| Course Name | Post-translational modifications in Biology and Medicine |
| Course Code | 24MMD332 |
| Program | B. Sc. Honors (with Research) in Molecular Medicine |
| Semester | 5 |
| Credits | 3 |
| Campus | Kochi |
Post translational modification is a key event that impart different functions to proteins. These modifications play a major role in many diseases and are target for therapy. Thus, identification, understanding and targeting it for therapy has huge applications in medicine.
What are post translational modifications and how many different types of these modifications exists and its significance in biology and medicine. What is the purpose of post translational modifications. What are phosphorylation, glycosylation, neddylation, ubiquitinylation, sumoylation, acetylation, deamidation, sulfation including oxidation.
What is phosphorylation and its biological and medical significance. Role of phosphorylation in the function of those biological macromolecules such as proteins or lipids. How the addition/removal of functional groups in drastic alterations in protein function.
What is glycosylation. What are glycoproteins and glycolipids and their significance in biology and medicine. Why they are part of many receptors and its role in function of those proteins. Use of it as biomarkers in many diseases.
Significance of ubiquitinylation, sumoylation, acetylation, deamidation, sulfation including oxidation. Their significance in biology and its applications in medicine. PTM Characterization and its modification patterns in biopharmaceutical development and production.
Post-Translational Modification in Drug Design, enzyme function and drug binding affinity. Conformational changes and its role in protein function and diseases. Impact of post-Translational modification on biotherapeutic formulation.
Course Outcomes
CO1 To understand the basic concept of post-translational modifications, protein properties and its significance in biology
CO2 To understand the different types of post-translational modifications and its significance
CO3 Protein structure function understanding and its importance
CO4 Significance of post-translational modifications drug development and therapy
CO5 Role of post-translational modifications in diseases
Program Outcome
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
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c C O |
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
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CO 1 |
3 |
3 |
3 |
3 |
2 |
2 |
– |
– |
1 |
– |
– |
2 |
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CO 2 |
3 |
3 |
3 |
3 |
2 |
– |
– |
– |
1 |
– |
– |
2 |
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CO 3 |
3 |
3 |
3 |
3 |
2 |
– |
– |
– |
– |
– |
– |
1 |
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CO 4 |
3 |
3 |
3 |
3 |
2 |
1 |
– |
– |
2 |
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CO 5 |
3 |
3 |
3 |
3 |
2 |
2 |
1 |
– |
– |
– |
– |
1 |
Program Specific Outcomes.
PSO 1 – Chemical and physical basis of biology
PSO 2 – Computational science in biology and medicine
PSO 3 – Biochemical and physiological complexity in biology and medicine
PSO 4 – Molecular technology in biology and medicine
PSO 5 – Cell based approaches in diagnosis and therapy
PSO 6 – Microorganisms in medicine
PSO 7 – Nanoscale entities and its significance in medicine
PSO 8 – Tissue architecture engineering in medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and artificial intelligence in medicine
PSO 11 –Technology in personalizing medicine
PSO 12 – Protein structural complexity in medicine
PSO 13 – Projecting science and medicine to public
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– C O |
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
PSO7 |
PSO8 |
PSO9 |
PSO10 |
PSO11 |
PSO12 |
PSO13 |
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CO 1 |
3 |
1 |
3 |
3 |
3 |
– |
– |
– |
3 |
2 |
2 |
3 |
2 |
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CO 2 |
3 |
2 |
3 |
2 |
3 |
– |
– |
– |
3 |
2 |
1 |
3 |
1 |
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CO 3 |
3 |
3 |
3 |
2 |
3 |
– |
– |
– |
3 |
2 |
2 |
3 |
2 |
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CO 4 |
3 |
3 |
3 |
3 |
3 |
– |
– |
– |
3 |
3 |
3 |
3 |
2 |
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CO 5 |
3 |
1 |
3 |
3 |
3 |
– |
– |
– |
3 |
2 |
2 |
3 |
3 |
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