Unit 1
Overview of genetics: Relationship between genes and traits, Fields and science of genetics; Patterns of inheritance: Mendelian inheritance, Law of segregation, Law of independent assortment, Studying inheritance patterns in humans;
| Course Name | Genetics: Principles and Analysis |
| Course Code | 24MMD513 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Kochi |
Overview of genetics: Relationship between genes and traits, Fields and science of genetics; Patterns of inheritance: Mendelian inheritance, Law of segregation, Law of independent assortment, Studying inheritance patterns in humans;
Extensions of Mendelian inheritance: Overview of simple inheritance patterns, Dominant and recessive alleles, Environmental effects on gene expression, Incomplete dominance, overdominance and codominance, X-linked inheritance, Sex-influenced and sex-limited inheritance, Lethal alleles, Pleiotropy, Gene interactions, Non-Mendelian inheritance: Maternal effect, Epigenetic inheritance-dosage compensation and genomic imprinting, Extranuclear inheritance;
Chromosomes of eukaryotes: Chromosome organization and molecular structure: General features of chromosomes, Organization sites along eukaryotic chromosomes; Chromosome transmission during cell division and sexual reproduction: Chromosomes during cell divisions – mitosis and meiosis, The chromosome theory of inheritance and sex chromosomes; Genetic linkage and mapping in eukaryotes: Overview of linkage, Relationship between linkage and crossing over, Genetic mapping in animals, Mitotic recombination; Variation in chromosome structure and number: Changes in chromosome structure – an overview, Deletions and duplications, Inversions and translocations, Changes in chromosome number – an overview, Variation in number of chromosomes within a set and in the number of sets of chromosomes;
Gene regulation in eukaryotes: Epigenetics: Epigenetics and development, Paramutation, Epigenetics and environmental agents, Role of epigenetics in cancer; Noncoding RNAs: Overview, Effects of noncoding RNAs on chromatin structure, transcription, translation, mRNA degradation and RNA modifications, Noncoding RNAs in protein targeting and genome defense, Role of noncoding RNAs in human diseases;
#BBD0E0
Medical, immuno and developmental genetics: Medical genetics: Inheritance patterns of genetic diseases, Genetic basis of cancer, Personalized medicine; Immunogenetics: Genetics of V(D)J recombination and antibody diversity; Developmental genetics: Genetics of vertebrate development, differential gene expression and its role in development;
Population and evolutionary genetics: Genes in populations and the Hardy-Weinberg equation, Overview of microevolution, Natural selection, Genetic drift, Migration, Nonrandom mating, Sources of new genetic variation; Complex and quantitative traits: Overview of complex and quantitative traits, Polygenic inheritance, Heritability, Selective breeding; Evolutionary genetics: Origin of species, Phylogenetic trees, Molecular evolution.
Pre-requisites: Basic understanding of biology and genetics
Total number of classes: 45
Course Outcome
CO1 To understand patterns of inheritance and laws of heredity at molecular levels
CO2 To understand about chromosomes and their transmission during cell divisions, genetic linkage and mapping in Eukaryotes, variations in chromosome structure and number, and chromosome organization and molecular structure
CO3 To comprehend various modes of epigenetic regulation on gene expression in
Eukaryotes and roles of noncoding RNA in gene regulation
CO4 To learn about genetic principles underlying medical, immune and developmental aspects
CO5 To gather knowledge of complex and quantitative traits, polygenic
Inheritance, population genetics, phylogenic trees and molecular evolution
Program Outcomes (PO)(As given by NBA and ABET)
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
| c | PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 |
| C O | ||||||||||||
| CO 1 | 3 | 3 | 3 | 3 | 2 | 2 | 3 | 0 | 0 | 0 | 0 | 3 |
| CO 2 | 3 | 2 | 2 | 2 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 3 |
| CO 3 | 3 | 2 | 2 | 2 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 3 |
| CO 4 | 3 | 1 | 1 | 2 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 3 |
| CO 5 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 3 |
0 – No affinity; 1 – low affinity; 2 – Medium affinity; 3 – High affinity
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular dysregulation in diseases
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cell based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
| C | PSO1 | PSO2 | PSO3 | PSO4 | PSO5 | PSO6 | PSO7 | PSO8 | PSO9 | PSO10 |
| C O | ||||||||||
| CO 1 | 3 | 1 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 1 |
| CO 2 | 3 | 1 | 3 | 3 | 3 | 0 | 0 | 3 | 0 | 3 |
| CO 3 | 3 | 3 | 3 | 3 | 2 | 0 | 0 | 2 | 0 | 3 |
| CO 4 | 3 | 2 | 3 | 3 | 1 | 0 | 0 | 2 | 3 | 0 |
| CO 5 | 3 | 2 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 3 |
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Internal Assessment – 50% |
||
|
Periodical 1 |
Exam |
20% |
|
Periodical 2 |
Exam |
20% |
|
Continuous Assessment |
Assignment/Test/Quiz |
10% |
|
50% |
||
|
End Semester Examination- 50% |
||
|
Theory Exam |
50% |
|
|
50% |
||
|
Total |
100% |
Genetics: Analysis and Principles, 6th edition, Robert Brooker, McGraw-Hill Professional publishers, 2017.
Principles of genetics, 8th edition, Gardner, Simmons, Snustad, Wiley, 2006.
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