| Course Name | Neurobiology: Chemical and Architectural Organization of Brain |
| Course Code | 24MMD542 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Faridabad, Kochi |
The heterogeneous group of cells that constitute the nervous tissue and functions as a system is an architectural organization composed of highly organized networks with different functions compartmentalized in different cell types for the efficient execution of impulse conduction, cognition, memory and conscience at time space level. Basic understanding of this organization is essential for understanding neurobiology.
Introduction: Introduction to Nervous System. Why it is considered as system and its conceptual difference from tissue. Concept of neurobiology; Levels of neural organization. Neurons and Glia. Importance of neuronal polarity and Axonal integrity.
Neuronal polarization at molecular, structural and functional level and its significance in the molecular and architectural organization of neuron and oligodendrocytes. Structural and functional polarity of neuron in impulse conduction. Importance of myelin and myelination. Myelin axolemmal junctions and its biochemical make up. Significance of Myelin-axolemmal complexities in impulse conduction. How disturbances in this organization leads to variety of disorders.
Myelin biology and its components. Role of myelin protein in the architectural organization of myelin. Different molecules that contribute to structural integrity and maintenance of myelin and how they are affected in various neuronal diseases. Organization of myelin at node, paranodes and internodes. Different levels of brain organization. Diseases affecting the myelin.
Axonal transport (anterograde and retrograde transport and its significance), vesicle trafficking and regulation; Neuronal growth, survival and development; Glia biology, role of astrocytes, oligodendrocytes and their concerted action in supporting neuronal function,
Electrical properties of membrane in the context of myelin organization; Membrane potential; Ion channels; Properties of axons and dendrites; Action potential; Synapse; Synaptic potential and integration; Directly and indirectly gated neurotransmitter receptors; Secretion, Memory formation and the role of signaling mechanisms. Synaptic plasticity, Long term potentiation.
Pre-requisites: Basic understanding of cell biology
Total number of classes: 45
Preamble
The heterogeneous group of cells that constitute the nervous tissue and functions as a system is an architectural organization composed of highly organized networks with different functions compartmentalized in different cell types for the efficient execution of impulse conduction, cognition, memory and conscience at time space level. Basic understanding of this organization is essential for understanding neurobiology.
Course Outcome
CO1 Provides a basic understanding about the organization of the brain
CO2 A deeper explanation of different types of cells that constitute brain organization
CO3 Significance of the different cell types in the formation of functional unit of neuron and how this is achieved and maintained
CO4 Importance of functional unit of neuron in organizing structural and functional polarity
CO5 Significance of structural and functional organization in the chemical complexity related to impulse conduction, transport of molecules and complexes for transmission of impulses and its association with disease.
Programme Outcomes (PO) (As given by NBA and ABET)
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
|
C |
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
|
C O |
||||||||||||
|
CO 1 |
3 |
1 |
1 |
1 |
– |
– |
– |
– |
– |
– |
– |
1 |
|
CO 2 |
3 |
1 |
1 |
– |
– |
_ |
1 |
|||||
|
CO 3 |
3 |
2 |
1 |
2 |
1 |
– |
1 |
|||||
|
CO 4 |
3 |
2 |
3 |
2 |
– |
1 |
1 |
|||||
|
CO 5 |
3 |
3 |
2 |
2 |
1 |
3 |
– |
– |
– |
– |
– |
1 |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular dysregulation in diseases
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cell based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
|
C |
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
PSO7 |
PSO8 |
PSO9 |
PSO10 |
|
CO |
||||||||||
|
CO 1 |
3 |
1 |
1 |
1 |
1 |
– |
– |
2 |
– |
– |
|
CO 2 |
3 |
– |
– |
– |
– |
_ |
– |
1 |
– |
– |
|
CO 3 |
3 |
– |
– |
– |
1 |
– |
– |
2 |
– |
– |
|
CO 4 |
– |
– |
– |
2 |
– |
– |
– |
2 |
– |
– |
|
CO 5 |
3 |
3 |
3 |
2 |
2 |
– |
– |
2 |
– |
– |
Evaluation Pattern: 50+50 = 100
|
Internal Assessment – 50% |
||
|
Periodical 1 |
Exam |
20% |
|
Periodical 2 |
Exam |
20% |
|
Continuous Assessment |
Assignment/Test/Quiz |
10% |
|
50% |
||
|
End Semester Examination- 50% |
||
|
Theory Exam |
50% |
|
|
50% |
||
|
Total |
100% |
|
Text Book
Principles of Neural Science, Fifth Edition (Principles of Neural Science (Kandel) 2012 McGraw-Hill Education / Medical by Eric Kandel and James Schwartz
References:
Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology by Scott Brady and George Siegel (2011)
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