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Course Detail

Course Name Cell biology
Course Code 24MMD102
Program B. Sc. Honors (with Research) in Molecular Medicine
Semester 1
Credits 3
Campus Kochi

Syllabus

Preamble

This course is to introduce the cell as a basic unit of life to the students of molecular medicine. It will elaborate the basic structure of the eukaryotic cells and the differences between the prokaryotic and eukaryotic cells. Further, the course will make the students understand the basic organization of eukaryotic cells, the endomembrane system, structure and functions of cell organelle, intracellular transport, the cytoskeleton, communication of cells with its surroundings and other cells and how cells reproduce through cell division. The course is devised in such a manner that the students will get a basic idea on the cellular bases of diseases.

Unit 1

The Cell: Introduction to cell theory, Comparison of a generalized pro- and eukaryotic cell

Methods in Cell Biology: Elementary idea of microscopy and cell fractionation.

Unit 2

Organization of cell: Extranuclear ( Elementary knowledge of structure and function of plasma membrane; Introduction to endomembrane system ( endoplasmic reticulum, Golgi complex, lysosome, peroxisome; Introduction to cytoskeleton; Structure and functions of mitochondria ) ; Nuclear ( Nuclear envelope, nucleolus and biogenesis of ribosome ).

Unit 3

Membrane transport: Principles of membrane transport, Channel proteins, carrier proteins; Passive and active transport.

Unit 4

Intracellular transport and protein sorting; Signal peptides and protein targeting; Entry and passage of proteins through endoplasmic reticulum; Processing and sorting of proteins in Golgi Apparatus; Endosomes and lysosomes; Nuclear pore complex and nuclear transport

Unit 5

Mitochondria and energy transfer: Electron transport and oxidative phosphorylation.

Unit 6

Cytoskeleton: Organisation and functions; Microtubular organelles.

Unit 7

Cell-cell communication: Cell junctions; Cell adhesion and extracellular matrix; General principles of cell signaling.

Unit 8

Cell reproduction: Basic features of cell cycle; Mitosis, mitotic spindle and chromosome movement; Process and phases of meiosis and its significance; Genetic regulation of cell cycle.

Objectives and Outcomes

Course Outcome

CO1 To understand cell as the basic unit of life and the differences between eukaryotic and prokaryotic cells

CO2 To learn the basic organization of cells, plasma membrane, cell organelles and the endomembrane system

CO3 To know the principles governing membrane transport, different types of transport systems, intracellular trafficking and protein sorting

CO4 To learn about mitochondria and energy transfer, cytoskeleton, communication between cells and cell to cell as well as cell to matrix junctions

CO5 To learn how cells reproduce through cell cycles, mitosis and meiosis, contribution of mitotic spindle in chromosome movement and genetic regulation of cell cycle

Program Outcome

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

c PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12
C O
CO 1 3 1 2 2 2 3 2 3
CO 2 3 1 2 2 2 3 2 3
CO 3 3 1 2 2 2 3 2 3
CO 4 3 1 2 2 2 3 2 3
CO 5 3 1 2 2 2 3 2 3

Program Specific Outcomes. ( PSO )

PSO 1 – Chemical and physical basis of biology

PSO 2 – Computational science in biology and medicine

PSO 3 – Biochemical and physiological complexity in biology and medicine

PSO 4 – Molecular technology in biology and medicine

PSO 5 – Cell based approaches in diagnosis and therapy

PSO 6 – Microorganisms in medicine

PSO 7 – Nanoscale entities and its significance in medicine

PSO 8 – Tissue architecture engineering in medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and artificial intelligence in medicine

PSO 11 –Technology in personalizing medicine

PSO 12 – Protein structural complexity in medicine

PSO 13 – Projecting science and medicine to public

PSO1 PSO2 PSO3 PSO4 PSO5 PSO6 PSO7 PSO8 PSO9 PSO10 PSO11 PSO12 PSO13
C O
CO 1 3 1 3 2 3 1 2 1 2 3
CO 2 3 1 3 2 3 1 2 1 2 3
CO 3 3 1 3 2 3 1 2 3 2 3
CO 4 3 1 3 2 3 1 2 1 2 3
CO 5 3 1 3 2 3 1 2 1 2 3

Evaluation Pattern

Internal Assessment – 50% 

Periodical 1 

Exam 

20% 

Periodical 2 

Exam 

20% 

Continuous Assessment 

Assignment/Test/Quiz

10% 

50%

End Semester Examination- 50% 

Theory Exam 

50% 

50%

Total

100%

Text Books / References

( 1 ) Karp: Cell and Molecular Biology ( 2008, John Wiley )

( 2 ) Lodish et al: Molecular Cell Biology ( 2008, Freeman )

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