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Course Detail

Course Name Molecular Genetics and Personalized Medicine
Course Code 24MMD301
Program B. Sc. Honors (with Research) in Molecular Medicine
Semester 5
Credits 3
Campus Kochi

Syllabus

Preamble

The course on genetics is to provide clarity on the elements of heredity and variation existing in nature. Mendel’s experiments, laws of heredity, extensions and deviations of Mendelism, structural and numerical alterations found in chromosomes, generation of transgenic animals for the study of genetics will be taught in detail. In the later part of the course, emphasis is given to human genetics to make the students understand genetic basis of heredity, disease and personalized medicine.

Unit 1

Elements of heredity and variation: Mendel and his experiments; Principles of segregation and independent assortment and their chromosomal basis; Test cross; Application of laws of probability to Mendelian inheritance

Unit 2

Extension of Mendelism: Dominance relationships (complete dominance, incomplete dominance and co-dominance); Multiple allelism; Lethal alleles; Pleiotropy; Epistasis; Penetrance and expressivity; Phenocopy; Polygenic inheritance.

Unit 3

Cytoplasmic and infective inheritance; Linkage: Linkage and crossing over; Structural and numerical alterations of chromosomes; Transgenic animals: strategies and applications

Unit 4

Introduction: What Is in a Human Genome? Meiosis, Development and Aging.

Unit 5

Transmission Genetics: Single-Gene Inheritance; Beyond Mendel’sLaws; Matters of Sex; Multifactorial Traits; Genetics of Behavior.

Unit 6

Genes and Regulation: Gene Expression and Epigenetics; Gene Mutation; Chromosomes

Unit 7

Population Genetics: Constant Allele Frequencies and DNA Forensics; Changing Allele Frequencies; Human genome project and, human ancestry and Evolution.

Unit 8

Genetics of Personalized Medicine: Use of subtle genetic variations in personalized medicine, Next-generation-sequencing (NGS) and use of omics in personalized medicine, Pharmacogenomics in personalized medicine, Approaches to develop personalized medicine.

Objectives and Outcomes

Course Outcome

CO1 To understand the elements of heredity and variation existing in nature and the laws of heredity

CO2 To learn about genes, alleles and types of associations between the alleles, and alleles and inheritance patterns

CO3 To know about cytoplasmic and infective inheritance, linkage, linkage mapping, and strategies employed in the production of transgenic animals and application potential of transgenics

CO4 To learn about human genome, meiosis, genetics of development and aging, transmission genetics and pharmacogenetic

CO5 To learn about genes and regulation, population genetics, personalized medicine, human ancestry and evolution

Program Outcome

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9:  Individual & Team work

PO10:  Communication

PO11:  Project management & Finance

PO12:  Lifelong learning

c

C O

PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12
CO 1 3 3 2 2 3 3 3 3
CO 2 3 3 2 2 3 3 3 3
CO 3 3 3 2 2 3 3 3 3
CO 4 3 3 2 2 3 3 3 3
CO 5 3 3 2 2 3 3 3 3

 

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

Program Specific Outcomes (PSO)

PSO 1 – Chemical and physical basis of biology

PSO 2 – Computational science in biology and medicine

PSO 3 – Biochemical and physiological complexity in biology and medicine

PSO 4 – Molecular technology in biology and medicine

PSO 5 – Cell based approaches in diagnosis and therapy

PSO 6 – Microorganisms in medicine

PSO 7 – Nanoscale entities and its significance in medicine

PSO 8 – Tissue architecture engineering in medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and artificial intelligence in medicine

PSO 11 –Technology in personalizing medicine

PSO 12 – Protein structural complexity in medicine

PSO 13 – Projecting science and medicine to public

C O

PSO1 PSO2 PSO3 PSO4 PSO5 PSO6 PSO7 PSO8 PSO9 PSO10 PSO11 PSO12 PSO13
CO 1 3 1 3 3 2 2 1 1 2 3
CO 2 3 1 3 3 2 2 1 1 2 3
CO 3 3 1 3 3 2 2 1 1 2 3
CO 4 3 1 3 3 2 2 1 1 2 3
CO 5 3 1 3 3 2 2 1 1 2 3

Evaluation Pattern

Internal Assessment – 50%
Periodical 1 Exam 20%
Periodical 2 Exam 20%
Continuous Assessment Assignment/Test/Quiz 10%
50%
End Semester Examination- 50%
Theory Exam 50%
50%
Total 100%

Text Books / References

(1) Gardner et al: Principles of Genetics (1991, John Wiley).

(2) Ricki Lewis: Human Genetics (12th edition, McGraw Hill).

(3) Genomic and Precision Medicine: Foundations, Translation, and Implementation (2016); by Geoffrey S. Ginsburg (Editor), Huntington F Willard.

(4) Personalizing Precision Medicine: A Global Voyage from Vision to Reality Author: Kristin ciriello Pothier (2017) by Wiley.

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