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Course Detail

Course Name Biostatistics
Course Code 24MMD114
Program B. Sc. Honors (with Research) in Molecular Medicine
Semester 2
Credits 2
Campus Kochi

Syllabus

Preamble

Strategy to execute research is central to the successful completion and execution of a scientific endeavour. Based on the literature, several methodologies have been developed to tailor a particular strategy and the appropriate use of sample numbers for reliable results and meaningful outcome.

Unit 1

Introduction to Biostatistics-Need for Statistical Methods in Medicine, Public Health, Biology, Biotechnology & Nano Sciences – Their uses and Misuses, Types of Variables, Data collection Methods, Population and Sample. Linear Algebra – Set Theory – Sets and operations on sets.

Unit 2

Descriptive Data Analysis Methods – Statistical Tables, Diagrams & Graphs, Measures of Averages, Measures of Dispersion, Correlation Analysis Methods, Regression Analysis Methods. Theory of probability and Standard Distributions- Frequency and classical definition of probability, Axiomatric definition of probability, Addition and multiplication theorems, Conditional probability and independence, Random Variables.

Unit 3

Probability Distributions :- Definition of discrete and continuous random variables, Probability density functions and distribution functions, Standard univariate discrete distributions – Binomial, Poisson, Standard univariate continuous distributions – Normal, standard normal. Logic of Statistical Inference- Concept of parameter and statistic ‘, Estimators and its properties, point and Interval estimation of parameters, Confidence intervals, concept of standard error. Principles of statistical tests of significance, Methods of tests of Significance of Significance of Statistical Hypotheses- Concept of Statistical Hypotheses – Null and Alternative hypotheses, Type I and Type II errors, Significance level, Critical region and Power of a test , p- value and its interpretation; Large and Small Sample Test – Normal test, Student’s ‘t’ test, Chi-square tests, Analysis of variance.

Objectives and Outcomes

Program Specific Outcomes. (PSO)

PSO 1 – Chemical and physical basis of biology

PSO 2 – Computational science in biology and medicine

PSO 3 – Biochemical and physiological complexity in biology and medicine

PSO 4 -Molecular technology in biology and medicine

PSO 5 – Cell based approaches in diagnosis and therapy

PSO 6 – Microorganisms in medicine

PSO 7 -Nanoscale entities and its significance in medicine

PSO 8 – Tissue architecture engineering in medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and artificial intelligence in medicine

PSO 11 –Technology in personalizing medicine

PSO 12 – Protein structural complexity in medicine

PSO 13 – Projecting science and medicine to public

PSO 14 – Advanced knowledge in statistical techniques for medical research

PSO 15 – Skills in handling research data and presentation of results

PSO1

PSO2

PSO3

PSO4

PSO5

PSO6

PSO7

PSO8

PSO9

PSO10

PSO11

PSO14

PSO15

C O

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CO 2

CO 3

CO 4

CO 5

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