Course

Unit 1

Introduction to Biomaterials: Basic concepts of biomaterials science, definition, Concept of biocompatibility.

Classes of biomaterials in Medicine: Metals, Ceramics, Polymers, Composites; Bioresorbable; Bioinert, Bioactive and Biomimetic Materials, Materials at the Nanoscale nanoparticles, nanofibers, nanocomposites

Unit 2

Biomaterials Fabrication: Solvent casting, salt leaching and lyophilisation, Electrospinning, Hydrogels, Cryogels, Surface modified biomaterials, 3D printing, 3D bioprinting-Cell encapsulation, Current advances and challenges in 3D printing.

Unit 3

Material-tissue interactions: Protein and Cell-Material interactions, Blood – material interactions, Inflammatory and immune response to biomaterials, Angiogenic response to biomaterials

Influence of Nanoscale Properties on Cellular Interactions – Porosity, Mechanical strength, Surface characteristics & modifications, Degradation

Pre-requisites: Undergraduate level basic physics, chemistry and biology

Total number of classes: 45

COURSE OUTCOMES:

Students on completion of this course will

• Understand the basic concept of a biomaterial and its applications in medicine
• Comprehend the different types of biomaterialsuseful in diverse biomedical applications, with their specific properties
• Decipher the interactions of biomaterials with tissues and how nanoscale size effects influence the biological interactions
• Learn about the diverse biofabrication techniques for developing biomaterial scaffolds

1. Biomaterials Science: An Introduction to Materials in Medicine, Edited by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen,Jack E. Lemons. 2020
2. Ying Deng and Jordan Kuiper, Functional 3D Tissue Engineering Scaffolds: Materials, Technologies, and Applications (Woodhead Publishing Series in Biomaterials), 2017
3. .Cato T. Laurencin, Lakshmi S. Nair. Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition, CRC Press 2017