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Course Detail

Course Name Metabolism in Diseases
Course Code 24MMD213
Program B. Sc. Honors (with Research) in Molecular Medicine
Semester 4
Credits 2
Campus Kochi

Syllabus

Preamble

Existence of cells require energy and nutrients towards maintenance and homeostasis. Thus, production of energy is vital for every function a cell execute. The question is, how effectively the cell achieves this task and what mechanisms at play and the role of various enzymes in this process. Enzymes are the key components responsible for the vital chemical rearrangements and modifications of various biological molecules carried out at 37ºC with utmost specificity. These changes are responsible for various communications and modifications that happens as a result of environmental and internal cues a cell receives essential for the production of energy and various other metabolites critical for maintaining the cell structure function

Unit 1

Significance of six carbon sugar glucose in cellular homeostasis. 

Unit 2

Breakdown of glucose in energy production. Glycolysis, Tricarboxylic acid cycle, pentose phosphate pathway and how they are connected together with energy production and growth. Mitochondrial structure and its significance in the oxidative phosphorylation leading to energy production. Significance of this metabolism in disease

Unit 3

What are Lipids, Lipid composition and significance, Lipid metabolism: lipid synthesis and degradation

Unit 4

Oligosaccharides, different types of oligosaccharides, their synthesis and significance in biology.

Unit 5

Gluconeogenesis and its connection with the pentose phosphate pathway, metabolism of other important sugars (fructose metabolism and glycogen metabolism), glycogenesis, glycogenolysis, regulation of glycogen metabolism.

Objectives and Outcomes

CO1 Understanding the fundamentals of biochemistry and its dependency to oxygen and carbohydrates from external environment.

CO2 Student will understand the assimilation and breakdown of glucose for energy and essential metabolic components required for cell survival and growth.

CO3 Significance of glycolysis and tricarboxylic acid cycle in maintaining homeostasis and in diseases such as cancer.

CO4 Significance of pentose phosphate pathway in the context of glycolysis and tricarboxylic acid cycle and its involvement in growth and survival.

CO5 How glucose is generated and stored in the presence of plenty of metabolites belonging to glycolysis and pentose phosphate pathway.

 Program Outcomes (PO) (As given by NBA and ABET)

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

c

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

C O

CO 1

3

1

–

–

–

1

2

1

–

–

–

3

CO 2

3

1

–

–

1

1

–

–

–

–

–

3

CO 3

3

2

1

1

2

1

–

–

–

–

–

2

CO 4

3

1

–

1

–

1

–

–

–

–

–

1

CO 5

3

1

–

1

–

–

–

–

–

–

–

1

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

Program Specific Outcomes. (PSO)

PSO 1 – Chemical and physical basis of biology

PSO 2 – Computational science in biology and medicine

PSO 3 – Biochemical and physiological complexity in biology and medicine

PSO 4 – Molecular technology in biology and medicine

PSO 5 – Cell based approaches in diagnosis and therapy

PSO 6 – Microorganisms in medicine

PSO 7 – Nanoscale entities and its significance in medicine

PSO 8 – Tissue architecture engineering in medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and artificial intelligence in medicine

PSO 11 -Technology in personalizing medicine 

PSO 12 – Protein structural complexity in medicine

PSO 13 – Projecting science and medicine to public

–

PSO1

PSO2

PSO3

PSO4

PSO5

PSO6

PSO7

PSO8

PSO9

PSO10

PSO11

PSO12

PSO13

CO

CO1

3

–

2

–

–

–

–

–

–

–

–

–

1

CO 2

3

–

2

–

–

–

–

–

–

–

–

–

1

CO 3

1

–

3

–

–

–

–

–

–

–

–

–

1

CO 4

2

–

3

–

–

–

–

–

–

–

–

–

1

CO 5

2

–

2

–

–

–

–

–

–

–

–

–

2

Evaluation Pattern

Internal Assessment – 50% 

Periodical 1 

Exam 

20% 

Periodical 2 

Exam 

20% 

Continuous Assessment 

Assignment/Test/Quiz

10% 

50%

End Semester Examination- 50% 

Theory Exam 

50% 

50%

Total

100%

Text Books / References

  • Lehninger Principles of Biochemistry by David L. Nelson; Michael M. Cox, Freeman publications; Seventh Edition 2017.

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