Publication

Abstract : The drug is obtained from the dried whole plants of Premna corymbosa of family Verbenaceae. It is also calledMunna, Arni, Agnimanthah etc. Literature survey revealed that the hydroalcoholic extract of roots of Premna corymbosa Rottlpossess anti hyperglycemic, anti-inflammatory, antihyperlipidemic and antibacterial activity. The major chemical constituentsobtained from it is flavanoids, alkaloids etc. The root is regarded as an alternative tonic and useful in the diseases of nervoussystem. To confirm the veracity of aforementioned claim, we have evaluated the anticonvulsant effect of the extract. In thisinvestigation, the mice were pretreated with different doses of Premna corymbosa extract (200, 400mg/kg) for 10 days andthen, they were subjected to Pentylenetetrazole (80 mg/kg) and maximal electroshock seizures (50mA, 0.2s) treatment. Themethanolic extract of Premna corymbosa at the dose of 200 and 400 mg/kg significantly delayed the latency to the onset offirst clonus of Pentylenetetrazole treated mice respectively. Whereas in case of maximal electroshock-seizures, the dose of 200and 400 mg/kg significantly reduced the duration of hind limb extension and both the doses were statistically found to beequipotent. The reference standards, diazepam (2 mg/kg) and Phenytoin (25 mg/kg) provided complete protection. Thus,present study revealed anticonvulsant effect of Premna corymbosa against Pentylenetetrazole and maximal electroshockinduced convulsions in mice.