Preamble
The course gives an overview of basic understanding of cellular function and gene manipulation being harnessed to develop efficient therapy for the cure of different disease such as cancer and other disorders.
| Course Name | Cell Therapy |
| Course Code | 24MMD331 |
| Program | B. Sc. Honors (with Research) in Molecular Medicine |
| Semester | 5 |
| Credits | 3 |
| Campus | Kochi |
The course gives an overview of basic understanding of cellular function and gene manipulation being harnessed to develop efficient therapy for the cure of different disease such as cancer and other disorders.
What is cell therapy and its significance? When does a cell therapy is required? What type of cells are used for cell therapy and why? Disease requiring cell therapy.
Cell function enhancement by genetic engineering of these cells. Emerging approaches that are used for genetic modification. Examples of cell therapy in the context of cancer and other disorders.
Engineered T cells, history of CAR T development and CAR-T cell therapy in haematological malignancies, Different strategies adopted to culture cells for therapy, Link between cell therapy development in the laboratory and commercial therapy.
Advantages and limitations of cell therapy. Toxicities associated with cell therapy; Regulations applicable to cell therapies. Analytical methods for safe and effective quality control for the effectiveness of therapy. Preparation of patients for cell therapy. Continuous monitoring of patients following cell therapy.
Course Outcomes
CO1 To understand the significance of cell therapy in treating debilitating diseases
CO2 To learn about types of cells used in cell therapy
CO3 To learn how cells are modified genetically and the application of such cells in treating cancer and other disorders
CO4 To learn about CAR T cells, its development and application of CAR T therapy in hematological malignancies
CO5 To learn about the pros and cons of cell therapy, regulatory and ethical aspects, and preparation and monitoring of patients
Program Outcome
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
| c
C O |
PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 |
| CO 1 | 3 | 3 | 3 | 2 | 3 | 3 | 1 | – | – | – | – | 3 |
| CO 2 | 3 | 3 | 3 | 2 | 3 | 3 | 1 | – | – | – | – | 3 |
| CO 3 | 3 | 3 | 3 | 2 | 3 | 3 | 1 | – | – | – | – | 3 |
| CO 4 | 3 | 3 | 3 | 2 | 3 | 3 | 1 | – | – | – | – | 3 |
| CO 5 | 3 | 3 | 3 | 2 | 3 | 3 | 1 | 3 | – | – | – | 3 |
3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity
Program Specific Outcomes. (PSO)
PSO 1 – Chemical and physical basis of biology
PSO 2 – Computational science in biology and medicine
PSO 3 – Biochemical and physiological complexity in biology and medicine
PSO 4 – Molecular technology in biology and medicine
PSO 5 – Cell based approaches in diagnosis and therapy
PSO 6 – Microorganisms in medicine
PSO 7 – Nanoscale entities and its significance in medicine
PSO 8 – Tissue architecture engineering in medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and artificial intelligence in medicine
PSO 11 –Technology in personalizing medicine
PSO 12 – Protein structural complexity in medicine
PSO 13 – Projecting science and medicine to public
| –
C O |
PSO1 | PSO2 | PSO3 | PSO4 | PSO5 | PSO6 | PSO7 | PSO8 | PSO9 | PSO10 | PSO11 | PSO12 | PSO13 |
| CO 1 | – | 1 | 3 | 3 | 3 | – | – | – | – | – | 3 | – | 3 |
| CO 2 | – | 1 | 3 | 3 | 3 | – | – | – | – | – | 3 | – | 3 |
| CO 3 | – | 1 | 3 | 3 | 3 | – | – | – | – | – | 3 | – | 3 |
| CO 4 | – | 1 | 3 | 3 | 3 | – | 1 | – | – | – | 3 | – | 3 |
| CO 5 | – | 1 | 3 | 3 | 3 | 1 | – | – | – | – | 3 | – | 3 |
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Internal Assessment – 50% |
||
|
Periodical 1 |
Exam |
20% |
|
Periodical 2 |
Exam |
20% |
|
Continuous Assessment |
Assignment/Test/Quiz |
10% |
|
50% |
||
|
End Semester Examination- 50% |
||
|
Theory Exam |
50% |
|
|
50% |
||
|
Total |
100% |
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