Unit 1
Biologic and Molecular Basis for Regenerative Medicine:Current perspectives in Regenerative Medicine; Types of Tissues; Molecular organisation of cells; Extracellular Matrix; Cell-extracellular matrix interactions
| Course Name | Regenerative Medicine & Tissue Engineering |
| Course Code | 24MMD543 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Kochi |
Biologic and Molecular Basis for Regenerative Medicine:Current perspectives in Regenerative Medicine; Types of Tissues; Molecular organisation of cells; Extracellular Matrix; Cell-extracellular matrix interactions
Cellular aspect of Regenerative Medicine: Stem cells and progenitors; Types of stem cells, Embryonic stem cells, induced pluripotent stem cells, Mesenchymal stem cells, Hematopoietic stem cells, Adult stem cells
Different Stages of Tissue Regeneration: Basic cell structure and functions; Tissue organisation and functions; Organ structure and functions, Scar and Regeneration; Different stages of regeneration – Hemostasis, Inflammation, Proliferation, Angiogenesis, Remodelling; Case studies – Skin regeneration, Bone regeneration, Liver regeneration.
Tissue Engineering: Relevance of tissue engineering; Triad of Tissue engineering – Scaffolds Types (Ceramics, Polymers, Composites Biomimetic scaffold); Cells, Growth factors; Case Studies: Ectoderm derived tissues (Nerve tissue, Cornea), Endoderm derived tissues (Liver, Pancreas), Mesoderm (Bone, Cartilage, Muscle, blood vessels, ligament, Tendon). Recent advances in biofabrication; 3D bioprinting
Pre-requisites: Undergraduate level basic physics, chemistry and biology
Total number of classes: 45
COURSE OUTCOMES:
Upon successful completion, students will have the
CO1. Understanding on the molecules and signalling pathways that regulate epithelial and mesenchymal states of tissues and cell-extracellular matrix interactions
CO2. Knowledge on the various types and sources of stem cells and their role in tissue growth, repair and regeneration
CO3. Knowledge on the inherent regenerative mechanisms in human body
CO4. Understanding on the fundamental aspects of tissue engineering and their application in developing various tissues.
Program Outcome
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity
| C | PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 |
| C O | ||||||||||||
| CO 1 | 3 | 1 | 1 | – | 1 | 1 | – | – | – | – | – | 2 |
| CO 2 | 3 | 1 | 1 | – | 1 | 1 | – | 3 | 1 | – | – | 2 |
| CO 3 | 3 | 1 | 2 | 3 | 1 | 1 | – | 1 | 1 | – | – | 2 |
| CO 4 | 3 | 1 | 3 | 3 | 3 | 1 | – | 1 | 1 | – | – | 2 |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular basis of disease
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cellular based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
| C | PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 |
| C O | ||||||||||
| CO 1 | 3 | 1 | – | – | 3 | – | 1 | 3 | – | – |
| CO 2 | – | 2 | – | – | 3 | – | – | 3 | – | – |
| CO 3 | 2 | 2 | – | – | 3 | – | – | 3 | – | – |
| CO 4 | 2 | 2 | – | – | 3 | – | 2 | 3 | 3 | – |
| Internal Assessment – 50% | ||
| Periodical 1 | Exam | 20% |
| Periodical 2 | Exam | 20% |
| Continuous Assessment | Assignment/Test/Quiz | 10% |
| 50% | ||
| End Semester Examination- 50% | ||
| Theory Exam | 50% | |
| 50% | ||
| Total | 100% |
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