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Course Detail

Course Name Medical Microbiology & Immunology
Course Code 24AIM447
Program B.Tech. Artificial Intelligence (AI) and Data Science (Medical Engineering)
Semester VII
Credits 3
Campus Coimbatore

Syllabus

Microbiology and pathology

i) History of microbiology, General Pathology – history and principles of pathology, Microscopic pathology Bacterial and Viral Pathology – i) General structure of bacteria and virus ii) Mechanism of bacterial and viral pathogenesis – an overview iii) Bacterial pathogens and the diseases – Staphylococcus, Streptococcus, Neisseria, Enterobacteriaceae (Escherichia, Klebsiella, Enterobacter, Proteus, Salmonella and Shigella). Campylobacter, Helicobacter. Vibro cholera, Clostridia (spore-forming anaerobic bacteria), Pseudomonas, Mycobacteria. Brucella, Hemophilus species, Treponema, Leptospira, Legionella, Chlamydia and mycoplasmas iv) Basic Pathogenesis of specific virus families’ relevance to human diseases – Coronaviridae, Adenoviridae, Hepadnaviridae, Herpesviridae, Reoviridae, Retorviridae, Orthomyxoviridae, Paramyxoviridae, Papillomaviridae, Picornaviridae & Togaviridae Fungal Pathology – i) classification, structure, and function of fungi, fungal pathogenesis, and the host response to fungal infections, including aspergillosis, candidiasis, and cryptococcosis. Parasitic Pathology – i) classification, parasitic pathogenesis, and the host response to parasitic infections. Major medically important protozoa and associate diseases – Leishmania, Plasmodium malaria, Toxoplasma gondii, Trichomonas vaginalis, Trypanosomes, Entamobea histolytica. ii) Emerging Infectious Diseases: recent advances in the understanding of newly emerging infectious diseases, including SARS, MERS, and COVID-19.

Immunology/Immuno-pathology

i) Introduction to Immunology, structure and function of Immune system ii) Innate Immunity: Toll-like receptors, complement system, phagocytosis. iii) Acquired Immunity: T and B cell immunity, humoral and cell-mediated immunity, antibody structure and function. Passive Immunity and immune evasion strategies. iv) Antigens and Antigen Presentation: antigen processing and presentation, Major Histocompatibility Complex (MHC) molecules, T cell receptor (TCR) structure and function. General structure of antibodies, antigen- antibody reactions. v) Immune Tolerance: central and peripheral tolerance, self-tolerance mechanisms, regulatory T cells. vi) Immunological Disorders: autoimmune diseases, immune-deficiencies and allergies – including mechanisms of allergy, type 1 hypersensitivity reactions, atopic diseases and food allergies. vii) Vaccines: Types of vaccines, vaccine development and production, vaccine efficacy and safety. viii) Immunotherapy – cancer and infectious diseases. Immunotherapy in combination with chemotherapy, radiation therapy or targeted therapy. ix) Transplantation Immunology: mechanisms of transplant rejection, tolerance induction, and immunosuppression.

Course Objectives and Outcomes

Course Objectives:

  • The objective of the course is to familiarize the students with microorganisms and viruses, their structures, diseases caused by bacteria and viruses and their control.
  • Another objective is to introduce and elaborate upon the various aspects and mechanisms of immunity

Course Outcomes:

After completing this course, students should be able to
CO1: Understand the basic microbial & viral structure and function and comparative characteristics of prokaryotes and eukaryotes.
CO2: Understand the processes in microorganisms and viruses for their replication, survival, and interaction with their environment, hosts, and host populations
CO3: Understand fundamentals of microbe/viral interaction with humans leading to pathological effects

CO-PO mapping

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References

  1. Microbiology: An introduction, G.J. Tortora, B.R. Funke, C.L. Case, 5th Edition, Benjamin Pub. Co. NY, 1992.
  2. Medical Bacteriology, N.C. Dey, and T. K. Dey, Allied Agency, Calcutta, 17th Edition, 1988.
  3. Text book of microbiology, R. Ananthnarayana, and C.E, Jayaram Panikar, 5th edition, Orient Longman, 1996.
  4.  Fields Virology D. Knipe and P. Howley. Vol.1 and 2- 4 th Edition. Lippincott-Raven Publishers, 2006. 5) Fundamentals of Molecular Virology, N. H. Acheson 2nd Edition. Wiley Publisher, 2011.
  5. Title: Medical Microbiology. Authors – Patrick R. Murray, Ken S. Rosenthal, and Michael A. Pfaller. 9th edition, 2020, Publisher – Elsevier. ISBN – 9780323673228.
  6. Title: Medical Microbiology. Authors – David Greenwood, Richard CD., Slack, John Forrest Peutherer. 16th edition,1992. ELBS with Churchill Livingstone.
  7. Title: Clinical Immunology: Principles and Practice. Authors – Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Henry M. Lederman, Michael F. Fanger, and Annette L. Baumeister. 3rd edition, 2018. Publisher – Elsevier. ISBN: 9780323552071.
  8. Title: Kuby Immunology. Authors: Judy Owen, Jenni Punt, and Sharon Stranford. 8th edition, 2018; Publisher: W. H. Freeman and Company. ISBN: 978-1319114701.
  9. Title: Underwood’s Pathology: A Clinical Approach. Author: Simon Cross. Edition: 6th, 2017; Publisher: Churchill Livingstone. ISBN: 9780702051348
  10. Title: Rapid Review Pathology. Author: Edward F. Goljan. 4th edition, 2019. Publisher: Elsevier. ISBN: 9780323528707

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