Publication

Abstract : Background Leukemias are characterized by an idiopathic proliferation of a progenitor cell that is committed to a single cell lineage. The diagnosis of acute leukemias (AL) relies both on clinical features and an array of multidisciplinary approaches including morphology, immunophenotyping, cytogenetic and molecular investigations. About 25% of adult and 2-4% of childhood leukemias show positivity for Ph+. But there are no unique morphological or cytochemical features that distinguish these types from all other types of ALL. Material and Method Three cases diagnosed as acute leukemia showing BCR-ABL1 association were studied for clinical presentation. Heamatological parameters, bone marrow examination and fl owcytometery for immunophenotyping was carried out. Three cases of ALL with BCR-ABL1 association differentiation are being described here. Results Out of the three cases cases studied two were adult onset ALL with BCR-ABL1 association and one case which was diagnosed morphologically on peripheral smear & bone marrow as AML and Immunophenotyping done by fl ow cytometry showed expression of both myeloid and lymphoid cell markers with a score of >2 in each of the lineages and was also Ph+.Conclusion ALL with BCR-ABL1 association has the worst prognosis among patients with ALL. Treatment with imitanab in addition to high dose chemotherapy has been reported to improve early event free survival.