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Dr. Aparup Patra

Assistant Professor, Amrita Research Center, Amrita Vishwa Vidyapeetham, Faridabad

Qualification: MSc, Ph.D
aparuppatra@fbd.amrita.edu

Bio

Dr. Aparup Patra obtained his M.Sc. in Biotechnology (2015) from KIIT University, Bhubaneswar, Odisha, and his Ph.D. in Molecular Biology and Biotechnology (2021) from Tezpur University, Assam. His doctoral research focused on the biochemical, pharmacological, proteomic, and antivenomics characterization of Big Four snake venoms, as well as the assessment of the quality and safety of commercial antivenoms. After completing his Ph.D., Dr. Patra joined the Institute of Advanced Study in Science and Technology, Guwahati (an autonomous R&D institute under DST) as a Post-Doctoral Fellow. His post-doctoral work centered on drug discovery for neurodegenerative diseases, particularly Parkinson’s disease, using natural resources such as snake venom and traditional medicinal plants. Dr. Patra has presented his work at numerous national and international conferences, receiving the Best Presenter Award at the International Conference on Proteins and Proteomics organized by the Proteomics Society of India. He has published 30 research articles, 5 conference proceedings, 1 book chapter, and holds 2 provisional or full patents.

Publications

Journal Article

Year : 2024

Phytomedicine for neurodegenerative diseases: The road ahead

Cite this Research Publication : Madhubala D., Patra A., Khan M. R., Mukherjee, A. K, Phytomedicine for neurodegenerative diseases: The road ahead,  Phytotherapy Research, 38 (6), 2993-3019 [IF-6.1], 2024.

Year : 2024

Composition, pharmacology, and pathophysiology of the venom of monocled cobra (Naja kaouthia)- a medically crucial venomous snake of southeast Asia: An updated review☆

Cite this Research Publication : Kakati H., Patra A.,Mukherjee A. K, Composition, pharmacology, and pathophysiology of the venom of monocled cobra (Naja kaouthia)-a medically crucial venomous snake of southeast Asia: an updated review, Toxicon, 108056, 2024.

Publisher : Elsevier

Year : 2024

Macrophage foam cell-derived mediator promotes spontaneous fat lipolysis in atherosclerosis models

Cite this Research Publication : Banerjee D., Patra D., Sinha A., Chakrabarty D., Patra A., Sarmah R.,Dasgupta S, Macrophage foam cell-derived mediator promotes spontaneous fat lipolysis in atherosclerosis models, Journal of Leukocyte Biology, qiae210, 2024.

Year : 2024

Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of Indian Big Four and Naja kaouthia snake venoms

Cite this Research Publication : Chanda A, Salvi N.C, Shelke P.V, Kalita B, Patra A, Puzari U, Khadilkar M.V, Mukherjee A.K, Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of Indian Big Four and Naja kaouthia snake venoms, Toxicon: X,2024

Publisher : Elsevier

Year : 2023

In vitro laboratory analyses of commercial anti-scorpion (Mesobuthus tamulus) antivenoms reveal their quality and safety but the prevalence of a low proportion of venom-specific antibodies

Cite this Research Publication : Das B., Patra A., Puzari U., Deb P.,Mukherjee A. K, In vitro laboratory analyses of commercial anti-scorpion (Mesobuthus tamulus) antivenoms reveal their quality and safety but the prevalence of a low proportion of venom-specific antibodies, Toxicon, 215, 37-48, 2023.

Publisher : Elsevier

Year : 2023

Snake venom nerve growth factor-inspired designing of novel peptide therapeutics for the prevention of paraquat-induced apoptosis, neurodegeneration, and alteration of metabolic pathway genes in the rat pheochromocytoma PC-12 cell

Cite this Research Publication : Madhubala D., Patra A., Islam T., Saikia K., Khan M. R., Ahmed S. A., Mukherjee A. K, Snake venom nerve growth factor-inspired designing of novel peptide therapeutics for the prevention of paraquat-induced apoptosis, neurodegeneration, and alteration of metabolic pathway genes in the rat pheochromocytoma PC-12 cell, Free Radical Biology and Medicine 197, 23-46, 2023.

Publisher : Elsevier

Year : 2023

Computational and in vitro analyses to identify the anticoagulant regions of Echicetin, a snake venom anticoagulant C-type lectin (snaclec): possibility to develop anticoagulant peptide therapeutics?

Cite this Research Publication : Puzari U., Goswami M., Rani K., Mukherjee A. K, Computational and in vitro analyses to identify the anticoagulant regions of Echicetin, a snake venom anticoagulant C-type lectin (Snaclec): Possibility to develop anticoagulant peptide therapeutics?, Journal of Bimolecular Structure and Dynamics, 2023.

Year : 2023

A Novel Therapeutic Formulation for the Improved Treatment of Indian Red Scorpion (Mesobuthus tamulus) Venom-Induced Toxicity-Tested in Caenorhabditis elegans and Rodent Models

Cite this Research Publication : Das B., Madhubala D., Mahanta S., Patra A., Puzari U., Khan M. R.,Mukherjee, A. K, A Novel Therapeutic Formulation for the Improved Treatment of Indian Red Scorpion (Mesobuthus tamulus) Venom-Induced Toxicity-Tested in Caenorhabditis elegans and Rodent Models, Toxins, 15(8), 504, 2023

Year : 2023

The application of laboratory-based analytical tools and techniques for the quality assessment and improvement of commercial antivenoms used in the treatment of snakebite envenomation

Cite this Research Publication : Patra A.,Herrera M., Gutiérrez, J. M., Mukherjee A. K, The application of laboratory-based analytical tools and techniques for the quality assessment and improvement of commercial antivenoms used in the treatment of snakebite envenomation, Drug Testing and Analysis, 2023.

Year : 2023

Therapeutic Potential of Bioactive Compounds from Edible Mushrooms to Attenuate SARS-CoV-2 Infection and Some Complications of Coronavirus Disease (COVID-19)

Cite this Research Publication : Baruah P., Patra A., Barge S., Khan M.R.,Mukherjee, A. K, Therapeutic potential of bioactive compounds from the edible mushrooms to attenuate SARS-COV-2 infection and some complications in Coronavirus disease (COVID-19), Journal of Fungi, 2023.

Year : 2023

A Correlation Study to Comprehend the SAR-CoV-2 Viral Load, Antiviral Antibody Titer, and Severity of COVID-19 Symptoms Post-infection Amongst the Vaccinated Population in Kamrup District of As sam, Northeast India

Cite this Research Publication : Patra A., Bala A., Khan M.R.,Mukherjee A. K, A Correlation Study to Comprehend the SAR-COV-2 Viral Load, Antiviral Antibody Titer, and Severity of COVID-19 Symptoms Post-Infection Amongst the Vaccinated Population in Kamrup District of Assam, Northeast India, Endocrine, Metabolic & Immune Disorders-Drug Targets,2023.

Year : 2023

A Correlation Study to Comprehend the SAR-CoV-2 Viral Load, Antiviral Antibody Titer, and Severity of COVID-19 Symptoms Post-infection Amongst the Vaccinated Population in Kamrup District of As sam, Northeast India

Cite this Research Publication : Patra, A., Bala, A., Khan M.R., and Mukherjee, A. K, A Correlation Study to Comprehend the SAR-COV-2 Viral Load, Antiviral Antibody Titer, and Severity of COVID-19 Symptoms Post-Infection Amongst the Vaccinated Population in Kamrup District of Assam, Northeast IndiaEndocrine, Metabolic & Immune Disorders-Drug Targets, 2023.

Year : 2023

A retrospective analysis of epidemiology, clinical features of envenomation, and in-patient management of snakebites in a model secondary hospital of Assam, North-east India

Cite this Research Publication : Kakati, H., Giri, S., Patra, A., Taye, S.J., Agarwalla, D., Baruah, H., Choudhary, G., Kalita, B. and Mukherjee, A.K., A retrospective analysis of epidemiology, clinical features of envenomation, and in-patient management of snakebites in a model secondary hospital of Assam, North-east India, Toxicon, p.107175,2023.

Year : 2022

Mushroom mycetism – A neglected and challenging medical emergency in the Indian subcontinent: A road map for its prevention and treatment

Cite this Research Publication : Patra A.,Mukherjee A. K, Mushroom mycetism- a neglected and challenging medical emergency in the Indian subcontinent: A road map for its prevention and treatment, Toxicon, 217, 56-77, 2022

Publisher : Elsevier

Year : 2022

A comparison of two different analytical workflows to determine the venom proteome composition of Naja kaouthia from North-East India and immunological profiling of venom against commercial antivenoms

Cite this Research Publication : Kakati H, Patra A, Kalita B, Chanda A, Rapole S,Mukherjee A.K, A comparison of two different analytical workflows to determine the venom proteome composition of Naja kaouthia from North-East India and immunological profiling of venom against commercial antivenoms, International Journal of Biological Macromolecules, 208, 275-287,2022

Publisher : Elsevier

Year : 2021

Assessment of snakebite burdens, clinical features of envenomation, and strategies to improve snakebite management in Vietnam

Cite this Research Publication : Patra, A., Mukherjee, A. K, Assessment of snakebite burdens, clinical features of envenomation, and strategies to improve snakebite management in Vietnam, Acta Tropica, 105833, 1-14, 2021

Publisher : Elsevier

Year : 2021

The in vitro laboratory tests and mass spectrometry-assisted quality assessment of commercial polyvalent antivenom raised against the ‘Big Four’ venomous snakes of India

Cite this Research Publication : Patra, A., Banerjee, D., Dasgupta, S., & Mukherjee, A. K, The in vitro laboratory tests and mass spectrometry-assisted quality assessment of commercial polyvalent antivenom raised against the ‘Big Four’ venomous snakes of India, Toxicon, 192, 15-31,2021.

Publisher : Elsevier

Year : 2021

Assessment of quality and pre-clinical efficacy of a newly developed polyvalent antivenom against the medically important snakes of Sri Lanka

Cite this Research Publication : Patra A, Kalita B, Khadilkar M.V, Salvi N.C, Shelke P.V, Mukherjee A.K, Assessment of quality and pre-clinical efficacy of a newly developed polyvalent antivenom against the medically important snakes of Sri Lanka, Nature Scientific Reports, 11(1), 1-17,2021

Year : 2020

Species-specific and geographical variation in venom composition of two major cobras in Indian subcontinent: Impact on polyvalent antivenom therapy

Cite this Research Publication : Mukherjee A. K., Chanda A., Patra A, Species-specific and geographical variation in venom composition of Indian cobra: Impact on polyantivenom therapy, Toxicon, 182, S3-S4, 2020.

Publisher : Elsevier

Year : 2020

Correlation of Venom Toxinome Composition of Indian Red Scorpion (Mesobuthus tamulus) with Clinical Manifestations of Scorpion Stings: Failure of Commercial Antivenom to Immune-Recognize the Abundance of Low Molecular Mass Toxins of This Venom

Cite this Research Publication : Das B., Patra A., Mukherjee A. K, Correlation of venom toxinome composition of Indian red scorpion (Mesobuthus tamulus) with clinical manifestations of scorpion stings: failure of commercial antivenom to immune-recognize the abundance of low molecular mass toxins of this venom, Journal of Proteome Research, 19(4), 1847-1856, 2020

Year : 2020

Proteomic Analysis of Sri Lanka Echis carinatus Venom: Immunological Cross-Reactivity and Enzyme Neutralization Potency of Indian Polyantivenom

Cite this Research Publication : Patra A., Mukherjee A. K, Proteomic analysis of Sri Lanka Echis carinatus Venom: Immunological cross-reactivity and enzyme neutralization potency of Indian polyantivenom, Journal of Proteome Research, 2020

Year : 2019

Quantitative proteomic analysis of venom from Southern India common krait (Bungarus caeruleus) and identification of poorly immunogenic toxins by immune-profiling against commercial antivenom

Cite this Research Publication : Patra A., Chanda A.,Mukherjee A. K, Quantitative proteomic analysis of venom from Southern India common krait (Bungarus caeruleus) and identification of poorly immunogenic toxins by immune-profiling against commercial antivenom, Expert Review of Proteomics, 16(5), 457-469, 2019

Year : 2019

Proteomic analysis and antivenomics study of Western India Naja naja venom: correlation between venom composition and clinical manifestations of cobra bite in this region

Cite this Research Publication : Chanda A, Kalita B, Patra A, Senevirathne W.D.S.T, Mukherjee A.K, Proteomic analysis and antivenomics study of Western India Naja naja venom: Correlation between venom composition and clinical manifestations of cobra bite in this region, Expert Review of Proteomics, 16(2), 171-184, 2019

Year : 2018

Assessment of quality, safety, and pre-clinical toxicity of an equine polyvalent anti-snake venom (Pan Africa): Determination of immunological cross-reactivity of antivenom against venom samples of Elapidae and Viperidae snakes of Africa

Cite this Research Publication : Patra, A., Kalita B., Mukherjee A. K, Assessment of quality, safety, and pre-clinical toxicity of an equine polyvalent anti-snake venom (Pan Africa): Determination of immunological cross-reactivity of antivenom against venom samples of Elapidae and Viperidae snakes of Africa, Toxicon, 153, 120-127, 2018.

Publisher : Elsevier

Year : 2018

First report of the characterization of a snake venom apyrase (Ruviapyrase) from Indian Russell’s viper (Daboia russelii) venom

Cite this Research Publication : Kalita B., Patra A., Jahan S.,Mukherjee A. K, First report of the characterization of a snake venom apyrase (Ruviapyrase) from Indian Russell's viper (Daboia russelii) venom, International Journal of Biological Macromolecules, 111, 639-648, 2018.

Publisher : Elsevier

Year : 2018

Quantitative proteomic analysis and antivenom study revealing that neurotoxic phospholipase A2 enzymes, the major toxin class of Russell’s viper venom from southern India, shows the least immuno-recognition and neutralization by commercial polyvalent antivenom

Cite this Research Publication : Kalita B, Singh S, Patra A, Mukherjee A. K, Quantitative proteomic analysis and antivenom study revealing that neurotoxic phospholipase A2 enzymes, the major toxin class of Russell's viper venom from southern India, shows the least immuno-recognition and neutralization by commercial polyvalent antivenom, International Journal of Biological Macromolecules, 118(A), 375-385, 2018.

Publisher : Elsevier

Year : 2018

Proteomic Analysis and Immuno-Profiling of Eastern India Russell’s Viper (Daboia russelii) Venom: Correlation between RVV Composition and Clinical Manifestations Post RV Bite

Cite this Research Publication : Kalita B, Patra A, Das A, Mukherjee A. K, Proteomic analysis and immuno-profiling of eastern India Russell’s viper (Daboia russelii) venom: Correlation between RVV composition and clinical manifestations post RV bite, Journal of Proteome Research, 17(8), 2819-2833, 2018

Year : 2017

Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties

Cite this Research Publication : Dutta S., Chanda A., Kalita B., Islam T., Patra A., Mukherjee A. K, Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties, Journal of Proteomics, 156, 29-39, 2017

Publisher : Elsevier

Year : 2017

Proteomics and antivenomics of Echis carinatus carinatus venom: Correlation with pharmacological properties and pathophysiology of envenomation

Cite this Research Publication : Patra A., Kalita B., Chanda A., Mukherjee A. K, Proteomics and antivenomics of Echis carinatus carinatus venom: Correlation with pharmacological properties and pathophysiology of envenomation, Nature Scientific Reports, 7(1), 17119, 2017

Year : 2017

Unraveling the Proteome Composition and Immuno-profiling of Western India Russell’s Viper Venom for In-Depth Understanding of Its Pharmacological Properties, Clinical Manifestations, and Effective Antivenom Treatment

Cite this Research Publication : Kalita B, Patra A, Mukherjee A. K, Unravelling the proteome composition and immuno-profiling of western India Russell’s viper venom for in-depth understanding of its pharmacological properties, clinical manifestations, and effective antivenom treatment, Journal of Proteome Research, 16(2), 583–598, 2017

Book Chapter

Year : 2021

Snake envenomation: therapy and challenges in India

Cite this Research Publication : Mukherjee A. K., Kalita B., Dutta S., Patra A., Maiti C. R.,Punde D, Snake envenomation: therapy and challenges in India, Handbook of Venoms and Toxins of Reptiles, 2021.

National Patents Filed

National Patents Filed (under examination)

  1. Mukherjee A.K., Dutta S., Kalita B., Chanda A., Patra A., Toxins-targeted specific novel anti-snake venom, Application No. 201831038837, Indian Patent Office,2018
  2. Mukherjee A.K., Patra A, Rajbongshi B., Khan M.R, A polyherbal formulation for the prevention of toxic chemicals-induced neurodegenerative diseases. Application No. 202431016767, Indian Patent Office, 2024.
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