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Syllabus

Unit 1

Nomenclature of Organic compounds: Polyenes, Alkynes with and without functional groups by IUPAC nomenclature. Aromatic and Heteroaromatic systems – nomenclature of heterocycles having not more than two hetero atoms such as oxygen, sulphur, nitrogen.

Stereochemistry: Tacticity, R/S system of nomenclature of central and axial molecules.

Unit 2

Atropisomerism – isomerism of biphenyls – allenes and spiranes – ansa compounds – Geometrical isomerism, E, Z Isomerism. Asymmetric synthesis.

Conformational Analysis: Optical activity and chirality – Conformational Analysis of cyclic and acyclic system – Conformational effects on reactivity of acyclic systems only.

Unit 3

Asymmetric synthesis: Stereo selective – Stereo specific – Regioselective and Regiospecific reactions. Principle of protection of alcohol, amine, carboxyl and carbonyl groups – Functional group inter conversions – Disconnection approach – Reversal of polarity – reagents in synthesis.

Text Books

  1. E. L. Eliel, “Stereochemistry of Carbon Compounds”, McGraw Hill Book Co, (2000).
  2. Jerry March, “Advanced Organic Chemistry”, 4th edition, John Wiley & Sons, (1992).

Resources

  • S. Warren, “Designing Organic Synthesis”, Wiley & Sons, (1998).
  • Finar I. L, “Organic Chemistry: Stereochemistry and the Chemistry of Natural Products”, 5th edition, ELBS, (2000).

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