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Course Detail

Course Name Regenerative Medicine
Course Code 24MMD303
Program B. Sc. Honors (with Research) in Molecular Medicine
Semester 5
Credits 3
Campus Kochi

Syllabus

Preamble

This course introduces the student to the fundamentals of regenerative medicine. The central focus of this course is to help the students to get familiarise with the inherent regenerative mechanisms in the human body and various approaches that are currently utilized for improving tissue repair and regeneration.

Unit 1

Molecular organization of cells: Molecules that organize cells, Cell-cell adhesion, Changes in cell–cell adhesion, Cell interaction with the basal lamina, Cell polarity, Changes in cell polarity during cell transition, The epithelial–mesenchymal transition, Molecular control of the epithelial–mesenchymal transition. Signaling pathways is animal development and regeneration, Notch signaling, Wnt/β-catenin signaling

Unit 2

Cell–extracellular matrix interactions in repair and regeneration: Extracellular matrix composition and diversity, Receptors for extracellular matrix molecules, Signal transduction events during cell–extracellular matrix interaction, Cell–extracellular matrix interactions during healing process.

Unit 3

The Biology function and biomedical applications of exosomes: Biogenesis of exosomes, Heterogeneity in exosomes, Intracellular communication, Diagnostic potential of exosomes, Exosomes in regenerative applications.

Unit 4

Wound repair and regeneration: Molecular pathology of chronic wounds, Molecular and cellular mechanisms in normal skin repair and wound healing, Scarring and tissue fibrosis, Diabetic wounds, Current treatments and their limitations in wound healing.

Unit 5

Stem cells in regenerative medicine. Stem cell types, Stem isolation and expansion, characterisation, Cell therapy in regenerative medicine, Tissue engineering, Applications of engineered tissues in regenerative medicine.

Objectives and Outcomes

Course Outcomes

Upon successful completion, students will have the

CO1. Understanding on the cell-cell and cell-extracellular matrix interactions that regulate tissue development and regeneration

CO2. Understanding on the extracellular matrix and its role in regenerative medicine

CO3. Understanding on exosomes and their role in inter and intra cellular communications and applications in regenerative medicine

CO4. Knowledge on the inherent regenerative mechanisms in human body with specific emphasis on wound healing

CO5. Knowledge on the various types and sources of stem cells and their role in tissue growth, repair and regeneration

Program Outcomes

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

c

C O

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

CO 1

3

–

–

2

2

–

–

–

1

–

–

3

CO 2

3

2

–

2

2

–

–

–

1

–

–

3

CO 3

3

1

2

3

1

–

–

1

1

–

–

3

CO 4

3

1

2

3

2

–

–

1

1

–

–

3

CO 5

3

1

2

3

2

1

–

2

1

–

–

3

 

Program Specific Outcomes. (PSO)

PSO 1 – Chemical and physical basis of biology

PSO 2 – Computational science in biology and medicine

PSO 3 – Biochemical and physiological complexity in biology and medicine

PSO 4 – Molecular technology in biology and medicine

PSO 5 – Cell based approaches in diagnosis and therapy

PSO 6 – Microorganisms in medicine

PSO 7 – Nanoscale entities and its significance in medicine

PSO 8 – Tissue architecture engineering in medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and artificial intelligence in medicine

PSO 11 –Technology in personalizing medicine

PSO 12 – Protein structural complexity in medicine

PSO 13 – Projecting science and medicine to public

c

C O

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

PO13

CO 1

2

–

1

–

3

–

1

3

–

–

2

–

–

CO 2

1

–

1

–

1

–

1

3

–

–

2

–

–

CO 3

1

–

–

–

1

–

3

–

2

–

2

–

–

CO 4

2

–

3

–

3

–

1

3

1

–

2

–

–

CO 5

–

–

1

–

3

–

–

3

–

–

2

–

–

Evaluation Pattern

Internal Assessment – 50% 

Periodical 1 

Exam 

20% 

Periodical 2 

Exam 

20% 

Continuous Assessment 

Assignment/Test/Quiz

10% 

50%

End Semester Examination- 50% 

Theory Exam 

50% 

50%

Total

100%

Text Books / References

  1. Principles of Regenerative MedicineBook, 3rd Edition; 2019 edited by Anthony Atala, Robert Lanza, Antonios G. Mikos&Robert Nerem.
  2. Essentials of Stem Cell Biology, Second Edition, 2009, Edited by Robert Lanza, M.D.,ISBN: 978-0-12-374729-7, Elsevier Inc.

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