Unit 1

Artificial Heart & Circulatory Assist Devices Engineering Design of artificial Heart & Circulatory Assist Devices; Detailed Design to execute the plant; Heart Assist Technology; Blood Pumps; Prosthetic Heart Valves.

Unit 2

Artificial Blood & Cochlear Implant Blood components & characteristics; Oxygen carrying plasma expanders; Blood substitutes; Crystalloid & colloidal solutions as volume expanders; Artificial oxygen carriers; Fluorocarbons; Haemoglobin based artificial blood. Cochlear Implant: Introduction; candidates for implant; the auditory system; the auditory periphery; theory of operation; evaluation of cochlear prosthesis; benefits & risks of implantation; the cost of implantation; the future of cochlear prosthesis.

Unit 3

Artificial Skin Structure & functions of skin; Characteristics & clinical use of skin substitutes; Two conceptual stages in the treatment of massive skin loss; Skin substitutes: characteristics & uses, types of skin substitutes.

Unit 4

Artificial Pancreas & Artificial Lungs Parenteral Structure & function of Pancreas; Endocrine pancreas & insulin secretion; Diabetes; Insulin therapy; Insulin administration systems; Insulin production systems. Artificial Lungs: Gas exchange systems; Cardiopulmonary Bypass; Oxygen & CO2 transport; Coupling of oxygen & CO2 exchange; Shear-Induced Transport Augmentation and Devices for Improved Gas Transport.

Course objectives:

To have an overview of artificial organs and transplants
To describe the principles of implant design with a case study
To study about various organs replacement concept
To study about physical parameters for concept design of artificial organs

Course Outcomes:

After completing this course, students should be able to
CO1: Design artificial hearts and circulatory assist devices based on engineering principles.
CO2: Demonstrate knowledge of the various components of artificial blood and their clinical applications.
CO3: Understand the structure and functions of artificial skin, along with its clinical uses and types.
CO4: Evaluate the design and functionality of artificial pancreas systems and artificial lungs for gas exchange.

CO-PO Mapping

1. Bronzino J. D, The Biomedical Engineering Handbook. Germany: CRC Press, 2000.
2. Artificial Organs, Netherlands: Springer London. Optional Materials: Reference Books, 2009.
3. Miller G. E., Artificial Organs. United States: Morgan & Claypool Publishers, 2006.
4. Schoen, F. J., Ratner, B. D., Hoffman, A. S., Lemons, J. E,. Biomaterials Science: An Introduction to Materials in Medicine. Netherlands: Elsevier Science, 2004.