Syllabus
Unit I
Introduction: Laws of Physics and Chemistry, introduction to crystallography, Introduction to chromatography, electrophoresis Physico-Chemical Techniques to studyBiomolecules: hydration of macromolecules, diffusion of osmosis, sedimentation, ultracentrifuge, rotational dissuasion, light scattering, small angle X-ray scattering, Mass spectrometry.
Unit II
Spectroscopy: UV spectroscopy, circular dichroism, Fluorescence spectroscopy, IR, Raman and Electron spin spectroscopy, NMR spectroscopy.
Unit III
Molecular Modeling & Macromolecular Structure: building the structure of H2O2, , nucleic-acid structure, monomers, polymers, double helical structure of DNA, Polymorphism and nanostructure of DNA, structure of RNA, protein structure: amino acids, virus structure
Unit IV
Energy Pathways in Biology: free energy, couple reactions, group transfer potential, Pyridinenucleotides, photosynthesis, energy conversion pathways, membrane transport. Biomechanics: strained muscles, mechanical properties of muscles, cardiovascular-system.
Unit V
Neurobiophysics: nervous system, physics of membrane potentials, sensory mechanisms. Origin and evolution of life: prebiotic earth, theories of origin and evolution of life, laboratory experiments on formation of small molecules.
Objectives and Outcomes
OBJECTIVE: To enable students to study the selected biological phenomena using physical principles.
Course outcomes:
- Ability to explain the basics laws in physics and chemistry, various techniques to study biomolecules.
- Be able to apply various spectroscopic methods to study biomolecules.
- Ability to explain fundamentals of molecular modelling and macromolecular structure.
- Be able to apply the neuro science as application in biophysics.
CO – PO Mapping
|
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PSO1 |
PSO2 |
PSO3 |
PSO4 |
CO1 |
3 |
1 |
3 |
3 |
3 |
1 |
1 |
|
|
|
3 |
2 |
3 |
|
CO2 |
3 |
1 |
3 |
3 |
3 |
1 |
1 |
|
|
|
3 |
2 |
3 |
|
CO3 |
3 |
1 |
3 |
3 |
3 |
1 |
1 |
|
|
|
3 |
2 |
3 |
|
CO4 |
3 |
1 |
3 |
3 |
3 |
1 |
1 |
|
|
|
3 |
2 |
3 |
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Text Books / References
Neurobiophysics: nervous system, physics of membrane potentials, sensory mechanisms. Origin and evolution of life: prebiotic earth, theories of origin and evolution of life, laboratory experiments on formation of small molecules.