Course

Unit 1

Concepts of Nanomedicine Controlled drug delivery, Advantages of nanotechnology in drug delivery, Design, fabrication, evaluation and applications of the nanosystems for drug and gene delivery Polymeric Nanoparticles, Liposomes, Micelles, Solid Lipid Nanoparticles, Dendrimers, Implants and inserts, General characteristics of nanomaterials used in drug/gene delivery Drug encapsulation, Drug release, Effect of particle size/surface charge in drug delivery

Unit 2

Nano Drug Delivery via Different Routes: Oral Drug Delivery – Concepts of Mucoadhesion; Intravenous Drug Delivery using nanoparticles – Concept of opsonisation; Transdermal, Intranasal and Ocular Drug Delivery using Nanoparticles, Strategies for Advanced Drug Delivery:-Prodrug and Bioconjugation; Concept of Drug Targeting, Site Specific Drug delivery utilizing Monoclonal Antibodies, Peptides and other biomolecules, Nanovaccines

Unit 3

Medical Diagnosis– from biomarkers to cells and tissues; Clinical diagnostic imaging tools: MRI, PET, CT, Ultrasound, Nuclear and Optical imaging an overview; Diagnostic nanoscale materials in imaging; Molecular imaging techniques

Unit 4

Nanobiosensors in diagnosis– electrochemical sensors, enzymatic and non-enzymatic sensors, cantilever based sensors, piezoelectric biosensors, Lab-on-a-chip concept, Microfluidics, surface enhanced Raman spectroscopy based diagnostics, surface plasmon based biosensors; Current nanotechnology based diagnostics in use and under clinical trials.

Pre-requisites: Basic level physics, chemistry and biology

Total number of classes: 45

COURSE OUTCOMES:

Upon successful completion, students will have the knowledge and skills to:

• Understand the fundamental concepts of nanomedicine
• Comprehend the factors controlling the pharmacokinetics of various drug formulations
• Understand the benefits of nanodrug delivery
• Various types of advanced drug delivery systems based on nanotechnology
• Concepts of targeted drug delivery
• An overview of the medical diagnostic tools
• Introduction to the nanomaterials in medical diagnostics
• Understanding about various nano bio-sensors and microfluidic sensors
• Understanding the current status of nanotechnology based diagnostic devices commercially available and under clinical trials

1. Drug Delivery Systems, Pieter Stroeve and Morteza Mahmoudi, World Scientific Series: From Biomaterials towards Medical Devices, Vol I, 2018.
2. Nanoparticulates as Drug Carriers, Vladimir Torchillin, Imperial College Press, 2006
3. Emerging nanotechnologies for diagnostics, drug delivery and medical devices, Kishore Cholkar, Abhirup Mandal, Ashim Mitra, Elsevier (2017)
4. Nanobiosensors and Nanobioanalyses, Vestergaard MC, Kerman K, Hsing IM, Tamiya E, Springer 2015

Current Medical Diagnosis and Treatment, Maxine A Papadakis, McGraw Hill Education,