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Dr. Jyotsna Nambiar

Assistant Professor (Sr. Grd.), School of Biotechnology, Amritapuri

Qualification: BSc, MSc, Ph.D
jyotsnanambiar@am.amrita.edu
Ph: +919567656948
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Research Interest: Cancer Biology, Natural product Lead Discovery

Bio Publications Alma Mater Awards/Honor Research Projects Teaching
Bio

Dr. Jyotsna Nambiar currently serves as an Assistant Professor (Sr. Grd.) at the School of Biotechnology, Amritapuri campus. She completed her Ph.D. in Biotechnology from the Amrita Vishwa Vidyapeetham in the year 2016. During her Ph.D., she was involved in understanding the regulation of Matrix metalloproteinases in cancer cells by several natural product extracts. The studies resulted in the first demonstration of anacardic acid, a compound purified from cashew nut shell liquid commonly used in traditional medicine to be very effective in blocking the activity of matrix metalloproteinases (MMPs) specifically gelatinases, proteins that are implicated in several different forms of cancer. The work also involved understanding various signalling pathways including the Epidermal Growth Factor pathway that are deregulated in cancers and the direct link with MMPs. Further studies involves generating 3D spheroid models and understanding how these potential compounds affected the formation of spheroids. Further work involves understanding the role of bacterial infections in promoting cancer progression. Other projects include understanding the dysregulation of osteoblasts and osteoclasts under inflammatory conditions to delineate their role in bone diseases.

Publications

Journal Article

Year : 2021

Unifloral ajwain honey ameliorates differential inhibition of matrix metalloproteinases 2 and 9 protein, cytotoxicity, and antioxidant potential

Cite this Research Publication : Kulkarni, Shruti & Mishra, Sanjay & Patil, Sadanand & Nambiar, Jyotsna & Math, Avinash. (2021). Unifloral ajwain honey ameliorates differential inhibition of matrix metalloproteinases 2 and 9 protein, cytotoxicity, and antioxidant potential. Journal of Ayurveda and Integrative Medicine. 12. 10.1016/j.jaim.2021.05.012.

Publisher : Journal of Ayurveda and Integrative Medicine

Year : 2021

Anacardic acid-mediated regulation of osteoblast differentiation involves mitigation of inflammasome activation pathways

Cite this Research Publication : Dr. Bipin G. Nair, M, V., and J, N., “Anacardic acid-mediated regulation of osteoblast differentiation involves mitigation of inflammasome activation pathways”, Molecular and Cellular Biochemistry, vol. 476(2):1-11, 2021.

Publisher : Springer

Year : 2020

RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata

Cite this Research Publication : Drishya G., Dr. Jyotsna Nambiar, Sanu K. Shaji, Muralidharan Vanuopadath, Achuthan A., Kumar Abishek, Alias Ashna, Ayesha Sherif, Catherine Joseph, Divya P., Damu Sunilkumar, Chinchu Bose, Dr. Sobha V. Nair, S. Sudarslal, Dr. Geetha Kumar, Lakshmi S., and Dr. Bipin G. Nair, “RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata”, Journal of Biosciences, vol. 45, no. 1, pp. 1-11, 2020.

Publisher : Journal of Biosciences

Year : 2018

(I-3,II-3)-Biacacetin-mediated Cell Death involves Mitochondria

Cite this Research Publication : Jyotsna Nambiar, Gayathri Vijayakumar, G. Drishya, Sanu K Shaji, Nanjan Pandurangan, Geetha B. Kumar, and Dr. Bipin G. Nair, “(I-3,II-3)-Biacacetin-mediated cell death involves mitochondria.”, Molecular and cellular biochemistry, 2018

Publisher : Molecular and cellular biochemistry

Year : 2016

Anacardic Acid Inhibits Gelatinases through the Regulation of Spry2, MMP-14, EMMPRIN and RECK

Cite this Research Publication : Dr. Jyotsna Nambiar, Chinchu Bose, Meera Venugopal, Dr. Asoke Banerji, T. B. Patel, Dr. Geetha Kumar, and Dr. Bipin G. Nair, “Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK”, Experimental Cell Research, vol. 349, pp. 139-151, 2016

Publisher : Experimental Cell Research

Year : 2016

Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK.

Cite this Research Publication : J. Nambiar, Bose, C., Venugopal, M., Banerji, A., Patel, T. B., Dr. Geetha Kumar, and Nair, B. G., “Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK.”, Experimental Cell Research, vol. 349, no. 1, pp. 139-151, 2016.

Publisher : Experimental Cell Research.

Year : 2015

Synthesis and Discovery of (I-3,II-3)-Biacacetin as a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9

Cite this Research Publication : Pandurangan Nanjan, Dr. Jyotsna Nambiar, Dr. Bipin G. Nair, and Dr. Asoke Banerji, “Synthesis and Discovery of (I-3,II-3)-Biacacetin as a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9”, Bioorganic & Medicinal Chemistry, vol. 23, pp. 3781 - 3787, 2015

Publisher : Bioorganic Medicinal Chemistry

Year : 2015

A Novel2-Alkoxy-3, 5-Dihydroxypyridine Mediated Regulation of Gelatinases

Cite this Research Publication : Dr. Jyotsna Nambiar, Dr. Geetha Kumar, Sanjana S. R., Gorantla S. N., Lankalapalli R. S., and Dr. Bipin G. Nair, “A Novel2-Alkoxy-3, 5-Dihydroxypyridine Mediated Regulation of Gelatinases”, International Journal of Pharma and Bio Sciences, vol. 6, pp. 779-788, 2015.

Publisher : International Journal of Pharma and Bio Sciences

Year : 2012

Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9

Cite this Research Publication : A. Omanakuttan, Dr. Jyotsna Nambiar, Rodney M. Harris, Chinchu Bose, Pandurangan Nanjan, Rebu K. Varghese, Geetha B. Kumar, John A. Tainer, Dr. Asoke Banerji, J. Jefferson P. Perry, and Dr. Bipin G. Nair, “Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9”, Molecular Pharmacology, vol. 82, no. 4, pp. 614-622, 2012

Publisher : Molecular Pharmacology

Conference Paper

Year : 2015

Regulation of Gelatinases by (I-3,II-3)-Biacacetin, a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9

Cite this Research Publication : Dr. Jyotsna Nambiar, Geetha B. Kumar, Pandurangan Nanjan, Dr. Asoke Banerji, and Dr. Bipin G. Nair, “Regulation of Gelatinases by (I-3,II-3)-Biacacetin, a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9”, in The XXXIX All India Cell Biology Conference, 2015.

Publisher : The XXXIX All India Cell Biology Conference

Year : 2015

In Vitro Culture of Primary Cells from Cancer Patients- Screening for Potent MMP-9 Inhibitors

Cite this Research Publication : Drishya G., Lavanya Ashokan, Dr. Jyotsna Nambiar, Sanu K Shaji, Lakshmi S, Geetha B. Kumar, and Dr. Bipin G. Nair, “In Vitro Culture of Primary Cells from Cancer Patients- Screening for Potent MMP-9 Inhibitors”, in The XXXIX All India Cell Biology Conference , 2015

Publisher : The XXXIX All India Cell Biology Conference

Year : 2013

Anacardic Acid regulates Gelatinases by modulation of MT1-MMP, TIMP-2 and EGF receptor signaling in Fibrosarcoma cells

Cite this Research Publication : Dr. Jyotsna Nambiar, Geetha B. Kumar, and Nair, B. G., “Anacardic Acid regulates Gelatinases by modulation of MT1-MMP, TIMP-2 and EGF receptor signaling in Fibrosarcoma cells”, in Amrita Bioquest, 2013.

Publisher : Amrita Bioquest

Alma Mater
  • Ph.D. Biotechnology (2016)
  • MSc. Biotechnology, Amrita Vishwa Vidyapeetham (2009)
  • B.Tech. Biotechnology, Jawaharlal Nehru Technological University, Hyderabad (2007)

Awards/Honor
1. “Regulation of Osteoclastogenesis by Anacardic Acid: Role in
Osteoarthritis” at OACON 2019, 3rd International Conference on Osteoarthritis.
2. Certificate of appreciation, Amrita Vishwa Vidyapeetham, Academic achievements
(2013-2014).
3.UGC-NET Lectureship and JRF, University Grants Commission, Government
of India, Qualified for lectureship and Junior Research Fellowship in Life Sciences
through National Eligibility Test
Research Projects
  • Anacardic Acid – A novel template for cancer therapy
  • Elucidating the molecular mechanisms of Anacardic Acid mediated regulation of Matrix Metalloproteinases in Cancer
Teaching
Cell Biology , Cell signaling, Cell Biology and Stem Cell Biology, Pharmacology, Introductory Biology
Laboratory Courses- Cell and Molecular Biology, Immunology, Recombinant DNA technology.
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