| Course Name | Molecular Biology |
| Course Code | 22MMD502 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 1 |
| Credits | 3 |
| Campuses | Faridabad, Kochi |
(Lectures 10)
DNA: Structure and function, Chromosome and chromatin, Genetic code, wobble hypothesis, RNA and types of RNA (rasiRNA, tasiRNA, nat-siRNA, piRNA), Proteins and their structure
(Lectures 10)
DNA replication and its regulation, Homologous and site-specific recombination, DNA repair
(Lectures 10)
Transcription and its regulation, Translation and its regulation, Gene structure, Repeats and clusters, Gene expression regulations: operon, Epigenetics
(Lectures 5)
Types of mutations, Genetic system of mitochondria
(Lectures 10)
Gene identification, promoter identification, Molecular biology techniques: Isolation and
Quantification of DNA/RNA, PCR, Reverse transcriptase PCR, Real Time PCR, DNA
Sequence analysis, hybridization (southern, northern and western) and Sanger sequencing.
Pre-requisites: Undergraduate level basic DNA biology
Total number of classes: 45
Preamble
This course will provide a thorough understanding about biology of DNA, its functional significance and how it is very much involved in the biochemistry and physiology of the cell.
CO1 Understand the structure and function of DNA, RNA and proteins
CO2 Understand the basics of DNA and RNA replication, transcription, translation and DNA-repair systems
CO3 Understand how genetic switches work, the basics of gene regulation in prokaryotes and eukaryotes
CO4 Understand the consequences of different types of mutations and recombinations
CO5 Understand basic and advanced molecular biology concepts and techniques
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
| C/CO | PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 |
| CO1 | 3 | 1 | 2 | |||||||||
| CO2 | 3 | 1 | 1 | 1 | ||||||||
| CO3 | 3 | 2 | 1 | 2 | 2 | 1 | 1 | |||||
| CO4 | 3 | 3 | 1 | 2 | 2 | 2 | ||||||
| CO5 | 3 | 1 | 2 | 1 | 3 | 2 | 1 |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular basis of disease
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cellular based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
| C/CO | PSO1 | PSO2 | PSO3 | PSO4 | PSO5 | PSO6 | PSO7 | PSO8 | PSO9 | PSO10 |
| CO1 | 3 | 2 | 1 | 1 | 1 | |||||
| CO2 | 3 | 2 | 1 | 1 | 1 | |||||
| CO3 | 3 | 2 | 3 | 1 | 1 | |||||
| CO4 | 3 | 3 | 3 | 1 | 1 | 2 | ||||
| CO5 | 2 | 3 | 2 | 2 | 3 |
Evaluation Pattern: 50+50 = 100
| Internal Assessment – 50% | ||
| Periodical 1 | Exam | 20% |
| Periodical 2 | Exam | 20% |
| Continuous Assessment | Assignment/ Test/ Quiz | 10% |
| 50% | ||
| End Semester Examination- 50% | ||
| Theory Exam | 50% | |
| 50% | ||
| Total | 100% | |
Textbook
References
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