Back close
Admissions

Course Detail

Course Name Organoids And Organs-On- Chips
Course Code 24MM731
Program M. Tech. in Molecular Medicine(MLM)
Semester 3
Credits 2
Campus Kochi

Syllabus

Preamble

The objective of this course is to familiarize students with the state-of-the art in vitro model systems that have the potential to mimic the normal and diseased human tissues and organs for biomedical research and development

Unit 1

In vitro model systems in medicine; basic concepts in developing in vitro models, biofabrication strategies for developing in vitro models, impact of in vitro models in disease modeling and drug testing, basics in 3D cell culture

Unit 2

Microfluidic cell culture systems; Introduction to microfluidic systems, the design concept and key components, fundamentals of organs-on-chips as in vitro microphysiological systems, applications of organs-on-chips in disease modelling, and safety and efficacy testing

Unit 3

Organoids; Basics of organoid development, experimental strategies, essential reagents and choice of 3D matrices, characterization of organoids, technical challenges.

Unit 4

3D Bioprinting in organoid development; Basics and importance of 3D printing of living cells for medical applications, choice of bio-inks, current advances and challenges in 3D bioprinting.

Unit 5

Organoids as in vitro model systems; cerebral organoids, liver organoids, intestinal organoids, pancreas and salivary gland organoids. Applications of organoids in cancer research, drug development and testing

Objectives and Outcomes

Pre-requisites: Undergraduate level basic biology, biotechnology and medical science

Total number of classes: 30

Course Outcome

CO1 Understanding on the different types of in vitro model systems and their advantages over conventional 2D cell culture systems

CO2 Understanding on the basic principles and components of microfluidics-based in vitro model systems

CO3 Understanding on the basic principles and components of organs-on-chips based in vitro model systems

CO4 Understanding on organoid development procedure, organoid types, advantages and challenges

CO5 Understanding on the working principle and components of 3D bioprinting and its applications

CO6 Understanding on the latest approaches and protocols used for developing various types of organoids for modeling diseases and drug testing.

Program Outcome

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – No Affinity

C

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

C O

CO 1

1

1

3

1

2

–

–

–

–

–

2

CO 2

–

1

3

1

2

–

–

–

–

–

2

CO 3

–

1

3

1

2

–

–

–

–

–

–

2

CO 4

3

1

3

1

2

2

–

2

–

–

–

2

CO5

1

1

3

1

2

–

–

–

–

1

–

2

CO6

2

1

3

1

2

2

–

1

–

1

–

2

 

Program Specific Outcomes. (PSO)

PSO 1 – Biochemical organization and cellular complexity in function

PSO 2 – Biomolecules in Medicine

PSO 3 – Molecular basis of disease

PSO 4 – Molecular technology in diagnosis and therapy

PSO 5 – Cellular based approaches in diagnosis and therapy

PSO 6 – Microorganisms in Medicine

PSO 7 – Nanoscale entities and its significance in Medicine

PSO 8 – Tissue architecture engineering in Medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and biological data use

C

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

C O

CO 1

–

1

–

–

3

–

–

2

–

–

CO 2

–

–

–

–

3

–

–

2

–

–

CO 3

–

–

–

–

3

–

–

2

–

–

CO 4

2

2

–

2

3

–

1

3

3

–

CO5

–

–

–

–

3

–

1

3

–

–

CO6

2

2

3

2

3

–

1

3

3

–

Evaluation Pattern

Internal Assessment – 50% 

Periodical 1 

Exam 

20% 

Periodical 2 

Exam 

20% 

Continuous Assessment 

Assignment/Test/Quiz

10% 
   

50%

End Semester Examination- 50% 

Theory Exam 

50% 
   

50%
 

Total

100%

Text Books / References

  1. Microfluidics: Fundamentals, Devices, and Applications, Wiley, 2018
  2. Organ-on-a-chip, Engineered Microenvironments for Safety and Efficacy Testing, Academic Press, 2018
  3. Jamie Davies and Melanie Lawrence, Organoids and Mini Organs, Academic Press, 2018

DISCLAIMER: The appearance of external links on this web site does not constitute endorsement by the School of Biotechnology/Amrita Vishwa Vidyapeetham or the information, products or services contained therein. For other than authorized activities, the Amrita Vishwa Vidyapeetham does not exercise any editorial control over the information you may find at these locations. These links are provided consistent with the stated purpose of this web site.

Admissions Apply Now