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Electrospun Drug-eluting Sutures for Local Anesthesia

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Controlled Release

Source : Journal of Controlled Release, Volume 161, Number 3, p.903 - 909 (2012)

Url : http://www.sciencedirect.com/science/article/pii/S0168365912004014

Keywords : Bupivacaine, Local anesthetic, Poly(lactic-co-glycolic acid), Prolonged release, suture

Campus : Kochi

School : Center for Nanosciences

Center : Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2012

Abstract : We have developed a local anesthetic-eluting suture system which would combine the function and ubiquity of the suture for surgical repair with the controlled release properties of a biodegradable polymeric matrix. Drug-free and drug-loaded poly(lactic-co-glycolic acid) (PLGA) sutures were fabricated by electrospinning, with or without the local anesthetic bupivacaine. The tensile strength of the electrospun sutures decreased as drug content increased, but strains remained relatively similar across all groups. Sutures released their entire drug payload over the course of 12days and maintained approximately 12% of their initial tensile strength after 14days of incubation in vitro. In a rat skin wound model, local analgesia was achieved 1day after surgery and lasted approximately 1week in 90% of treated animals (n=10, plt;0.05), and all wounds were able to heal normally without the need for further reinforcement. The sutures caused tissue reaction in vivo that was comparable to that seen with a commercially available suture composed of PLGA. Such sutures may enhance perioperative analgesia and mitigate the need for standard postoperative opioid analgesics.

Cite this Research Publication : C. B. Weldon, Tsui, J. H., Dr. Sahadev Shankarappa, Nguyen, V. T., Ma, M., Anderson, D. G., and Kohane, D. S., “Electrospun Drug-eluting Sutures for Local Anesthesia”, Journal of Controlled Release, vol. 161, pp. 903 - 909, 2012.

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