| Course Name | Chemistry-1 |
| Course Code | 24CHY106 |
| Semester | 1 |
| Credits | 2 |
| Campus | Kochi |
This course deals with the basic introduction to organic chemistry emphasizing its significance in biology and its integral nature with biochemistry, the chemistry of living organisms. Focusing primarily on the basic principles to understand the structure and reactivity of organic molecules, emphasis is on substitution, elimination, alkanes, alkenes, alkynes and their related reactions, understanding of different reaction mechanism and methods used for organic compound preparation.
Physical Effects, Electronic Displacements: Inductive Effect, Electromeric Effect, Resonance and Hyperconjugation
Cleavage of Bonds: Homolysis and Heterolysis.Structure, shape and reactivity of organic molecules: Nucleophiles and electrophiles.
Reactive Intermediates: Carbocations, Carbanions and free radicals. Strength of organic acids and bases: Comparative study with emphasis on factors affecting pK values.
Aromaticity: Benzenoids and Hückel’s rule. Aliphatic Hydrocarbons: Functional group approach for the following reactions ( preparations and reactions ) be studied in context to their structure.
Alkanes: Preparation: Catalytic hydrogenation, Wurtz reaction, Kolbe’s synthesis and, from Grignard reagent. Reactions: Free radical Substitution: Halogenation.
Alkenes: Preparation: Elimination reactions: Dehydration of alcohols and dehydrohalogenation of alkyl halides ( Saytzeff’s rule) cis alkenes ( Partial catalytic hydrogenation ) and trans alkenes ( Birch reduction ). Reactions: cis-addition ( alk. KMnO4 ) and trans-addition ( bromine ), Addition of HX ( Markownikoff’s and anti-Markownikoff’s addition), Hydration, Ozonolysis, oxymercuration-demercuration, Hydroboration-oxidation
Alkynes: Preparation: Acetylene from CaC2 and conversion into higher alkynes; by dehalogenation of tetra halides and dehydrohalogenation of vicinal-dihalides.Reactions: Formation of metal acetylides, addition of bromine and alkaline KMnO4, ozonolysis and oxidation with hot alk. KMnO4.
Course Outcome
CO1 – To understand the basic concepts of organic reaction mechanism and its intermediates.
CO2 – To learn the concepts of aromaticity, non-aromaticity and antiaromaticity.
CO3 – To learn the preparation and specific reactions of alkanes.
CO4 – To learn the preparation and specific reactions of alkenes
CO5 – To learn the preparation and specific reactions of alkenes
Program Outcome
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
| – | PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 |
| C O | ||||||||||||
| CO 1 | – | 3 | – | 1 | – | – | – | – | – | – | 1 | 1 |
| CO 2 | – | 2 | 3 | 1 | – | – | – | – | – | – | 1 | – |
| CO 3 | – | 1 | 3 | 1 | – | – | – | – | – | – | 1 | – |
| CO 4 | – | 1 | 3 | 1 | – | – | – | – | – | – | 1 | – |
| CO 5 | – | 1 | 3 | 1 | – | – | – | – | – | – | 1 | – |
Program Specific Outcomes ( PSO )
PSO 1 – Chemical and physical basis of biology
PSO 2 – Computational science in biology and medicine
PSO 3 – Biochemical and physiological complexity in biology and medicine
PSO 4 – Molecular technology in biology and medicine
PSO 5 – Cell based approaches in diagnosis and therapy
PSO 6 – Microorganisms in medicine
PSO 7 – Nanoscale entities and its significance in medicine
PSO 8 – Tissue architecture engineering in medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and artificial intelligence in medicine
PSO 11 –Technology in personalizing medicine
PSO 12 – Protein structural complexity in medicine
PSO 13 – Projecting science and medicine to public
| – | PSO1 | PSO2 | PSO3 | PSO4 | PSO5 | PSO6 | PSO7 | PSO8 | PSO9 | PSO10 | PSO11 | PSO12 | PSO13 |
| C O | |||||||||||||
| CO 1 | 1 | – | – | — | – | – | – | – | – | – | – | – | 1 |
| CO 2 | 1 | – | – | — | – | – | – | – | – | – | – | – | 1 |
| CO 3 | 1 | – | – | – | – | – | – | – | – | – | – | – | 1 |
| CO 4 | 1 | – | – | – | – | – | – | – | – | – | – | – | 1 |
| CO 5 | 1 | – | – | – | – | – | – | – | – | – | – | – | 1 |
( 1 ) Graham Solomons, T.W., Fryhle, C.B. & Snyder, S.A. Organic Chemistry, John Wiley & Sons ( 2014 )
( 2 ) Sykes, P. A Guidebook to Mechanism in Organic Chemistry, Orient Longman, NewDelhi ( 1988 )
( 3 ) Finar, I.L. Organic Chemistry ( Vol. I & II ), E.L.B.S; Morrison, R.T. & Boyd, R.N. Organic Chemistry, Pearson, 2010;
( 4 ) Bahl, A. &Bahl, B.S. Advanced Organic Chemistry, S. Chand, 2010.
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