Course

Unit 1

Fundamental concepts of drug delivery: Physicochemical Properties of Drugs, Effects of fundamental physicochemical properties on the biopharmaceutical behavior of drugs, Introduction to pharmacokinetics and pharmacodynamics – concept of ADME, Concentration-time curve of pharmacokinetics; Fundamentals of controlled drug delivery, Pharmacokinetic and pharmacodynamic basis of controlled drug delivery, Physicochemical and biological factors influencing design and performance of controlled release products.

Unit 2

Routes of Drug Delivery: Enteral – Oral, Sublingual, Buccal, Rectal; Parenteral – Intravenous, Intramuscular, Intra-arterial, Intra-thecal, Intradermal; Topical – Transdermal, Intranasal, Conjuctival; Conventional drug delivery systems; Concept of active and passive targeting of drugs – Drug Delivery to Tumors as an Example; Protein and Peptide Delivery; Vaccine delivery

Unit 3

Nanotechnology in Drug Delivery: Nanoscale Drug Delivery Systems – Advantages of nanodrug delivery – Improvements in pharmacokinetics, bioavailability, biodistribution;

Scaffolds and hydrogels in drug delivery: Applications of drug delivery systems in tissue engineering and regenerative medicine area.

1. Drug Delivery: Fundamentals and Applications, Second Edition, CRC Press 2017. n
2. Drug Delivery Systems, Pieter Stroeve and MortezaMahmoudi, World Scientific Series: From Biomaterials towards Medical Devices, Vol I, 2018.
3. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, First edition 1997 (reprint in 2001).
4. Nanoparticulates as Drug Carriers, Vladimir Torchillin, Imperial College Press, 2006