| Course Name | Immunology |
| Course Code | 24MMD511 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Kochi |
This course is designed to provide a comprehensive understanding of both fundamental and applied aspects of immunology. Successful completion of this course will foster a deep appreciation for the dynamic and multifaceted field of immunology, equipping the students with the knowledge and skills essential for both academic exploration and practical applications in various domains of science and medicine.
Basic Concepts in Immunology, Cells and organs of the immune system, Principles of Innate and Adaptive Immunity
Innate Immunity: Recognition and effector mechanisms, Inflammation and its regulation, Complement system.
Adaptive Immunity: Antigen recognition and processing, B and T cell development and activation, Immune memory, Antigen Recognition by B-cell and T-cell Receptors
The Generation of Lymphocyte Antigen Receptors, the generation of diversity in immunoglobulins, T-cell receptor gene rearrangement, Structural variation in immunoglobulin constant regions.
The development and survival of Lymphocytes: Generation of lymphocytes in bone marrow and thymus, the rearrangement of antigen-receptor gene segments controls lymphocyte development, interaction with self-antigens selects some lymphocytes for survival but eliminates others, survival and maturation of lymphocytes in peripheral lymphoid tissues.
T cell-mediated immunity: Production of armed effector T cells, General properties of armed effector T cells, T cell-mediated cytotoxicity, Macrophage activation by armed CD4 TH1 cells.
Immunopathology: Autoimmunity, Allergy and hypersensitivity, Immunodeficiency disorders</p
Immunotherapy and Vaccines: Monoclonal Antibodies: Production and Applications, Adoptive Cell Therapy and Immunomodulation, Vaccine Development and Immunization Strategies, Currently available vaccines. Immunotherapy in Autoimmune Diseases and Cancer
Immunological Diagnostics: Serological Techniques: ELISA, Western Blotting, Flow Cytometry and Immunophenotyping, Molecular Diagnostics in Immunology, Point-of-Care Testing in Immunodiagnostics
Course Outcome
CO1 Knowledge about the microorganisms, basic skills in aseptic/sterilization techniques, antimicrobial agents and microbial diseases. Students will learn the composition of human microbiome and their role in maintaining normal gut function.
CO2 Will gain knowledge about principles of innate and adaptive immune system, the antigen receptor structure and the mechanisms of antigen recognition by B-cell and T-cells.
CO3 Gain knowledge about immune signal mechanisms, lymphocyte generation, B-and T-cell receptor gene rearrangements; and lymphocyte development.
CO4 Will gain knowledge about macrophage and B cell activation by T cells, adaptive Immunity to Infection: immunological memory. Failures of Host Defense Mechanisms, immunodeficiency diseases, acquired immune deficiency syndrome.
CO5 Gain knowledge about the mechanism of allergic responses, hypersensitivity reactions, autoimmunity and transplantation. The students will also learn about the importance for immunization and manipulation of the immune system to fight infectious disease.
Program Outcomes
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
| c | PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 |
| C O | ||||||||||||
| CO 1 | 3 | 1 | 1 | 1 | – | – | – | – | – | – | – | 1 |
| CO 2 | 3 | 1 | 1 | – | – | – | – | – | – | – | – | 1 |
| CO 3 | 3 | 1 | 1 | – | – | – | 1 | |||||
| CO 4 | 3 | 1 | 1 | 1 | – | – | – | – | – | – | – | 1 |
| CO 5 | 3 | 1 | 1 | 1 | 1 | – | – | – | – | – | – | 1 |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular basis of disease
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cellular based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
| – | PSO1 | PSO2 | PSO3 | PSO4 | PSO5 | PSO6 | PSO7 | PSO8 | PSO9 | PSO10 |
| C O | ||||||||||
| CO 1 | 3 | 1 | 2 | – | – | 3 | – | – | 1 | – |
| CO 2 | 3 | – | 1 | – | – | – | – | – | – | – |
| CO 3 | 3 | 1 | 1 | – | 1 | – | – | – | – | – |
| CO 4 | 3 | – | 1 | – | – | – | – | – | – | – |
| CO 5 | 3 | – | 3 | – | 2 | – | – | – | – | – |
| Internal Assessment – 50% | ||
| Periodical 1 | Exam | 20% |
| Periodical 2 | Exam | 20% |
| Continuous Assessment | Assignment/Test/Quiz | 10% |
| 50% | ||
| End Semester Examination- 50% | ||
| Theory Exam | 50% | |
| 50% | ||
| Total | 100% |
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