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Dr. B. Siva Kumar

Associate Professor, Department of Chemistry, School of Engineering, Bengaluru

Qualification: BSc, MSc, Ph.D
b_sivakumar@blr.amrita.edu
Ph: 9440547264

Bio Publications Professional Appointments Research & Management Experience Major Research Interests Membership in Professional Bodies Certificates, Awards & Recognitions Research Grants Received Keynote Addresses/Invited Talks/Panel Memberships Courses Taught Student Guidance
Bio

Dr. B. Siva Kumar currently serves as Associate Professor at the Department of Chemistry, School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru campus.

Hailing from Ooty, Tamil Nadu, Dr. B. Siva Kumar did his schooling in Chennai and then moved to Sri Sathya Sai Institute of Higher Learning (SSSIHL) in Puttaparthi A.P., completing his B. Sc, M. Sc and Ph. D in Chemistry. He received Ph.D. in Organic Chemistry of Natural Products from SSSIHL in the year 2001 and served in various capacities as teaching and research faculty close to 20 years, before resigning as Assoc. Head of the Department and presently working as Associate Professor in Amrita Vishwa Vidyapeetham (Deemed to be University), Bengaluru campus. As a distinguished professor of chemistry, he has gained a deep knowledge and experience in translational research, developing products or procedures that will help individuals and society at large. His thrust area of research is to focus on work related to Materials, Medicine and Modelling. The main objective is to bridge the gap between a) Medical doctors, Scientist and start-up companies to make multi-functional biomaterials; b) Artificial Intelligence (AI) and experimental chemistry through computational science and drug design; and c) Environmental scientist and analytical chemists for renewable energy design.

He has specialized in the modern analytical and spectroscopic techniques used for the characterizations and applications of organic molecules and biomaterials. He has contributed to the world of science by publishing many peer-reviewed journal papers and a book chapter during the pandemic related to understanding SARS-CoV-2—host cell interactions and pathways.

His present research work is on synthesis of biomaterials with a special focus on hydroxy apatite bone composites for bone healing and proliferation applications. Together with polymer blends for drug delivery and computational material science.

His other interests include music and meditation which gives me a balanced approach in life towards progressing in science and spirituality.

Education

  • 2001 : Ph. D.
    Sri Sathya Sai Institute of Higher Learning
  • 1996 : M. Sc.
    Sri Sathya Sai Institute of Higher Learning
  • 1994 : B.Sc. (Hons) Chemistry
    Sri Sathya Sai Institute of Higher Learning
Publications

Journal Article

Year : 2023

Modified Layered Double Hydroxide – PEG Magneto-Sensitive Hydrogels with Suitable Ligno-Alginate Green Polymer Composite for Prolonged Drug Delivery Applications

Cite this Research Publication : Siva Kumar. (2023) Modified Layered Double Hydroxide – PEG Magneto-Sensitive Hydrogels with Suitable Ligno-Alginate Green Polymer Composite for Prolonged Drug Delivery Applications. Engineered Science, 2023, 24, 914.

Publisher : Engineered Science

Year : 2023

Fabricating Transdermal Film Formulations of Montelukast Sodium with Improved Chemical Stability and Extended Drug Release

Cite this Research Publication : Giridhar Reddy, Siva Kumar., Fabricating Transdermal Film Formulations of Montelukast Sodium with Improved Chemical Stability and Extended Drug Release. Heliyon, 2023; 9(3): e14469.

Publisher : Heliyon

Year : 2022

Probing into the potential features of sodium calcium silicate (Na2Ca2Si3O9) synthesized by the solid-state route

Cite this Research Publication : Siva Kumar et.al (2022). Probing into the potential features of sodium calcium silicate (Na2Ca2Si3O9) synthesized by the solid-state route. Physica Scripta, 97, 085001

Year : 2022

Plant Biomass Derived Multidimensional Nanostructured Materials: A Green Alternative for Energy Storage

Cite this Research Publication : Sai Praneeth Thota, Partha Pratim Bag, Praveen Venkata Vadlani and Siva Kumar Belliraj*. Plant Biomass Derived Multidimensional Nanostructured Materials: A Green Alternative for Energy Storage. Eng. Sci., 2022, 18, 31–58. (https://dx.doi.org/10.30919/es8d664)

Publisher : Engineered Science Publisher

Year : 2021

Exploring the unexpected formation of spirobibenzopyrans and benzopyrylium salts and effect of Lewis acids on the Claisen-Schmidt reaction

Cite this Research Publication : Siva Kumar et.al (2021). Exploring the unexpected formation of spirobibenzopyrans and benzopyrylium salts and effect of Lewis acids on the Claisen-Schmidt reaction. Journal of Molecular structure, 1240, 130598.

Publisher : Elsevier

Year : 2020

Diarylidenecyclopentanone derivatives as potent anti-inflammatory and anticancer agents

Cite this Research Publication : Tamang, Nitesh & Ramamoorthy, Gayathri & Joshi, Mayank & Choudury, Angshuman & Belliraj, Siva Kumar & Golakoti, Nageswara & Doble, Mukesh. (2020). Diarylidenecyclopentanone derivatives as potent anti-inflammatory and anticancer agents. Medicinal Chemistry Research. 29. 10.1007/s00044-020-02578-5.

Publisher : Medicinal Chemistry Research

Year : 2020

Zirconium-Cerium and Zirconium–Lanthanum complexed polyvinyl alcohol films for efficient fluoride removal from aqueous solution

Cite this Research Publication : Kiran M, Sai & Bhandari, Rajni & Nehra, Anita & Manohar, Sai & Belliraj, Siva Kumar. (2020). Zirconium–Cerium and Zirconium–Lanthanum complexed polyvinyl alcohol films for efficient fluoride removal from aqueous solution. Journal of Dispersion Science and Technology. 1-16. 10.1080/01932691.2020.1774386.

Publisher : Journal of Dispersion Science and Technology

Year : 2019

An in silico design of bioavailability for kinase inhibitors evaluating the mechanistic rationale in the CYP metabolism of erlotinib

Cite this Research Publication : Chelli SM, Gupta P, Belliraj SK. An in silico design of bioavailability for kinase inhibitors evaluating the mechanistic rationale in the CYP metabolism of erlotinib. J Mol Model. 2019 Feb 14;25(3):65. doi: 10.1007/s00894-018-3917-z. PMID: 30762124.

Publisher : J Mol Model.

Year : 2019

Novel Lead-free biocompatible piezoelectric Hydroxyapatite (HA)–BCZT (Ba0. 85Ca0. 15Zr0. 1Ti0. 9O3) nanocrystal composites for bone regeneration.

Cite this Research Publication : Manohar, Sai & Belliraj, Siva Kumar & Sadhu, Sai Prashanth & Srimadh Bhagavatham, Sai Krishna & Muthukumar, Sai & Venketesh, S. & Varma, Kbr. (2019). Novel Lead-free biocompatible piezoelectric Hydroxyapatite (HA) – BCZT (Ba0.85Ca0.15Zr0.1Ti0.9O3) nanocrystal composites for bone regeneration. Nanotechnology Reviews. 8. 61-78. 10.1515/ntrev-2019-0006.

Publisher : Nanotechnology Reviews

Year : 2019

Paper-Microfluidics based SERS substrate for PPB level detection of catechol

Cite this Research Publication : Hariharan, Abishek & Manohar, Sai & Muthukumar, Sai & Belliraj, Siva Kumar & Ferrari, Maurizio & Narasimha, Krishna & Vishnubhatla, Krishna. (2019). Paper-microfluidics based SERS substrate for PPB level detection of catechol.

Publisher : Optical Materials

Year : 2019

Optimization of cation-doped nano-hydroxyapatite in combination with amorphous aluminium hydroxide for defluoridation

Cite this Research Publication : Manohar, C. S.,Gupta, A.,Siva Kumar, B.,"Optimization of cation-doped nano-hydroxyapatite in combination with amorphous aluminum hydroxide for defluoridation", Water Supply, 19(6), 1686-1694

Publisher : Water Supply

Year : 2018

Drug repurposing of novel quinoline acetohydrazide derivatives as potent COX-2 inhibitors and anti-cancer agents

Cite this Research Publication : Manohar, Sai & Sridhar, P. & Kumar, Siva & Belliraj, Siva Kumar & Rajasekharareddy, Sabbasani. (2017). Drug repurposing of novel quinoline acetohydrazide derivatives as potent COX-2 inhibitors and anti-cancer agents. Journal of Molecular Structure. 1154. 10.1016/j.molstruc.2017.10.075.

Publisher : Journal of Molecular Structure, 1154, 437-444.

Year : 2018

Synthesis, NLO and Theoretical modeling of the Anti-inflammatory potential of six Dibenzylidene Cyclopentanone analogues of Curcumin

Cite this Research Publication : Manohar, Sai & Chakravarthy, Pavan & Belliraj, Siva Kumar. (2018). Synthesis, NLO and Theoretical modeling of the Anti-inflammatory potential of six DibenzylideneCyclopentanone analogues of Curcumin. Journal of Biological Research. Vol 35. 996-1008.

Publisher : Journal of Biological and Chemical Research, 35(2), 996-1008.

Year : 2018

Dielectric properties study of surface engineered nano TiO2/epoxy composites

Cite this Research Publication : Siddabattuni, Sasidhar & Akella, Sri Harsha & Abilash, Gangula & Belliraj, Sivakumar & Chunduri, Avinash. (2018). Dielectric properties study of surface engineered nanoTiO2/epoxy composites. Bulletin of Materials Science. 41. 10.1007/s12034-017-1526-6.

Publisher : Bulletin of Materials Science

Year : 2018

Innovative consortia of micro and macro fungal systems: cellulolytic enzyme production from groundnut shell biomass and supportive structural analysis

Cite this Research Publication : Thota, Sai Praneeth & Badiya, Pradeep Kumar & Guragain, Yadhu & Vadlani, Praveen & Pandey, Meera & Dandamudi, Rajesh babu & Ramamurthy, Sai & Belliraj, Siva Kumar. (2018). Innovative Consortia of Micro and Macro Fungal Systems: Cellulolytic Enzyme Production from Groundnut Shell Biomass and Supportive Structural Analysis. Journal of Sustainable Bioenergy Systems. 08. 47-66. 10.4236/jsbs.2018.83004.

Publisher : Journal of Sustainable Bioenergy Systems

Year : 2017

Synthesis, characterization and antimicrobial activities of copper, nickel, cobalt, chromium complexes derived from (Z)-4-Fluoro-N-(2, 7-dimethylhept-6-enylidene) benzenamine

Cite this Research Publication : Rao, Sridhar & BILAL, I.MOHAMMED & Deivanayagam, Easwaramoorthi & kutti rani, Srinivasalu & Belliraj, Siva Kumar & Manohar, Sai. (2016). Synthesis, Characterization and Antimicrobial Activities of Copper, Nickel, Cobalt, Chromium Complexes Derived from (Z)-4-Fluoro-N-(2,7-dimethylhept-6-enylidene) benzenamine. Journal of the Brazilian Chemical Society. 28. 10.21577/0103-5053.20160224.

Publisher : Journal of the Brazilian Chemical Society

Year : 2017

Silico Modelling of New C-12 Substituted-14-Deoxy-Andrographolide Derivatives as Potent Anticancer Leads

Cite this Research Publication : Kar, Swayamsiddha & Manohar, Sai & Kandanur, Sai Giridhar Sarma & Nanduri, Srinivas & Belliraj, Siva Kumar & Golakoti, Nageswara. (2017). In silico Modeling of New C-12 Substituted-14-Deoxy-Andrographolide Derivatives as Potent Anticancer Leads. Journal of Pharmacology & Clinical Toxicology. 5. 1083.

Publisher : Journal of Pharmacology & Clinical Toxicology

Year : 2017

Macro-micro fungal cultures synergy for innovative cellulase enzymes production and biomass structural analyses

Cite this Research Publication : Thota, S. P., Badiya, P. K., Yerram, S., Vadlani, P. V., Pandey, M., Golakoti, N. R., & Ramamurthy, S. S. Macro-micro fungal cultures synergy for innovative cellulase enzymes production and biomass structural analyses. Renewable Energy, 103, 766-773.

Publisher : Renewable Energy, 103, 766-773.

Year : 2017

Facile one-pot hydrothermal synthesis of stable and biocompatible fluorescent carbon dots from lemon grass herb

Cite this Research Publication : Thota, Sai & Thota, Sai Praneeth & Srimadh Bhagavatham, Sai Krishna & Manoj, Kaja & Muthukumar, Sai & Sivaramakrishnan, Venketesh & Vadlani, Praveen & Belliraj, Siva Kumar. (2017). Facile one-pot hydrothermal synthesis of stable and biocompatible fluorescent carbon dots from lemon grass herb. IET Nanobiotechnology. 12. 10.1049/iet-nbt.2017.0038.

Publisher : IET Nanobiotechnology

Year : 2017

Ag-protein plasmonic architectures for surface plasmon-coupled emission enhancements and Fabry-Perot mode-coupled directional fluorescence emission

Cite this Research Publication : Badiya, Pradeep Kumar & Patnaik, Sai & Sri, Venkatesh & Reddy, Narendra & Manohar, Sai & Vedarajan, Raman & Matsumi, Noriyoshi & Belliraj, Siva Kumar & Ramamurthy, Sai. (2017). Ag-Protein Plasmonic Architectures for Surface Plasmon-Coupled Emission Enhancements and Fabry-Perot Mode-Coupled Directional Fluorescence Emission. Chemical Physics Letters. 685. 10.1016/j.cplett.2017.07.056.

Publisher : Chemical Physics Letters

Year : 2016

Optical Sensing of Fluoride Through a Self-Organized Fluorescent Ensemble of Quinizarin-Al (III) Complex

Cite this Research Publication : Karnam, Lohith & Adurty, Sunil & Belliraj, Siva Kumar & Neelakantan, Sundaresan. (2016). Optical Sensing of Fluoride Through a Self-Organized Fluorescent Ensemble of Quinizarin-Al(III) Complex. Journal of AOAC International. 99. 10.5740/jaoacint.16-0045.

Publisher : Journal of AOAC International

Year : 2007

Synthesis, anti-fungal activity evaluation and QSAR studies on podophyllotoxin derivatives

Cite this Research Publication : Kruthiventi, Anil & Singh, Sanjay & Kumar, B. & Doble, Mukesh. (2007). Synthesis, anti-fungal activity evaluation and QSAR studies on podophyllotoxin derivatives. Central Eur. J. Chem.. 5. 880-897. 10.2478/s11532-007-0036-6.

Publisher : Open Chemistry

Conference Proceedings

Year : 2013

Novel D-π-A-π-D type organic chromophores for second harmonic generation and multi-photon absorption applications

Cite this Research Publication :
Proceedings of the International Conference on Trends in Applied Physics and Material Science: RAM 2013. AIP Conference Proceedings, Volume 1536. AIP Conference Proceedings, Volume 1536, Issue 1, p.751-752

Publisher : AIP Conference Proceedings

Book Chapter

Year : 2021

SARS-CoV-2—host cell interactions and pathways: understanding its physiology, pathology, and targeted drug therapy

Cite this Research Publication : Gonsalves, Rhea & Pacharla, Himavani & Manohar, Sai & Belliraj, Siva Kumar & Tripathi, Ekta & Karyala, Prashanthi & Pakala, Suresh. (2021). SARS-CoV-2—host cell interactions and pathways: understanding its physiology, pathology, and targeted drug therapy. 10.1016/B978-0-323-85662-1.00006-9.

Publisher : Pandemic Outbreaks in the 21st Century

Professional Appointments
Year Affiliation
August 2021 to present Assoc. Professor
Department of Chemistry. Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru.
October 2020 to August 2021 Head of Planning Sai Lakshmi Industries Private Limited, Bengaluru, Karnataka.
October 2017 (November 2018) to April 2020 Assoc. Professor (Assoc Head)
Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Puttaparthi, A. P.
July 2011 toOctober 2017 Assistant Professor
Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Puttaparthi, A. P.
September 2006 to June 2011 Lecturer
Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Puttaparthi, A. P.
November 2001 to August 2006 Teaching Assistant
Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Puttaparthi, A. P.
Research & Management Experience
  • Head, Department of Chemistry, PrasanthiNilayam Campus, SSSIHL. (2018-2020)
  • Supervisor
    • Graduated two Ph. D. students (SSSIHL)
  • Resource Person
    • Conducted a workshop in Recent Trends with Drug Design as a resource person in a St. Xavier’s PG college at Trivandrum.
    • Invited talk at Garden City University on Drug Designing and Autodock July 2021.
  • Extra Mural Project
    • Co-PI for a project SONEERA: Surface-water quality observation ‘N’ elimination of effluents using radio-frequency transmitter technology funded by Prasanthi Trust Inc. USA.
  • Institutional Grant
    • Conceptualized, fabricated and procured grant to set up single handedly the central computational Science Facility called COSMOS lab as part of the multi crore Central Research Instrumental Facility in the University.
Major Research Interests

RESEARCH TIMELINE

Multifunctional Materials Design: (2015 to present)

  • Optimizing dielectric and piezoelectric properties of hydroxyapatite composites in bone regenerative medicine.
  • Exploring new composites for bone cement, bone glue and studying its functions in orthopaedic applications.
  • Novel hydroxyapatite based bio-adsorbents for de-fluoridation
  • Computational material Science to optimize bone regeneration parameters.

Renewable Energy Design: (2014 to present)

  • Bioprocessing approach to maximize the production of ligno-cellulosic enzymes and subsequent conversion of monosaccharaides to ethanol, involving innovative consortia of micro and macro fungal cultures.
  • Luminescent carbon-basednano materials from Lemon grass biomass was isolated and evaluated for its photophysical behaviour, biocompatibility and low toxicity. These materials could be used as biomarkers.
  • The carbon materials with high porosity obtained from biomass charring was also tested for its energy storage capacity with respect to super-capacitor applications.
  • Experimental and theoretical support for HER reactions with novel nano substrates.

Computer Aided Drug Design (CADD): (2008 to present)

  • Molecular modelling via docking studies to establish the SAR and predictive co-relations for estimating activities in synthetic drug derivatives prior to synthesis of various biologically active drugs known for anti-cancer, anti-tuberculosis, and anti-inflammatory properties.
  • Drug re-purposing of established/ synthesized drugs for multifunctional potency.
  • Delineating the mechanistic rationale and the metabolic profiling of kinase inhibitors in CYP class of enzymes to metabolise erlotinib, in order to address the increasing concern in toxicity of drugs.
Membership in Professional Bodies
  • Life time member – ISCA – India Science Congress Association.
  • Key contact member – Scopus and Sci-Finder online Data Base (SSSIHL).
  • Annual Member – IMTA – Indian Music Therapy Association
  • Annual Member – ACRI – Arts and Cultural Resources of India
Certificates, Awards & Recognitions
  • Successfully completed the 5-day online FDP on the theme “Inculcating Universal Human Values in Technical Education” organized by All India Council for Technical Education(AICTE) from 8th November, 2021 to 12th November, 2021.
  • Successfully completed the 5 days’ workshop on “Introduction to Gaussian: Theory andPractice” conducted by Gaussian Inc, at Chennai in March 2016.
  • Completed a winter school on “Introduction to Ab-Initio calculations” at the UGC Network resourcing center School of Chemistry University of Hyderabad, 10thto 22nd December, 2012.
  • Successfully completed and secured an ‘A’ grade in the Orientation Program organized by the University of Kerala, Kariavottam Campus (UGC -ASC), as a part of the requirements forcareer advancement scheme for teachers, 4th to 31st March-2010.
Research Grants Received
Year Funding Agency Title of the Project Investigators Status
2018-2020 Prasanthi Trust Inc. USA. SONEERA: Surface-water quality observation ‘N’ elimination of effluents using radio-frequency transmitter technology Dr. Sai Sathish (PI) And Dr. B. Siva Kumar Co-Pi Completed.
Keynote Addresses/Invited Talks/Panel Memberships
  • Was an invited speaker for an online workshop on “Principles and applications of computational chemistry/biology” jointly organised by Garden City University in association with Karnataka Science and Technology Academy is organizing between the 14-16th July 2021.
  • Closing Keynote Speaker and also resource person for a two day conference organised by St. Xavier college Thumba, Trivandrum on the topic” Recent trends in Chemistry”. Between the 27th and 27th Sept, 2019
Courses Taught
  • Analytical Chemistry
  • Drug Design and computational chemistry
  • Solid state and structural chemistry
  • Organic Chemistry of Natural Products
  • Molecular spectroscopy
  • Bio organic chemistry
  • Industrial and Environmental chemistry
  • C language, Python.
Student Guidance

Postgraduate students – Total 19, All the projects have been Completed

Sl. No. Name of the Student(s) Topic Year of Completion
1 B.V.V. S. Pawan Kumar Investigation of a Novel and Efficient Chromophore for Anion Sensing 2009
2 Murthy -TBA-(To be added) 2010
3 Vamsi -TBA- 2010
4 Lohith K Fluoride sensing using quinizarin-al complex-A novel colorimetric method 2011
5 MihirKhatua -TBA- 2011
6 Chelli Sai Manohar Molecular docking approach to evaluating inhibitory activity of camptothecin and its derivatives on dna – topoisomerase i 2012
7 Amrit V Molecular docking approach to evaluate inhibitory activity of isoniazid and its derivatives against enoyl – acp reductase 2013
8 Hari -TBA- 2013
9 Varun Hari Docking studies to examine the role of pyrazinamide as anantituberculosis drug 2013
10 Chakravarthy Synthesis, characterization, nonlinear optical and theoretical studies of some dibenzylidenecyclopentanone analogues of curcumin. 2014
11 Parth Gupta Dft and molecular docking approaches to predict cyp3a4 mediated metabolism of small molecule kinase inhibitors 2015
12 Brahma Teja Use of mos2 as a catalyst in hydrogen evolution reaction and identification of the catalytic surface morphologies 2016
13 Abinash Pradhan In Silico structural elucidation of polydopamine as a biopolymeric binder in enhancing piezoelectricity of nano-hydroxyapatite composite. 2017
14 Kaja Sai Manoj Supercapacitor Power Cells Based on Peanut Shell Derived Carbon 2017
15 Agman Gupta Use of Cation Doped HA-HA Nanorods-Amorphous Aluminium Hydroxide for Defluoridation of water. 2018
16 Anurag Shastri Fluoride on Thyroid: A computational Study. 2018
17 Vijay R “Effect of Torsional Disorder on Exciton Migration in Linear Conjugated Polymers” 2019
18 Prasad K -TBA- 2020
19 Surya Molecular docking studiesand investigation of non-linear properties oftwo classes of dibenzylideneacetone 2020

Research Scholars

Sl. No. Name of the Student(s) Topic Status – Ongoing/ Completed Year of Completion
1 Thota Sai Praneeth Enzymatic Hydrolysis of Groundnut Shell to Sugars and Biomass-derived Carbon Nanomaterials for Renewable Energy Applications Completed 2018
2 Chelli Sai Manohar Synthetic and in silico strategies for designing drugs, probing sensing mechanisms and optimizing novel HA-BCZT piezo-materials for bone regeneration Completed 2019
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