja kaouthia from the same geographical location of eastern India: Correlation with pathophysiology of envenomation and immunological cross-reactivity towards commercial polyantivenom, Expert Review of Proteomics, 15(11), 949-961, 2018

Year : 2018

First report of the characterization of a snake venom apyrase (Ruviapyrase) from Indian Russell’s viper (Daboia russelii) venom

Cite this Research Publication : Kalita B., Patra A., Jahan S.,Mukherjee A. K, First report of the characterization of a snake venom apyrase (Ruviapyrase) from Indian Russell's viper (Daboia russelii) venom, International Journal of Biological Macromolecules, 111, 639-648, 2018.

Publisher : Elsevier

Year : 2018

Quantitative proteomic analysis and antivenom study revealing that neurotoxic phospholipase A2 enzymes, the major toxin class of Russell’s viper venom from southern India, shows the least immuno-recognition and neutralization by commercial polyvalent antivenom

Cite this Research Publication : Kalita B, Singh S, Patra A, Mukherjee A. K, Quantitative proteomic analysis and antivenom study revealing that neurotoxic phospholipase A2 enzymes, the major toxin class of Russell's viper venom from southern India, shows the least immuno-recognition and neutralization by commercial polyvalent antivenom, International Journal of Biological Macromolecules, 118(A), 375-385, 2018.

Publisher : Elsevier

Year : 2018

Proteomic Analysis and Immuno-Profiling of Eastern India Russell’s Viper (Daboia russelii) Venom: Correlation between RVV Composition and Clinical Manifestations Post RV Bite

Cite this Research Publication : Kalita B, Patra A, Das A, Mukherjee A. K, Proteomic analysis and immuno-profiling of eastern India Russell’s viper (Daboia russelii) venom: Correlation between RVV composition and clinical manifestations post RV bite, Journal of Proteome Research, 17(8), 2819-2833, 2018

Year : 2018

Proteomic analysis reveals geographic variation in venom composition of Russell’s Viper in the Indian subcontinent: implications for clinical manifestations post-envenomation and antivenom treatment

Cite this Research Publication : Kalita B, Mackessy S.P,Mukherjee A. K, Proteomic analysis reveals geographic variation in venom composition of Russell’s Viper in the Indian subcontinent: Implications for clinical manifestations post-envenomation and antivenom treatment, Expert Review of Proteomics, 15(10), 837-849, 2018.

Year : 2017

A comparative intracellular proteomic profiling of Pseudomonas aeruginosa strain ASP-53 grown on pyrene or glucose as sole source of carbon and identification of some key enzymes of pyrene biodegradation pathway

Cite this Research Publication : Mukherjee A. K., Bhagowati P., Biswa B. B., Chanda A.,Kalita B, A comparative intracellular proteomic profiling of Pseudomonas aeruginosa strain ASP-53 grown on pyrene or glucose as sole source of carbon and identification of some key enzymes of pyrene biodegradation pathway, Journal of Proteomics, 167, 25-35, 2017.

Publisher : Elsevier

Year : 2017

Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties

Cite this Research Publication : Dutta S., Chanda A., Kalita B., Islam T., Patra A., Mukherjee A. K, Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties, Journal of Proteomics, 156, 29-39, 2017

Publisher : Elsevier

Year : 2017

Proteomics and antivenomics of Echis carinatus carinatus venom: Correlation with pharmacological properties and pathophysiology of envenomation

Cite this Research Publication : Patra A., Kalita B., Chanda A., Mukherjee A. K, Proteomics and antivenomics of Echis carinatus carinatus venom: Correlation with pharmacological properties and pathophysiology of envenomation, Nature Scientific Reports, 7(1), 17119, 2017

Year : 2017

Unraveling the Proteome Composition and Immuno-profiling of Western India Russell’s Viper Venom for In-Depth Understanding of Its Pharmacological Properties, Clinical Manifestations, and Effective Antivenom Treatment

Cite this Research Publication : Kalita B, Patra A, Mukherjee A. K, Unravelling the proteome composition and immuno-profiling of western India Russell’s viper venom for in-depth understanding of its pharmacological properties, clinical manifestations, and effective antivenom treatment, Journal of Proteome Research, 16(2), 583–598, 2017

Year : 2016

Structural and functional characterization of complex formation between two Kunitz-type serine protease inhibitors from Russell’s viper venom

Cite this Research Publication : Mukherjee A.K., Dutta S., Kalita B., Jha D.K., Deb P., Mackessy S. P, Structural and functional characterization of complex formation between two Kunitz-type serine protease inhibitors from Russell’s viper venom, Biochimie, 128, 138-147, 2016.

Publisher : Elsevier

Year : 2016

A proteomic analysis of Pakistan Daboia russelii russelii venom and assessment of potency of Indian polyvalent and monovalent antivenom

Cite this Research Publication : Mukherjee A.K., Kalita B., Mackessy S. P, A proteomics analysis of Pakistan Daboia russelii russelii venom and assessment of potency of Indian polyvalent and monovalent antivenom, Journal of Proteomics, 144, 73-86, 2016.

Publisher : Elsevier

Year : 2014

Two Acidic, Anticoagulant PLA2 Isoenzymes Purified from the Venom of Monocled Cobra Naja kaouthia Exhibit Different Potency to Inhibit Thrombin and Factor Xa via Phospholipids Independent, Non-Enzymatic Mechanism

Cite this Research Publication : Mukherjee A.K., Kalita B., Thakur R, Two acidic, anticoagulant PLA2 isoenzymes purified from the venom of Monocled Cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor Xa via phospholipids independent, non-enzymatic mechanism, PloS One, 9(8), e101334, 2014.

Book Chapter

Year : 2021

Snake envenomation: therapy and challenges in India

Cite this Research Publication : Mukherjee A. K., Kalita B., Dutta S., Patra A., Maiti C. R.,Punde D, Snake envenomation: therapy and challenges in India, Handbook of Venoms and Toxins of Reptiles, 2021.

Admissions Apply Now