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Course Detail

Course Name Molecular Basis of Diseases.
Course Code 24MMD541
Program M. Sc. Molecular Medicine(MLM)
Semester 2
Credits 3
Campus Kochi

Syllabus

Preamble

This course is primarily designed to help students understand the molecular mechanism behind disease processes. The idea is to use specific examples of disease conditions that are globally prevalent and effects large populations worldwide. These chosen diseases will be used to study and understand disease manifestation, progress, and outcome, based on molecular mechanisms at the tissue and cellular level. This course utilizes an active learning strategy where students and the instructor will discuss recent developments in molecular pathogenesis of the specific diseases, based on published articles.

Unit 1

Introduction to disease pathogenesis, clinical terminologies, concept of prognosis, evidence-based treatment approach, bench-to-bedside approach in medicine, and introduction to a holistic approach in treating diseases

Unit 2

The process of growth, differentiation and cell death and its molecular organization in cellular homeostasis and diseases such as cancer, neurodegenerative diseases and diabetes. Significance of molecular changes in controlling a normal homeostasis condition compared to disease.

Unit 3

Pathological changes in diseases such as cancer, neurodegenerative diseases, autoimmune diseases and diabetes. The role of molecules and molecular changes in the pathological manifestation of disease.

Unit 4

Significance of environmental chemicals in modifying normal homeostasis and leading to pathological changes at molecular level by controlling different signaling mechanisms. Significance of epidemiology, etiology in pathogenesis of diseases

Unit 5

Inflammation in normal and pathological state. Molecular mechanisms driving the immunopathology in cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Interdependence of molecular pathways in controlling homeostasis and disease pathology

Unit 6

How the molecular changes can be targeted to reverse the pathology and the contribution of drugs in this respect cancer, neurodegenerative diseases, autoimmune diseases and diabetes.

Unit 7

DNA modifications and mutations in diseases and its significance in the pathology associated with cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Role of environment in (lifestyle) in modifying DNA and the molecular landscape associated with homeostasis and disease in cancer, neurodegenerative diseases, autoimmune diseases and diabetes.

Objectives and Outcomes

Pre-requisites: Basic understanding of biology and biochemistry

Total number of classes: 45

Course Outcome

CO1: To demonstrate ability to approach a scientific report in a systematic manner

CO2: To be able to identify scientific hypothesis and understand the rationale behind the research approach in a scientific report

CO3: Be able to summarize disease pathogenesis and connect it to clinical signs and symptoms associated with the disease

CO4: Be able to work with team and put together in depth information related to disease mechanism at the cellular and molecular level, treatment options and current developments in the field

CO5: Be able to give a presentation related to molecular basis of a disease and field audience questions related to the topic

Programme Outcomes (PO) As given by NBA and ABET)

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12
CO1 2 3 1 3 3 3
CO2 1 3 1 2 3 3 3 3
CO3 3 2 1 3 3 3 3
CO4 2 3 3 2 3 3 2 3 3 1 3
CO5 1 1 3 2 1 2 3 3 3

 

Program Specific Outcomes. (PSO)

PSO 1 – Biochemical organization and cellular complexity in function

PSO 2 – Biomolecules in Medicine

PSO 3 – Molecular dysregulation in diseases

PSO 4 – Molecular technology in diagnosis and therapy

PSO 5 – Cell based approaches in diagnosis and therapy

PSO 6 – Microorganisms in Medicine

PSO 7 – Nanoscale entities and its significance in Medicine

PSO 8 – Tissue architecture engineering in Medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and biological data use

PSO1 PSO2 PSO3 PSO4 PSO5 PSO6 PSO7 PSO8 PSO9 PSO10
CO1 1 1
CO2 2 2 2 1 2
CO3 3 3 3 3 3 3 1 1 1
CO4 3 3 3 3 3 3 1 1 1
CO5 3 3 3 3 3 1 1 3

Evaluation Pattern

Internal Assessment – 50% 
Periodical 1  Exam 20%
Periodical 2  Exam 20%
Continuous Assessment  Assignment/Test/Quiz 10%
    50%
End Semester Examination- 50% 
Theory Exam 50%
  50%
  Total 100%

Text Books / References

Robbins Basic Pathology, 9th edition, Kumar, Abbas, Fausto and Mitchell; Saunders, Publication, ISBN-13: 978-1437717815. ]

Selected research articles will be provided before each class

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