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Dr. Akhil Sivan

Assistant Professor(Sr. Gd.), Chemistry, School of Physical Science, Amritapuri

Qualification: Ph.D., M. Sc., B. Sc.
akhilsivan@am.amrita.edu
Google Scholar Profile
Research Interest: Heterocyclic Organic Synthesis, Isolation, Purification and Characterization of Natural Products, Solid Supported Organic Synthesis, Organic-base Catalyzed Synthesis, Lanthanide and Transition Metal Catalyzed Radical Chemistry, Heterogeneous Catalysis, Photophysical studies of organic compounds, Multi-component reactions, Computational Chemistry and Polymer Chemistry.

Bio Publications Current Research Topics Master’s Theses Guided Experience Research Experiences Professional Experiences Research Activities Achievements & Awards Research Collaborators Courses Handled Administrative Roles
Bio

Dr. Akhil Sivan currently serves as an Assistant Professor (Sr. Gr.) in the Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri Campus. He completed his Master’s degree in Advanced Organic Chemistry from the University of Kerala in 2008. He completed his Ph. D. from Amrita Vishwa Vidyapeetham in 2018 in the broad subject area of “Synthetic Organic Chemistry,” where special emphasis has been given to the synthesis of heterocycles and spirocycles and the construction of carbon-carbon and carbon-heteroatom bonds using Cerium(IV) Ammonium Nitrate (CAN) as a single electron transfer oxidant. His research interests include heterocyclic synthesis, solid-supported and heterogeneous catalyst-mediated organic synthesis, lanthanide and transition metal-catalysed radical chemistry, and organic base-catalysed synthesis.

Educational Qualifications

  • Ph.D. in Organic Chemistry from Amrita Vishwa Vidyapeetham, India in 2018.
  • M. Sc. in Chemistry from University of Kerala, India in 2008 (First Class with Distinction).
  • B. Sc. in Industrial Chemistry from University of Kerala, India in 2005 (First Class with Distinction and University 3rd Rank).
Publications

Journal Article

Year : 2024

Single Step Upgradation of Isatin to Bioactive Fused Heterocycles via Ring Expansion Reactions

Cite this Research Publication : Raksha C., Ajil R. Nair, Anjana Sreekumar, Jayakrishnan Aerathupalathu Janardhanan, Akhil Sivan, Single Step Upgradation of Isatin to Bioactive Fused Heterocycles via Ring Expansion Reactions, European Journal of Organic Chemistry, 27, e202301000, 2024, https://doi.org/10.1002/ejoc.202301000

Year : 2024

D-A-D/A chalcones with tunable optical characteristics: Synthesis, photophysical, electrochemical and theoretical investigations

Cite this Research Publication : Ajil R. Nair, Raksha C., Heera R., Gayathri Mohan M., P. Manoj, Akhil Sivan, D-A-D/A Chalcones with Tunable Optical Characteristics: Synthesis, Photophysical, Electrochemical and Theoretical Investigations, Journal of Photochemistry & Photobiology, A: Chemistry, 451, 115511, 2024, https://doi.org/10.1016/j.jphotochem.2024.115511

Year : 2023

An Insight into the Recent Synthetic Approaches of Benzimidazole Motifs Based on Divergent Substrate Scope

Cite this Research Publication : Kavya G., Ajil R. Nair, Akhil Sivan, "An Insight into the Recent Synthetic Approaches of Benzimidazole Motifs Based on Divergent Substrate Scope" Mini-Reviews in Organic Chemistry, Vol. 20, 333 – 357, 2023, http://dx.doi.org/10.2174/1570193X19666220420134233

Year : 2022

An Easy Access to 2,3-Dihydrofuran Derivatives by Oxidative Cyclisation Reactions

Cite this Research Publication : P. Bamisha, Anjana Sreekumar, Anjana Gopinath, V. Aswathy, M. Ujwal Dev, Sona Santhosh, Akhil Sivan, “An Easy Access to 2,3-Dihydrofuran Derivatives by Oxidative Cyclisation Reactions”, Materials Today Proceedings, Vol. 59, Part 1, 1138-1143, 2022, https://doi.org/10.1016/j.matpr.2022.03.180

Year : 2022

Synthesis and in-depth investigation of the photophysical and electrochemical properties of novel pyrazole cored D-A-D molecules

Cite this Research Publication : Ajil R. Nair, Sunil Kumar Y. C., Akhil Sivan, "Synthesis and In-depth Investigation of the Photophysical and Electrochemical Properties of Novel Pyrazole Cored D-A-D Molecules", Optical Materials, Vol. 134, Part A, 113117, 2022, https://doi.org/10.1016/j.optmat.2022.113117

Year : 2022

An insight into the recent synthetic approaches of benzimidazole motifs based on divergent substrate scope

Cite this Research Publication : G Kavya, Nair R. Ajil and Sivan Akhil*, An Insight into the Recent Synthetic Approaches of Benzimidazole Motifs Based on Divergent Substrate Scope, Mini-Reviews in Organic Chemistry 2022; 19() . https://dx.doi.org/10.2174/1570193X19666220420134233

Publisher : Bentham Science

Year : 2022

Approaches to obtaining fluorenes: An alternate perspective

Cite this Research Publication : S. Das, Ajil R. Nair, Anjana Sreekumar and Akhil Sivan, "Approaches to obtaining fluorenes: An alternate perspective", ChemistrySelect (IF: 2.307, Q2), Wiley-Blackwell Publishing Ltd, 2022

Publisher : Wiley-Blackwell Publishing Ltd

Year : 2020

Organic base catalyzed synthesis of benzimidazole

Cite this Research Publication : Sarah John, G. Kavya, M. M. Aparna, R. Anuja Krishnan, R. Parvathy, T. S. Sreenath and Akhil Sivan, "Organic base catalyzed synthesis of benzimidazole", IOP Conference Series: Materials Science and Engineering, IOP Publishing, 2020

Publisher : IOP Publishing

Year : 2020

Organic base catalysed synthesis of benzimidazole

Cite this Research Publication : S. John, Kavya, G., Aparna, M. M., R Krishnan, A., Parvathy, R., Sreenath, T. S., and Akhil Sivan, “Organic base catalysed synthesis of benzimidazole”, IOP Conference Series: Materials Science and Engineering, vol. 872, p. 012142, 2020.

Publisher : IOP Conference Series: Materials Science and Engineering, IOP Publishing, Volume 872, p.012142 (2020)

Year : 2019

Synthesis of silver nanoparticles from a bioactive precursor

Cite this Research Publication : M. Leema, Sreekumar, G., Akhil Sivan, and Dr. Zeena S. Pillai, “Synthesis of silver nanoparticles from a bioactive precursor”, Materials Today: Proceedings, vol. 18, pp. 4724-4728, 2019.

Publisher : Materials Today: Proceedings, vol. 18, pp. 4724-4728, 2019.

Year : 2014

Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate

Cite this Research Publication : Akhil Sivan, Ani Deepthi, “Facile Synthesis of 1, 2, 3-Tricarbonyls from 1, 3-Dicarbonyls Mediated by Cerium(IV) Ammonium Nitrate”, Tetrahedron Letters, Vol. 55, 1890-1893, 2014, https://doi.org/10.1016/j.tetlet.2014.01.145

Year : 2011

Oxidative addition of 1,3-dicarbonyl compounds to terminal acetylenes mediated by cerium(IV) ammonium nitrate

Cite this Research Publication : Akhil Sivan, A. Deepthi, and V. Nandialath, “Oxidative addition of 1,3-dicarbonyl compounds to terminal acetylenes mediated by cerium(IV) ammonium nitrate”, Synthesis, vol. 15, pp. 2466-2470, 2011.

Publisher : Synthesis

Conference Proceedings

Year : 2014

Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate

Cite this Research Publication :
Akhil Sivan and A. Deepthi, “Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate”, Tetrahedron Letters, vol. 55, pp. 1890-1893, 2014

Publisher : Tetrahedron Letters

Year : 2014

An Efficient Synthesis of Spiro Dihydrofuran Fluorenes Using CAN Supported on Silica

Cite this Research Publication : Akhil Sivan, A. Deepthi, and K. S. Nair, “An Efficient Synthesis of Spiro Dihydrofuran Fluorenes Using CAN Supported on Silica”, National Seminar on Frontiers of Polymers and Advanced Materials. Dept. of Chemistry, University of Kerala, Trivandrum, Kerala, 2014.

Publisher : National Seminar on Frontiers of Polymers and Advanced Materials

Year : 2014

A Direct Synthesis of Vicinal Triketones from β-Diketones: 1,3 to 1,2,3

Cite this Research Publication : Akhil Sivan and A. Deepthi, “A Direct Synthesis of Vicinal Triketones from β-Diketones: 1,3 to 1,2,3”, 16th CRSI National Symposium in Chemistry. IIT Bombay, Powai, Mumbai, 2014.

Publisher : 16th CRSI National Symposium in Chemistry

Year : 2014

1,3-Diones to 1,2,3-Triones and 1,3,5-Triones to 1,2,3,4,5-Pentones

Cite this Research Publication : R. Anchu, Akhil Sivan, and A. Deepthi, “1,3-Diones to 1,2,3-Triones and 1,3,5-Triones to 1,2,3,4,5-Pentones”, National Symposium on Transcending Frontiers in Organic Chemistry. NIIST, Trivandrum, Kerala, 2014.

Publisher : National Symposium on Transcending Frontiers in Organic Chemistry

Year : 2012

Reactivity of Ethyl-2,3-butadienoate in Cerium (IV) ammonium nitrate (CAN) mediated intermolecular C-C bond formation

Cite this Research Publication : Akhil Sivan and A. Deepthi, “Reactivity of Ethyl-2,3-butadienoate in Cerium (IV) ammonium nitrate (CAN) mediated intermolecular C-C bond formation”, 14th CRSI National Symposium in Chemistry. NIIST, Trivandrum, Kerala, 2012.

Publisher : 14th CRSI National Symposium in Chemistry

Year : 2011

Synthesis of Multisubstituted Furans by Oxidative Addition

Cite this Research Publication : Akhil Sivan, Ani Deepthi, “Synthesis of Multisubstituted Furans by Oxidative Addition”, Recent Trends in Organic Synthesis, School of Chemistry, Bharathidasan University, Trichy, Tamil Nadu, 2011.

Year : 2011

Synthesis of tetrasubstituted furans by oxidative addition

Cite this Research Publication : Akhil Sivan and A. Deepthi, “Synthesis of tetrasubstituted furans by oxidative addition”, Recent Trends in Organic Synthesis. School of Chemistry, Bharathidasan University, Trichy, Tamil Nadu, 2011.

Publisher : Bharathidasan University

Year : 2011

Synthesis of Fused Furans by Oxidative Addition

Cite this Research Publication :
Akhil Sivan, A. Deepthi, and Vidya, N., “Synthesis of Fused Furans by Oxidative Addition”, National Seminar on Current Trends in Chemistry, Dept. of Applied Chemistry. Cochin University of Science and Technology, Kerala, 2011.

Publisher : Cochin University of Science and Technology

Book Chapter

Year : 2024

Silver Nanoparticles in Nanomedicine and Pharmaceutical Applications

Cite this Research Publication : Ajil R. Nair, Anjana Sreekumar, Aparna Asok, Akhila Raman, Akhil Sivan, Saritha Appukuttan, “Silver Nanoparticles in Nanomedicine and Pharmaceutical Applications”, 2024. (Accepted, Elsevier Publishing).

Year : 2024

MXene-Reinforced Polymer Composite Membranes for Water Desalination and Wastewater Treatment

Cite this Research Publication : Anjana Sreekumar, Ajil R. Nair, Akhila Raman, Kalim Deshmukh, Akhil Sivan, Mayank Pandey, Saritha Appukuttan, "MXene Reinforced Polymer Composite Membranes for Water Desalination and Wastewater Treatment", MXene Reinforced Polymer Composites: Fabrication, Characterization and Applications, Wiley, 459-500, 2024, https://doi.org/10.1002/9781119901280.ch14

Year : 2022

Exploring the Versatility of Benzimidazole Scaffolds as Medicinal Agents: A Brief Update

Cite this Research Publication : Gopakumar Kavya, Akhil Sivan, “Exploring the Versatility of Benzimidazole Scaffolds as Medicinal Agents: A Brief Update”, IntechOpen, 2022, https://www.intechopen.com/chapters/80130

Current Research Topics
  • Exploring the potential of heterocyclic/polyaromatic-cored organic compounds as suitable candidates in optical, sensing and biological applications
  • Design and synthesis of novel heterocyclic-rich organic frameworks for variable optical applications
  • Achieving bioactive molecules through multicomponent reactions and their computational studies

PhD Scholars’ Details

Student Details Research Topic
Anjana Sreekumar Exploring the potential of polyaromatic-cored organic compounds as suitable candidates in optical, sensing and biological application
Ajil R. Nair Design and synthesis of novel heterocyclic-rich small organic molecules for optical applications
Raksha C. Achieving bioactive molecules through multicomponent reactions and their computational studies
Master’s Theses Guided
No. Name of the Student Title of the Master’s Thesis Year of completion
1 Sarah John Organic Base Catalyzed Synthesis of Benzimidazoles 2019
2 Jency Babu Exploring the reactivity of DBU towards the synthesis of benzo fused heterocycles 2020
3 Kavya G. An Insight into the Recent Synthetic Approaches of Benzimidazoles 2021
4 Anusha S. Das Recent Developments in the Synthesis of Fluorene-Based Compounds 2021
5 A. Chithra Mohan Fluorene-Based Multifaceted Molecules with Diverse Applications 2021
6 Aiswarya Manoj Synthesis, Characterization, and Photophysical Studies of Fluorene-Based Imines and Phenylhydrazones 2023
7 Heera R. Push-Pull Chalcone Derivatives; Synthesis and Investigation on their Absorption and Emission Characteristics 2023
8 Swathi V. The Effect of Nitro (-NO2) Group on the Absorption and Emission Properties of E-Chalcones 2023
Experience
Employer Position Period
Dept. of Chemistry, Amrita School of Physical Sciences, Amritapuri Campus, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India Assistant Professor (Sr. Gr.) July 2022 till date
Dept. of Chemistry, Amrita School of Physical Sciences, Amritapuri Campus, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India Assistant Professor July 2018 to June 2022
Dept. of Chemistry, T. K. M. M. College, Nangiarkulangara, Kerala, India Assistant Professor on Contract July 2017 to March 2018
Dept. of Chemistry, T. K. M. M. College, Nangiarkulangara, Kerala, India Assistant Professor on Contract August 2016 to March 2017
Dept. of Chemistry, St. Michael’s College, Cherthala, Kerala, India Assistant Professor on Contract July 2015 to March 2016
Dept. of Chemistry, Amrita School of Arts and Sciences, Amritapuri Campus, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India Teaching Assistant August 2012 to February 2013
Dept. of Chemistry, Amrita School of Arts and Sciences, Amritapuri Campus, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India Junior Project Fellow August 2009 to July 2012
Research Experiences
  • Junior Project Fellow, Dept. of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri Project Title: “Macrocyclic and carbocyclic constructions mediated by SET oxidations of styrenes, allenes and cyclopropanes”, sponsored by Department of Science and Technology (DST), Govt. of India, New Delhi.
    Duration:August 2009 to July 2012 (3 years)
    Highlights:

    • Synthesis of macrocyclic crown ethers containing fluorene molecules by single electron oxidation.
    • Study of the effect of the length of the styrene tether on the properties of the macrocyclic crown ether.
    • Synthesis of benzannulated heterocycles by the intramolecular cyclization of suitable precursors.
    • Study of the single electron oxidation behavior of acetylenes and allenes and additions of these to 1,3-dicarbonyl systems.
    • Synthesis of vicinal tricarbonyl compounds by the single electron oxidation of 1,3-dicarbonyl systems.
    • Comparative study of the single electron oxidation potential of Fe (III) and Ag (I) salts.
  • Research Scholar, Dept. of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri
    Thesis Title: “New Synthetic Methods for Multi-Substituted Furans, Vicinal Triketones and Benzylidene Fluorene Derivatives Using Cerium(IV) Ammonium Nitrate”
    Highlights:

    • Developed a new method for the preparation of tetrasubstituted and fused furans by the oxidative addition of terminal acetylenes to 1,3-dicarbonyl compounds in the presence of CAN.
    • A mild protocol for the synthesis of VTCs from β-dicarbonyl compounds has been achieved by using catalytic amounts of CAN.
    • A mild and improved method for the synthesis of spirodihydrofuran fluorenes and dinitrato adducts of benzylidene and diphenyl methylidenefluorene has been discovered using solid phase CAN reaction.
    • Carried out the dinitration of benzylidene and diphenyl methylidenefluorene using CAN supported on silica.
Professional Experiences
  • Assistant Professor, Dept. of Chemistry, Amrita School of Physical Sciences, Amritapuri Campus, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India. (July 2018 to Present, 4years, 1 month)
  • Assistant Professor on Contract, Dept. of Chemistry, T. K. M. M. College, Nangiarkulangara, Kerala, India. (August 2016 to March2017and July 2017 to March2018, 17 months)
  • Assistant Professor on Contract, Dept. of Chemistry, St. Michael’s College, Cherthala, Kerala, India. (July 2015 to March 2016, 9 months)
  • Teaching Assistant, Dept. of Chemistry, Amrita School of Arts and Sciences, Amritapuri Campus, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India. (August 2012 to February 2013, 7 months)
Research Activities
  • Current research group comprises of 3 PhD, 7Postgraduate and 3Undergraduate students.
  • Successfully completed5 M. Sc.Projects and 9 MiniProjects.
  • Co-guided 4 M. Phil. students and 8 M. Sc. students towards the successful completion of their projects.
  • Submitted a project proposal to the Department of Science & Technology, Government of Indiaas a co-investigator for India-Russia Joint Research Call 2021
Achievements & Awards
  • Recipient of AIRA Award 2024 in the Journal Publication Category from Amrita Vishwa Vidyapeetham.
  • Selected as a Community Member of the American Chemical Society (ACS).
  • Reviewer for an international journal, Polycyclic Aromatic Compounds.
  • Reviewer for Elsevier journals.
  • A journal paper published in Tetrahedron Letters got more than 5000 downloads from Science Direct.
  • Received “Certificate of Appreciation” from Amrita Vishwa Vidyapeetham University in 2014 for getting international research publication.
  • Received “Certificate of Appreciation” from Amrita Vishwa Vidyapeetham University in 2012 for getting international research publication.
  • 3rd rank holder in B. Sc. Industrial Chemistry, University of Kerala.
Research Collaborators
Sl# Name Designation and Institution Details
1 Dr. Y. C. Sunilkumar Associate Professor, Dayananda Sagar University, Bengaluru
2 Dr. E. G. Jayasree Professor, CUSAT, Cochin, Kerala
3 Dr. Sujith Sudheendran Swayamprabha Principal Engineer, Bruckewell Technology Corp., Taiwan
4 Dr. Jayakrishnan Aerathupalathu Janardhanan Research associate, Institute of Chemistry, Academia Sinica, Taiwan
5 Dr. Manoj Parameswaran Assistant Professor, Department of Chemistry, St. Michael’s College, Cherthala
6 Dr. Ani Deepthi Assistant Professor, University of Kerala
7 Dr. Sreekanth Ramachandran Director, Medicinal Chemistry, Enveda Biosciences, Hyderabad
8 Dr. Chinchu Bose Assistant Professor, Amrita School of Biotechnology, Amritapuri
Courses Handled

During last 3 years

Doctoral and Pre-doctoral Levels

  • 19CHE702 Advanced Scientific Techniques in Chemical Analysis (5 credits)
  • 19CHE798 Seminar, Fieldwork and Review writing (5 credits)
  • 19CHE731 Retro Synthetic analysis (4 credits)
  • CH705 Heterocyclic Chemistry (4 credits)
  • SS801 Advanced Organic Chemistry (4 credits)

Postgraduate Levels

  • 18CHY637 Medicinal Chemistry (3 credits)
  • 18CHY514 Heterocyclic and Natural Products Chemistry (3 credits)
  • 18CHY583 Advanced Physical Chemistry Lab (2 credits)
  • 18CHY681 Organic Qualitative Analysis Lab (2 credits)
  • 18CHY682 Instrumental and Analytical Methods Lab (2 credits)

Undergraduate Levels

  • 18CHY313 Organic Chemistry III (4 credits)
  • 18CHY303 Organic Chemistry II (4 credits)
  • 18CHY335 Introduction to Food Chemistry (3 credits)
  • CHY103 Chemistry (4 credits)
  • 21CHY105 Engineering Chemistry C (3 credits)
  • 19CHY101 Engineering Chemistry A (3 credits)
  • 15CHY100 Chemistry (3 credits)
  • 15ENV300 Environmental Science and Sustainability (3 credits)
  • 18CHY282 Basic Organic Qualitative Lab (1 credit)
  • 15CHY381 Basic Physical Chemistry Lab (1 credit)
  • 18CHY384 Organic Synthesis and Estimation Lab (1 credit)
  • 19CHY181 Engineering Chemistry Lab 1 (1 credit)
  • 19CHY182 Engineering Chemistry Lab 2 (1 credit)
Administrative Roles

University Level

  • Deputy Controller of Admissions – School of Physical Sciences

Campus Level

  • Student activity center coordinator
  • Multi-fest coordinator
  • Cultural event coordinator
  • Criteria-wise NAAC audit coordinator
  • Convocation committee member
  • Discipline committee member
  • Induction program coordinator

Department Level

  • 18CHY313 Organic Chemistry III (4 credits)
  • 18CHY303 Organic Chemistry II (4 credits)
  • 18CHY335 Introduction to Food Chemistry (3 credits)
  • CHY103 Chemistry (4 credits)
  • 21CHY105 Engineering Chemistry C (3 credits)
  • 19CHY101 Engineering Chemistry A (3 credits)
  • 15CHY100 Chemistry (3 credits)
  • 15ENV300 Environmental Science and Sustainability (3 credits)
  • 18CHY282 Basic Organic Qualitative Lab (1 credit)
  • 15CHY381 Basic Physical Chemistry Lab (1 credit)
  • 18CHY384 Organic Synthesis and Estimation Lab (1 credit)
  • 19CHY181 Engineering Chemistry Lab 1 (1 credit)
  • 19CHY182 Engineering Chemistry Lab 2 (1 credit)
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