Course

Classification of the illnesses, etiology (genetic mutations involved in the disease) controlled mechanism and pathophysiology, clinical manifestations, complications, management including pharmacological (including selection of drug with appropriate doses, standard treatment guidelines, newer available therapy including gene therapy associated with individualized therapy, pharmacokinetics and pharmacodynamics of the therapy, ADRs, contraindications with an emphasis on vulnerable population) and non-pharmacological treatment.

Unit 1

UNIT -I NERVOUS SYSTEM 12 hours

Epilepsy 02 hours

Parkinson’s Disease 02 hours

Alzheimer’s Disease 02 hours

Stroke 03 hours

Neuralgias 03 hours

UNIT -II PSYCHIATRIC DISORDERS 06 hours

Schizophrenia 02 hours

Depression 02 hours

Anxiety disorders 02 hours

Unit 2

UNIT III-INFECTIOUS DISEASE

15 hours

General guidelines for the rational use of antibiotics and surgical

prophylaxis

02 hours

Urinary tract infections

02 hours

Respiratory tract infections-pneumonia, influenza

04 hours

Tuberculosis

02 hours

Malaria

02 hours

HIV and opportunistic infections

03 hours

Unit 3

UNIT IV-ONCOLOGY 12 hours

General principles of cancer chemotherapy 02 hours

Pharmacotherapy of:

Breast Cancer 02 hours

Lung Cancer 02 hours

Haematological malignancies 04 hours

Management of nausea and vomiting 02 hours

Course provides an opportunity to learn the etiopathogenesis, signs and symptoms , pharmacotherapeutic management of various diseases including recent advances, approved treatment algorithms and guidelines. It gives an insight into the basis behind the selection of drugs in disease management and the role of pharmacological and non-pharmacological interventions. This course also highlights understanding, detection, assessment and prevention of various drug related problems. Recent advances in Pharmacotherapy and patient-specific management strategies are included and emphasized. It emphasizes student- directed acquisition of necessary knowledge in the management of various diseases.

It imparts knowledge and skills necessary for the rational use of medicines. The focus of this unit of study is to help students gain a grasp of how to use medications and related acceptable health measures in particular patient populations, including children, the elderly, pregnant women, people with disabilities, and special patient groups. Concepts from clinical practice, pharmacokinetics, and clinical pharmacy will all be incorporated into this unit of study. Students will engage in activities such as case-study analysis, role-plays, problem solving, and case presentations during study period. Through these exercises, students will be able to investigate drug-related information sources and apply their understanding of clinical indices, laboratory results, medication usage patterns, and demographic data to tailor drug therapy to the specific requirements of each patient. Students will receive “hands-on” training in educating patients on medication history review, medication reconciling, about the use of medications, as well as an exploration of important concerns related to maintaining vigilance over the use of medications relevant to particular population groups.

KNOWLEDGE

K1: Define various disorders and their characteristics.

K2: Describe the etiopathogenesis, clinical manifestations, and complications of specified diseases.

K3: Identify patient-specific parameters relevant to initiating and continuing drug therapy. K4: Explain both non-pharmacological and pharmacological approaches for managing various diseases.

K5: Illustrate standard treatment guidelines for various diseases and disorders.

K6: Analyze the rationale behind the current treatment algorithms for managing various diseases.

SKILL

S1: Compare a patient’s current treatment regimen with approved treatment algorithms for various diseases.

S2: Recognize and assess various drug-related problems.

S3: Justify changes in drug therapy based on patients’ clinical outcomes.

S4: Discuss effective patient counseling techniques.

S5: Apply pharmacological knowledge to prevent and treat various disorders.

S6: Resolve drug-related problems encountered in patient drug therapy.

ATTITUDE

A1: Communicate effectively with patients and other healthcare professionals.

A2: Demonstrate professionalism in all clinical activities.

A3: Exhibit sincerity, punctuality, and integrity in both academic and non-academic activities.

A4: Support and collaborate with various stakeholders in the healthcare environment.

A5: Adhere to ethical standards in maintaining patient confidentiality.

A6: Value and promote the effective reporting of drug-related problems among healthcare professionals.

REFERENCE BOOKS

1. Joseph DiPiro. DiPiro’s Pharmacotherapy Handbook, 12th Edition.2023
2. Koda Applied Therapeutics: The clinical use of drugs,12th edition. 2024
3. Walker Clinical Pharmacy and Therapeutics. 5th Edition. Elsevier Health Sciences; 2011.

4. Eric T. Herfindal. Clinical Pharmacy and Therapeutics – 7^th, Williams and Wilkins Publication ; 2000.

JOURNALS:

Lau KH, Tan AM, Shi Y. New and Emerging Targeted Therapies for Advanced Breast Cancer. Int J Mol Sci. 2022 Feb 18;23(4):2288. doi: 10.3390/ijms23042288. PMID: 35216405;

Lemjabbar-Alaoui H, Hassan OU, Yang YW, Buchanan P. Lung cancer: Biology and treatment options. Biochim Biophys Acta. 2015 Dec;1856(2):189-210. doi: 10.1016/j.bbcan.2015.08.002. Epub 2015 Aug 19. PMID: 26297204;.

WEB RESOURCES

• Psychiatric Guidelines : https://www.psychiatry.org/Psychiatrists/Education
• Epilepsy : https://www.ilae.org/guidelines

LIST OF ASSIGNMENTS:

1. Understand the evidence based psychotherapy for schizophrenia
2. Describe current management and challenges of invasive fungal infections in ICU
3. Explain the recent advancement in management of stroke
4. Summarize the innovative research approaches for cancer treatment: current perspectives and new challenges
5. Describe the current status and future directions in the management of advanced stage of chronic myeloid leukemia
6. List out the monitoring parameters during antipsychotic therapy
7. Understand the clinical complications arising out of Hospital acquired pneumonias
8. Prepare a case on Drug induced psychiatric disorders
9. Prepare an assignment on the recent FDA approved drugs related to all the various