Course

Unit 1

Fundamental concepts of drug delivery: Physicochemical Properties of Drugs, Effects of fundamental physicochemical properties on the biopharmaceutical behavior of drugs, Concentration-time curve of pharmacokinetics; Fundamentals of controlled drug delivery, Pharmacokinetic and pharmacodynamic basis of controlled drug delivery, Physicochemical and biological factors influencing design and performance of controlled release products.

Unit 2

Routes of Drug Delivery: Enteral Oral, Sublingual, Buccal, Rectal; Parenteral Intravenous, Intramuscular, Intra-arterial, Intra-thecal, Intradermal; Topical Transdermal, Intranasal, Conjuctival; Conventional drug delivery systems; Concept of active and passive targeting of drugs

Unit 3

Introduction to pharmacokinetics; Route of administration of drugs; Pharmacokinetic Parameters bioavailability, biological Half-life, volume of distribution and clearance; Absorption of drugs; Mechanism of drug absorption; Factors affecting drug absorption; Distribution of drugs; Protein binding of drugs; Factors affecting distribution of drugs; Metabolism of drugs; Excretion of drugs; Kinetic models</

Unit 4

Introduction to pharmacodynamics, drug-receptor interaction, body compartment systems, Drug Action Action and effect, Excitation and Inhibition, Selectivity of drug action, Therapeutic effect and adverse reaction, Principles of Drug action- Dose effect relationship, Time effect relationship, structure activity relationship,Mechanism of drug action- Simple physical and chemical property, involving or interfering physiological and biochemical process of living system.

Pre-requisites: Basic level biology and biochemistry

Total number of classes: 45

COURSE OBJECTIVES

• Be able to articulate the drug-intrinsic and extrinsic factors that determine drug molecule movement across biological membranes

• To demonstrate understanding in concepts that determine dosage, absorption, distribution, and excretions of drugs, along with model systems connected with these concepts and apply pharmacokinetic principles to explain variation in drug disposition

• To understand the basic concepts of drug delivery and physiochemical properties of the drug

• To demonstrate understanding of different routes of drug administration and different drug delivery systems.

• To understand basics of pharmacodynamics.

1. Robert E. Notari; Biopharmaceutics and Clinical Pharmacokinetics: An Introduction, Fourth Edition, 2017
2. Leon Shargel, Susanna Wu-Pong, Andrew Yu; Applied Biopharmaceutics & Pharmacokinetics 5thedition, McGraw-Hill Medical 2004
3. Rowland and Tozer, Clinical Pharmacokinetics: Concepts and Applications, 1995.
4. Drug Delivery: Fundamentals and Applications, Second Edition, CRC Press 2017.
5. Drug Delivery Systems, Pieter Stroeve and Morteza Mahmoudi, World Scientific Series: From Biomaterials towards Medical Devices, Vol I, 2018.
6. Rosenbaum SE, editor. Basic pharmacokinetics and pharmacodynamics: An integrated textbook and computer simulations. John Wiley & Sons; 2016.