Publication

Abstract : pGanciclovir is an antiviral medication used to treat cytomegalovirus (CMV) infection. The chance of getting pancreatitis with ganciclovir is lt;1%. Upto 2% of acute pancreatitis may be caused by drugs. In view of CMV virenia he was started on Gancyclovir twice a day initially then counts was found to reduced. Hence the dose reduced to once daily dosing till CMV become negative. But he presented with severe abdominal pain. Emergency USG abdomen showed hepatomegaly with moderate infiltration of liver. His serum amylase and lipase levels were high, indicative of acute pancreatitis. So he was treated conservatively with supportive medications. Patient recovered with conservative measures and was then asymptomatic, tolerating oral feeds well, there were no significant abdominal pain. CT did not show any features of chronic pancreatitis. No further significant pain indicative of pancreatitis. To assess the probability an event which was caused by the therapeutic modality or ingested drug, the Naranjo Scale has been used. It was found that the severity of the ganciclovir induced pancreatitis is a probable ADR. Supportive care and withdrawal of the offending agent and are the management options for drug-induced acute pancreatitis./p