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Dr. Sowmya Srinivasan

Research Scientist, Department of Periodontics, School of Dentistry, Kochi

Qualification: BDS, M.Tech., Ph.D
sowmyasrinivasan@aims.amrita.edu

Bio Publications Education and Professional Experience Reviewer Research Interest & Skills Professional Memberships Awards and Honors Projects Conference and Seminar Presentations
Bio

Dr. Sowmya Srinivasan currently serves as Research Scientist & ICMR Research Associate Fellow in the Department of Periodontics, Amrita School of Dentistry, Health Sciences Campus, Kochi.

Dr. Sowmya Srinivasan obtained her BDS degree from SRM Dental College, SRM University, Chennai, Tamil Nadu with Grade A in 2007. She worked as a dental surgeon at RR Dental Hospital, Chennai till 2008. She then completed M Tech in Nanomedical Sciences with distinction in 2010 from Amrita Centre for Nanosciences & Molecular Medicine, Amrita Vishwa Vidyapeetham University, Kochi, Kerala. She obtained PhD in Dental Tissue Engineering in 2016 from Amrita Vishwa Vidyapeetham University, Kochi, Kerala.

She has been working as a Research Scientist at Amrita School of Dentistry, Kochi since 2017. Her job is to help & provide research guidance to dental faculties and post-graduate students for planning and executing research studies. Also provide assistance for manuscript writing and research proposal preparation for government & non-government funding agencies.

Her research interests include dental tissue engineering, 3D printing, stem cell isolation and culture from dental and non-dental sources, periodontal and pulp regeneration, in vivo animal model development and surgery. Her skills include isolation, culture and differentiation of periodontal, pulp and dental follicle stem cells into specific lineages; fabrication of nanomaterials, composites, bioceramics, scaffolds, hydrogels, 3D printed biomaterials for dental, bone and regenerative medicine applications; biochemical & cell-based assays, immunocytochemistry, isolation of growth factors from platelet rich plasma (PRP), microbial culture and evaluation of antibacterial activity. She has hands-on experience in immunofluorescent analysis, flow cytometry, fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), UV-VIS spectrometry, freeze-dryer (lyophilizer), fluorescent microscopy, plate reader.

Her PhD dissertation was focused on the “development of biocompatible trilayered nanocomposite hydrogel scaffold for periodontal regeneration.”

She serves as a reviewer for several international journals. She has 18 publications to her credit with a h-index of 17 and total citations above 1500.

Publications

Journal Article

Year : 2017

Pro-angiogenic Molecules for Therapeutic Angiogenesis.

Cite this Research Publication : V. Selvaprithviraj, Sankar, D., Sivashanmugam, A., Sowmya Srinivasan, and Dr. Jayakumar Rangasamy, “Pro-angiogenic Molecules for Therapeutic Angiogenesis.”, Curr Med Chem, vol. 24, no. 31, pp. 3413-3432, 2017.

Publisher : Curr Med Chem, Bentham Science Publishers B.V.,

Year : 2016

Bilayered Construct for Simultaneous Regeneration of Alveolar Bone and Periodontal Ligament

Cite this Research Publication : Nivedhitha Sundaram M., Sowmya Srinivasan, Deepthi, S., Bumgardener, J. D., and Dr. Jayakumar Rangasamy, “Bilayered Construct for Simultaneous Regeneration of Alveolar Bone and Periodontal Ligament”, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2016.

Publisher : Journal of Biomedical Materials Research - Part B Applied Biomaterials, John Wiley and Sons Inc.

Year : 2015

Periodontal Specific Differentiation of Dental Follicle Stem Cells into Osteoblast, Fibroblast and Cementoblast

Cite this Research Publication : Dr. Jayakumar Rangasamy, Sowmya Srinivasan, P, C. K., H, A., P, J., and Shantikumar V Nair, “Periodontal Specific Differentiation of Dental Follicle Stem Cells into Osteoblast, Fibroblast and Cementoblast”, Tissue Engineering-C: Methods, vol. 21, no. 10, pp. 1044-1058, 2015.

Publisher : Tissue Engineering-C: Methods

Year : 2014

Tetracycline Nanoparticles Loaded Calcium Sulfate Composite Beads for Periodontal Management

Cite this Research Publication : S. N. Reddy, Sowmya Srinivasan, Bumgardner, J. D., Chennazhi, K. P., Dr. Raja Biswas, and Dr. Jayakumar Rangasamy, “Tetracycline Nanoparticles Loaded Calcium Sulfate Composite Beads for Periodontal Management”, Biochimica et Biophysica Acta - General Subjects, vol. 1840, pp. 2080-2090, 2014.

Publisher : Biochimica et Biophysica Acta - General Subjects

Year : 2014

Chitin and Chitosan in Selected BiomedicalApplications

Cite this Research Publication : A. Anitha, Sowmya Srinivasan, Kumar, P. T. S., Deepthi, S., Chennazhi, K. P., Ehrlich, H., Tsurkan, M., and Dr. Jayakumar Rangasamy, “Chitin and Chitosan in Selected Biomedical Applications”, Progress in Polymer Science, vol. 39, pp. 1644-1667, 2014.

Publisher : Progress in Polymer Science, Elsevier Ltd,

Year : 2013

Role of Nanostructured Biopolymers and Bioceramics in Enamel, Dentin and Periodontal Tissue Regeneration

Cite this Research Publication : Sowmya Srinivasan, Bumgardener, J. D., Chennazhi, K. P., Nair, S. V., and Dr. Jayakumar Rangasamy, “Role of Nanostructured Biopolymers and Bioceramics in Enamel, Dentin and Periodontal Tissue Regeneration”, Progress in Polymer Science, vol. 38, pp. 1748-1772, 2013.

Publisher : Progress in Polymer Science

Year : 2013

Effect of incorporation of nanoscale bioactive glass and hydroxyapatite in PCL/chitosan nanofibers for bone and periodontal tissue engineering

Cite this Research Publication : K. T. Shalumon, Sowmya Srinivasan, Sathish, D., Chennazhi, K. P., Nair, S. V., and Dr. Jayakumar Rangasamy, “Effect of incorporation of nanoscale bioactive glass and hydroxyapatite in PCL/chitosan nanofibers for bone and periodontal tissue engineering”, Journal of Biomedical Nanotechnology, vol. 9, pp. 430-440, 2013.

Publisher : Journal of Biomedical Nanotechnology

Year : 2013

Antibacterial and bioactive α- And β-chitin hydrogel/ nanobioactive glass ceramic/nano silver composite scaffolds for periodontal regeneration

Cite this Research Publication : Sowmya Srinivasan, Kumar, P. T. Sudheesh, Nair, S. V., Chennazhi, K. P., and Dr. Jayakumar Rangasamy, “Antibacterial and bioactive α- And β-chitin hydrogel/ nanobioactive glass ceramic/nano silver composite scaffolds for periodontal regeneration”, Journal of Biomedical Nanotechnology, vol. 9, pp. 1803-1816, 2013.

Publisher : Journal of Biomedical Nanotechnology

Year : 2012

A new leakage power reduction technique for CMOS VLSI circuits

Cite this Research Publication : M. Ga Priya, Baskaran, Kb, Krishnaveni, Dc, and Srinivasan, Sd, “A new leakage power reduction technique for CMOS VLSI circuits”, Journal of Artificial Intelligence, vol. 5, pp. 227-232, 2012.

Publisher : Journal of Artificial Intelligence

Year : 2012

Multiscale fibrous scaffolds in regenerative medicine

Cite this Research Publication : Sowmya Srinivasan, Chennazhi, K. P., Levorson, E. J., Mikos, A. G., and Nair, S. V., “Multiscale fibrous scaffolds in regenerative medicine”, Advances in Polymer Science, vol. 246, pp. 1-20, 2012.

Publisher : Advances in Polymer Science

Year : 2012

Electrospinning of biocompatible polymers and their potentials in biomedical applications

Cite this Research Publication : P. Supaphol, Suwantong, O., Sangsanoh, P., Sowmya Srinivasan, Dr. Jayakumar Rangasamy, and Nair, S. V., “Electrospinning of biocompatible polymers and their potentials in biomedical applications”, Advances in Polymer Science, vol. 246, pp. 213-240, 2012.

Publisher : Advances in Polymer Science

Year : 2012

Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration

Cite this Research Publication : Sowmya Srinivasan, Jayasree, R., Chennazhi, K. P., Shantikumar V. Nair, and Dr. Jayakumar Rangasamy, “Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration”, Carbohydrate Polymers, vol. 87, pp. 274-283, 2012.

Publisher : Carbohydrate Polymers

Year : 2011

Chitin Scaffolds in Tissue Engineering

Cite this Research Publication : Dr. Jayakumar Rangasamy, Chennazhi, K. P., Sowmya Srinivasan, Shantikumar V Nair, Furuike, T., and Tamura, H., “Chitin Scaffolds in Tissue Engineering”, International Journal of Molecular Sciences, vol. 12, pp. 1876-1887, 2011.

Publisher : International Journal of Molecular Sciences

Year : 2011

β-Chitin hydrogel/nano hydroxyapatite composite scaffolds for tissue engineering applications

Cite this Research Publication : P. T. Sudheesh Kumar, Sowmya Srinivasan, Lakshmanan, V. - K., Tamura, H., Nair, S. V., and Dr. Jayakumar Rangasamy, “β-Chitin hydrogel/nano hydroxyapatite composite scaffolds for tissue engineering applications”, Carbohydrate Polymers, vol. 85, pp. 584-591, 2011.

Publisher : Carbohydrate Polymers

Year : 2011

Synthesis, Characterization and Cytocompatibility Studies of α-chitin Hydrogel/nano Hydroxyapatite Composite Scaffolds

Cite this Research Publication : P. T. S. Kumar, Sowmya Srinivasan, Lakshmanan, V. - K., Tamura, H., Nair, S. V., and Dr. Jayakumar Rangasamy, “Synthesis, Characterization and Cytocompatibility Studies of α-chitin Hydrogel/nano Hydroxyapatite Composite Scaffolds”, International Journal of Biological Macromolecules, vol. 49, pp. 20-31, 2011.

Publisher : International Journal of Biological Macromolecules

Year : 2011

Fabrication of chitin-chitosan/nano ZrO2 composite scaffolds for tissue engineering applications

Cite this Research Publication : Dr. Jayakumar Rangasamy, Ramachandran, R., Kumar, P. T. Sudheesh, Divyarani, V. V., Sowmya Srinivasan, Chennazhi, K. P., Tamura, H., and Nair, S. V., “Fabrication of chitin-chitosan/nano ZrO2 composite scaffolds for tissue engineering applications”, International Journal of Biological Macromolecules, vol. 49, pp. 274-280, 2011.

Publisher : International Journal of Biological Macromolecules

Year : 2011

Chitin Scaffolds in Tissue Engineering

Cite this Research Publication : Dr. Jayakumar Rangasamy, Chennazhi, K. P., Sowmya Srinivasan, Shantikumar V Nair, Furuike, T., and Tamura, H., “Chitin Scaffolds in Tissue Engineering”, International Journal of Molecular Sciences, vol. 12, pp. 1876-1887, 2011.

Publisher : International Journal of Molecular Sciences

Year : 2011

Biocompatible β-chitin Hydrogel/nanobioactive Glass Ceramic Nanocomposite Scaffolds for Periodontal Bone Regeneration

Cite this Research Publication : Sowmya Srinivasan, Kumar, P. T. S., Chennazhi, K. P., Nair, S. V., Tamura, H., and Dr. Jayakumar Rangasamy, “Biocompatible β-chitin Hydrogel/nanobioactive Glass Ceramic Nanocomposite Scaffolds for Periodontal Bone Regeneration”, Trends in Biomaterials and Artificial Organs, vol. 25, pp. 1-11, 2011.

Publisher : Trends in Biomaterials and Artificial Organs

Book Chapter

Year : 2019

Nanohybrid scaffold structures for smart drug delivery applications

Cite this Research Publication : Sowmya Srinivasan, “Nanohybrid scaffold structures for smart drug delivery applications”, in Biomimetic Nanoengineered Materials for Advanced Drug Delivery, A. Rajan Unnithan, Sasikala, A. Ramachandr, Park, C. Hee, and Kim, C. Sang, Eds. Elsevier, 2019, pp. 53 - 59.

Publisher : Biomimetic Nanoengineered Materials for Advanced Drug Delivery

Education and Professional Experience
  • 2017 – Present: Research Scientist, Amrita School of Dentistry, Kochi
  • 2010 – 2016: Ph. D. in Dental Tissue Engineering from Amrita Vishwa Vidyapeetham University, Kochi (CGPA of 9.33 out of 10)
  • 2008 – 2010: M. Tech. in Nanomedical Sciences, Amrita Centre for Nanosciences & Molecular Medicine, Kochi (CGPA of 8.5 out of 10)
  • 2007 – 2008: Dental Surgeon, RR Dental Hospital, Chennai
  • 2002 – 2007: BDS, SRM Dental College, Chennai
Reviewer
  • International Journal of Biological Macromolecules
  • Carbohydrate Polymers
  • International Journal of Molecular Sciences
  • International Journal of Oral Science
  • Materials
  • Applied Sciences
  • Dentistry Journal
  • Pharmaceutics
  • ACS Applied Materials & Interfaces
  • Advanced Healthcare Materials
  • Journal of Biomaterials Science
Research Interest & Skills
  • 3D printed biomaterials for dental tissue engineering
  • Cell culture – stem cells, primary cells and cell lines
  • Isolation, culture and characterization of stem cells from human and animal tissues of dental and non-dental sources
  • Stem cell differentiation into specific lineages – osteogenic, fibrogenic, cementogenic lineages
  • Assays –ELISA, PCR, Protein quantification by immunocytochemistry and flow cytometry, biomineralization, cell-based assays, In vitro angiogenesis
  • Growth factor/recombinant proteins-related studies, isolation of growth factors from platelet rich plasma (PRP)
  • Synthesis and characterization of bioceramics like hydroxyapatite, bioactive glass, calcium sulfate, whitlockite
  • Synthesis and characterization of nanomaterials & nanomaterial based composite scaffolds
  • Development of biodegradable, polymeric and ceramic based composites, scaffolds and hydrogels for diverse tissue engineering and regenerative applications
  • Development of growth factor/recombinant proteins incorporated constructs/ scaffolds
  • Hands-on experience in Immunofluorescent Analysis, Fourier Transform Infrared Spectroscopy (FT-IR), Dynamic Light Scattering (DLS), UV-VIS Spectrometer, Flow cytometry, Freeze-Dryer (lyophilizer), Fluorescent Microscope, Plate Reader
  • Microbial culture and evaluation of antibacterial activity
  • In vivo animal model development and surgery – Rabbit and rat models
  • Immunohistochemistry and Micro-CT for in vivo analysis
Professional Memberships
  1. Life Membership in Society for Biomaterials & Artificial Organs (SBAOI, India)
  2. Member of Indian Dental Association and Tamil Nadu Dental Council (Regd. No. 10623)
Awards and Honors
  1. Research Associate Fellowship awarded by Indian Council of Medical Research (ICMR) in March 2020.
  2. Best Student Researcher Award (2014-2015) received at National Conference on Application of the Derivatives of Chitin and Chitosan, Dindigul, Tamil Nadu, India.
  3. Senior Research Fellowship for 4 years awarded by Council of Scientific and Industrial Research, Government of India in 2012.
  4. Junior Research Fellowship for 2 years from Nanomission, Department of Science & Technology (DST), Government of India under the “Thematic Unit of Excellence” grant in 2010.
  5. Best poster award received at 1st Indian Chitin & Chitosan Society Symposium (ICCS-2010), Coimbatore, Tamil Nadu.
Projects
  1. 3D-printed Mesh with Injectable Nanocomposite Gel for Bone Augmentation following Tooth Extraction – ICMR Research Associate Award (Initiated in April 2020, Status: Ongoing)
  2. Pilot study on the histological analysis of dental pulp tissue harvested from irreversible pulpitis cases- In collaboration with the Department of Oral Pathology and Department of Conservative Dentistry and Endodontics (Initiated in 2019, Status: Ongoing)
  3. Antibacterial activity of different tea preparations against periodontal pathogens – In collaboration with Department of Periodontics and Amrita Center for Nanosciences & Molecular Medicine (2018-2020, Status: Ready for publication)
  4. Undergraduate research project on biomimetic materials and therapeutic strategies applied in the treatment of horizontal bone loss – A Review (Initiated in 2019, Status: Ongoing)
Conference and Seminar Presentations
  1. Invited webinar on “Venturing into Dental Research” organized by Chettinad Dental College & Research Institute, Chennai on May 28, 2020.
  2. Invited talk on “Venturing into Ph. D.” at Perio Sameeksha, Intensive Academic Review Programme, Amrita School of Dentistry, February 22 – 214 2018.
  3. Presented poster on “Layered Nanocomposite Scaffold for Regeneration of Periodontium Complex” at Indo-Australian Conference on Biomaterials, Tissue Engineering, Drug Delivery system & Regenerative Medicine BiTERM 2015 Anna University, Chennai, February 6 – 8, 2015.
  4. Oral presentation on “Chitin/PLGA/nBGC Hydrogel Scaffold for Periodontal Regeneration” at Indian Chitin and Chitosan Society Symposium, Gandhigram Rural University, August 22 – 23, 2014.
  5. Presented poster titled “Fabrication of Biocompatible and Biodegradable Nanocomposite Scaffolds” at Amrita Bioquest, International Conference on Biotechnology for Innovative Applications, Kollam, Kerala, August 10 – 14, 2013.
  6. Presented poster titled “Chitin/PLGA/nBGC Nanocomposite Scaffolds for Alveolar Bone and Periodontal Ligament Regeneration” at 5th Bangalore Nano, Bangalore, December 6 – 7, 2012.
  7. Presented poster titled “Chitin/PLGA/nBGC Hydrogel Composite Scaffolds: A Boon For Periodontal Regeneration” at NANOBIO-2012, February 21 – 23, 2012, Amrita Centre for Nanosciences, Amrita Institute for Medical Sciences and Research Centre, Cochin, Kerala, India.
  8. Oral presentation on “Chitin/PLGA/nBGC Composite Scaffolds for Periodontal Tissue Regeneration” at International Conference on Biomaterials, Implants and Tissue Engineering, BIDTE 2012, Rajalakshmi Engineering College, Chennai, India, January 6 – 8, 2012.
  9. Oral presentation on “Antibacterial α and β-Chitin/Nano Bioglass/Nanosilver Composite Scaffolds for Periodontal Bone Regeneration” at 2nd Indian Chitin & Chitosan Society Symposium (II ICCS 2011), Hyderabad, India.
  10. Presented poster titled “Biocompatible Alginate/Nano Bioactive Glass Ceramic Composite Scaffolds for Periodontal Tissue Regeneration” at The Third International Conference on Frontiers in Nanoscience and Technology (Cochin Nano-2011), IMA House, Cochin, Kerala, India.
  11. Presented poster titled “Antibacterial β-Chitin/Nano Bioglass/Nanosilver Composite Scaffolds for Periodontal Bone Regeneration” at 1st Indian Chitin & Chitosan Society Symposium (I ICCS 2010), Coimbatore, India.
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